UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM 8-K

                                 CURRENT REPORT
                       Pursuant to Section 13 or 15(d) of
                       the Securities Exchange Act of 1934

                                  May 21, 2007
                Date of Report (Date of earliest event reported)

                                 ANTIGENICS INC.
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             (Exact name of registrant as specified in its charter)



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           DELAWARE                   000-29089                06-1562417
 (State or other jurisdiction        (Commission             (IRS Employer
       of incorporation)             File Number)          Identification No.)

           162 Fifth Avenue, Suite 900
                   New York, NY                                    10010
     (Address of principal executive offices)                    (Zip Code)

                                  212-994-8200
              (Registrant's telephone number, including area code)

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Check the appropriate box below if the Form 8-K filing is intended to
simultaneously satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):

[] Written communications pursuant to Rule 425 under the Securities Act
    (17 CFR 230.425)

[] Soliciting material pursuant to Rule 14a-12 under the Exchange Act
    (17 CFR 240.14a-12)

[] Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange
   Act (17 CFR 240.14d-2(b))

[] Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange
   Act (17 CFR 240.13e-4(c))



Item 7.01   Regulation FD Disclosure

                  On May 21, 2007, Antigenics Inc. announced additional
                  follow-up data on the company's Oncophage(R) (vitespen), a
                  Phase 3 investigational therapeutic cancer vaccine. The
                  end-of-study results, which reflect an additional 17 months'
                  data collection, showed that in a substantial subset of
                  patients (n = 362) at intermediate risk for disease
                  recurrence, Oncophage demonstrated a clinically significant
                  improvement in recurrence-free survival (RFS) of approximately
                  45 percent (P < 0.01; hazard ratio [HR] = 0.55). The full text
                  of the press release issued in connection with the
                  announcement is being furnished as Exhibit 99.1 to this
                  current report on Form 8-K.



Item 9.01         Financial Statements and Exhibits


         (d) Exhibits


         The following exhibit is furnished herewith:

                      99.1 Press Release dated May 21, 2007



                                   SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the
Registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.

                                            ANTIGENICS INC.

Date: May 21, 2007
                                            By:       /s/ Garo H. Armen
                                                --------------------------------
                                            Garo H. Armen, Ph.D.
                                            Chairman and Chief Executive Officer




EXHIBIT INDEX


Exhibit No.       Description of Exhibit
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99.1              Press Release dated May 21, 2007