UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  SCHEDULE 13G
                    UNDER THE SECURITIES EXCHANGE ACT OF 1934

                             ZIOPHARM ONCOLOGY, INC.
                                (Name of Issuer)

                    COMMON STOCK, PAR VALUE $0.001 PER SHARE
                         (Title of Class of Securities)

                                    98973P101
                                 (CUSIP NUMBER)

                                   MAY 3, 2006
             (Date of event which requires filing of this statement)

      Check the appropriate box to designate the rule pursuant to which this
Schedule is filed:

|_|   Rule 13d-1(b)

|X|   Rule 13d-1(c)

|_|   Rule 13d-1(d)

* The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
notes).

                               Page 1 of 11 Pages



CUSIP No. 98973P101                    13G                    Page 2 of 11 Pages

--------------------------------------------------------------------------------
1.   NAME OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

     Millennium Partners, L.P.
     13-3521699
--------------------------------------------------------------------------------
2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

                                                                 (a)  |_|
                                                                 (b)  |X|
--------------------------------------------------------------------------------
3.   SEC USE ONLY


--------------------------------------------------------------------------------
4.   CITIZENSHIP OR PLACE OF ORGANIZATION

     Cayman Islands
--------------------------------------------------------------------------------
  NUMBER OF    5.   SOLE VOTING POWER

   SHARES           -0-
               -----------------------------------------------------------------
BENEFICIALLY   6.   SHARED VOTING POWER

  OWNED BY          793,486
               -----------------------------------------------------------------
    EACH       7.   SOLE DISPOSITIVE POWER

  REPORTING         -0-
               -----------------------------------------------------------------
   PERSON      8.   SHARED DISPOSITIVE POWER

    WITH            793,486
--------------------------------------------------------------------------------
9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     793,486
--------------------------------------------------------------------------------
10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

                                                                          |_|
--------------------------------------------------------------------------------
11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

     5.2%
--------------------------------------------------------------------------------
12.  TYPE OF REPORTING PERSON*

     PN
--------------------------------------------------------------------------------
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!



CUSIP No. 98973P101                    13G                    Page 3 of 11 Pages

--------------------------------------------------------------------------------
1.   NAME OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

     Millenco, L.P.
     13-3532932
--------------------------------------------------------------------------------
2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

                                                                 (a)  |_|
                                                                 (b)  |X|
--------------------------------------------------------------------------------
3.   SEC USE ONLY


--------------------------------------------------------------------------------
4.   CITIZENSHIP OR PLACE OF ORGANIZATION

     Delaware
--------------------------------------------------------------------------------
  NUMBER OF    5.   SOLE VOTING POWER

   SHARES           -0-
               -----------------------------------------------------------------
BENEFICIALLY   6.   SHARED VOTING POWER

  OWNED BY          -0-
               -----------------------------------------------------------------
    EACH       7.   SOLE DISPOSITIVE POWER

  REPORTING         -0-
               -----------------------------------------------------------------
   PERSON      8.   SHARED DISPOSITIVE POWER

    WITH            -0-
--------------------------------------------------------------------------------
9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     793,486
--------------------------------------------------------------------------------
10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

                                                                          |_|
--------------------------------------------------------------------------------
11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

     5.2%
--------------------------------------------------------------------------------
12.  TYPE OF REPORTING PERSON*

     PN, BD
--------------------------------------------------------------------------------
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!



CUSIP No. 98973P101                    13G                    Page 4 of 11 Pages

--------------------------------------------------------------------------------
1.   NAME OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

     Millennium Management, L.L.C.
     13-3804139
--------------------------------------------------------------------------------
2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

                                                                 (a)  |_|
                                                                 (b)  |X|
--------------------------------------------------------------------------------
3.   SEC USE ONLY


--------------------------------------------------------------------------------
4.   CITIZENSHIP OR PLACE OF ORGANIZATION

     Delaware
--------------------------------------------------------------------------------
  NUMBER OF    5.   SOLE VOTING POWER

   SHARES           -0-
               -----------------------------------------------------------------
BENEFICIALLY   6.   SHARED VOTING POWER

  OWNED BY          793,486
               -----------------------------------------------------------------
    EACH       7.   SOLE DISPOSITIVE POWER

  REPORTING         -0-
               -----------------------------------------------------------------
   PERSON      8.   SHARED DISPOSITIVE POWER

    WITH            793,486
--------------------------------------------------------------------------------
9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     793,486
--------------------------------------------------------------------------------
10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

                                                                          |_|
--------------------------------------------------------------------------------
11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

     5.2%
--------------------------------------------------------------------------------
12.  TYPE OF REPORTING PERSON*

     OO
--------------------------------------------------------------------------------
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!



CUSIP No. 98973P101                    13G                    Page 5 of 11 Pages

--------------------------------------------------------------------------------
1.   NAME OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

     Israel A. Englander
--------------------------------------------------------------------------------
2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

                                                                 (a)  |_|
                                                                 (b)  |X|
--------------------------------------------------------------------------------
3.   SEC USE ONLY


--------------------------------------------------------------------------------
4.   CITIZENSHIP OR PLACE OF ORGANIZATION

     United States
--------------------------------------------------------------------------------
  NUMBER OF    5.   SOLE VOTING POWER

   SHARES           -0-
               -----------------------------------------------------------------
BENEFICIALLY   6.   SHARED VOTING POWER

  OWNED BY          793,486
               -----------------------------------------------------------------
    EACH       7.   SOLE DISPOSITIVE POWER

  REPORTING         -0-
               -----------------------------------------------------------------
   PERSON      8.   SHARED DISPOSITIVE POWER

    WITH            793,486
--------------------------------------------------------------------------------
9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     793,486
--------------------------------------------------------------------------------
10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

                                                                          |_|
--------------------------------------------------------------------------------
11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

     5.2%
--------------------------------------------------------------------------------
12.  TYPE OF REPORTING PERSON*

     IN
--------------------------------------------------------------------------------
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!



CUSIP No. 98973P101                    13G                    Page 6 of 11 Pages

Item 1.

(a)   Name of Issuer

      ZIOPHARM Oncology, Inc., a company incorporated under the laws of Delaware
      (the "Company").

(b)   Address of Issuer's Principal Executive Offices:

      1180 Avenue of the Americas, 19th Floor
      New York, NY 10036

Item 2(a). Name of Person Filing

Item 2(b). Address of Principal Business Office

Item 2(c). Citizenship

         Millennium Partners, L.P.
         c/o Millennium Management, L.L.C.
         666 Fifth Avenue
         New York, New York 10103
         Citizenship: Cayman Islands

         Millenco, L.P.
         c/o Millennium Management, L.L.C.
         666 Fifth Avenue
         New York, New York 10103
         Citizenship: Delaware

         Millennium Management, L.L.C.
         666 Fifth Avenue
         New York, New York 10103
         Citizenship: Delaware

         Israel A. Englander
         c/o Millennium Management, L.L.C.
         666 Fifth Avenue
         New York, New York 10103
         Citizenship: United States

(d)   Title of Class of Securities

      Common Stock, par value $0.001 per share ("Common Stock")

(e)   CUSIP Number

      98973P101

Item 3. If this statement is filed pursuant to Rule 13d-1(b), or 13d-2(b), check
whether the person filing is a:

(a)   |_|   Broker or dealer registered under Section 15 of the Act (15 U.S.C.
            78o).

(b)   |_|   Bank as defined in Section 3(a)(6) of the Act (15 U.S.C. 78c).

(c)   |_|   Insurance company as defined in Section 3(a)(19) of the Act (15
            U.S.C. 78c).

(d)   |_|   Investment company registered under Section 8 of the Investment



CUSIP No. 98973P101                    13G                    Page 7 of 11 Pages

            Company Act of 1940 (15 U.S.C. 80a-8).

(e)   |_|   An investment adviser in accordance with Rule 13d-1(b)(1)(ii)(E);

(f)   |_|   An employee benefit plan or endowment fund in accordance with Rule
            13d-1(b)(1)(ii)(F);

(g)   |_|   A parent holding company or control person in accordance with Rule
            13d-1(b)(1)(ii)(G);

(h)   |_|   A savings association as defined in Section 3(b) of the Federal
            Deposit Insurance Act (12 U.S.C. 1813);

(i)   |_|   A church plan that is excluded from the definition of an investment
            company under Section 3(c)(14) of the Investment Company Act of 1940
            (15 U.S.C. 80a-3);

(j)   |_|   Group, in accordance with Rule 13d-1(b)(1)(ii)(J).

If this statement is filed pursuant to Rule 13d-1(c), check this box. [X]

Item 4. Ownership

      Provide the following information regarding the aggregate number and
percentage of the class of securities of the issuer identified in Item 1.

(a)   Amount Beneficially Owned

      Each Reporting Person may be deemed the beneficial owner of:

            (i)   231,931 shares of Common Stock that were acquired by
                  Millennium Partners, L.P., a Cayman Islands exempted limited
                  partnership ("Millennium Partners")on or about December 13,
                  2005, in exchange for 462,962 shares of Series A Convertible
                  Preferred Stock, $0.001 par value per share, of Ziopharm, Inc.
                  (the "Preferred Shares"). The Preferred Shares had been
                  acquired on April 12, 2005 pursuant to a Subscription
                  Agreement between Ziopharm, Inc. and Millennium Partners. The
                  Preferred Shares were exchanged for shares of Common Stock in
                  connection with Ziopharm, Inc.'s merger with EasyWeb, Inc.;

            (ii)  431,965 shares of Common Stock that were issued to Millennium
                  Partners on May 3, 2006 in connection with a Subscription
                  Agreement between the Company and Millennium Partners; and

            (iii) 129,590 shares of Common Stock issuable to Millennium Partners
                  upon exercise of a Common Stock Purchase Warrant dated May 3,
                  2006.

      The managing partner of Millennium Partners and the general partner of
Millenco, L.P. ("Millenco") is Millennium Management, L.L.C., a Delaware limited
liability company ("Millennium Management"), and consequently Millennium
Management may be deemed to have voting control and investment discretion over
securities owned by Millennium Partners and by Millenco. Israel A. Englander
("Mr. Englander") is the managing member of Millennium Management. As a result,
Mr. Englander may be deemed to be the beneficial owner of any shares deemed to
be beneficially owned by Millennium Management. The foregoing should not be
construed in and of itself as an admission by either of Millennium Management or



CUSIP No. 98973P101                    13G                    Page 8 of 11 Pages

Mr. Englander as to beneficial ownership of the shares owned by Millennium
Partners or Millenco.

      Note: Millennium Partners is a limited partner of Millenco. As a limited
partner, Millennium Partners has no investment or voting control over Millenco
or its securities position.

(b)   Percent of Class

      As of the close of trading on the date of this filing, each Reporting
Person may be deemed the beneficial owner of 793,486 shares of Common Stock, or
5.2% of the Company's issued and outstanding shares of Common Stock (which
percentage was calculated based on a figure of 15,264,248 outstanding shares of
Common Stock as of May 3, 2006, as reported on the Company's Current Report on
Form 8-K dated May 3, 2006 and filed with the Securities and Exchange Commission
on May 3, 2006).

(c)   Number of shares as to which such person has:

            (i)   Sole power to vote or to direct the vote:

                  -0-

            (ii)  Shared power to vote or to direct the vote

                  793,486

            (iii) Sole power to dispose or to direct the disposition of

                  -0-

            (iv)  Shared power to dispose or to direct the disposition of

                  793,486

Item 5. Ownership of Five Percent or Less of a Class

      If this statement is being filed to report the fact that as of the date
hereof the reporting person has ceased to be the beneficial owner of more than
five percent of the class of securities, check the following | |.

Item 6. Ownership of More than Five Percent on Behalf of Another Person.

      Not applicable.

Item 7. Identification and Classification of the Subsidiary Which Acquired the
Security Being Reported on By the Parent Holding Company

      Not applicable.

Item 8. Identification and Classification of Members of the Group

      See Exhibit I.

Item 9. Notice of Dissolution of Group

      Not applicable.



CUSIP No. 98973P101                    13G                    Page 9 of 11 Pages

Item 10. Certification

By signing below each of the undersigned certifies that, to the best of its
knowledge and belief, the securities referred to above were not acquired and are
not held for the purpose of or with the effect of changing or influencing the
control of the issuer of the securities and were not acquired and are not held
in connection with or as a participant in any transaction having that purpose or
effect.

Exhibits:

Exhibit I: Joint Filing Agreement, dated as of May 9, 2006, by and among
Millennium Partners, L.P., Millenco, L.P., Millennium Management, L.L.C. and
Israel A. Englander.



CUSIP No. 98973P101                    13G                   Page 10 of 11 Pages

                                    SIGNATURE

After reasonable inquiry and to the best of its knowledge and belief, each of
the undersigned certifies that the information with respect to it set forth in
this statement is true, complete, and correct.

Dated: May 9, 2006


MILLENNIUM PARTNERS, L.P.                   MILLENCO, L.P.


By: Millennium Management, L.L.C.           By: Millennium Management, L.L.C.
    its general partner                         its general partner


By:  /s/ Terry Feeney                       By:  /s/ Terry Feeney
   ----------------------------------          ---------------------------------
   Name:  Terry Feeney                         Name:  Terry Feeney
   Title: Chief Operating Officer              Title: Chief Operating Officer


                                            MILLENNIUM MANAGEMENT, L.L.C.
    /s/ Israel A. Englander by Simon
Lorne pursuant to Power of Attorney
filed with SEC on June 6, 2005              By:  /s/ Terry Feeney
-------------------------------------          ---------------------------------
ISRAEL A. ENGLANDER                            Name:  Terry Feeney
                                               Title: Chief Operating Officer



CUSIP No. 98973P101                    13G                   Page 11 of 11 Pages

                                    EXHIBIT I

                             JOINT FILING AGREEMENT

This will confirm the agreement by and among the undersigned that the Schedule
13G filed with the Securities and Exchange Commission on or about the date
hereof with respect to the beneficial ownership by the undersigned of the Common
Stock, par value $0.001 per share, of ZIOPHARM Oncology, Inc., a company
incorporated under the laws of Delaware, is being filed, and all amendments
thereto will be filed, on behalf of each of the persons and entities named below
in accordance with Rule 13d-1(k) under the Securities Exchange Act of 1934, as
amended. This Agreement may be executed in two or more counterparts, each of
which shall be deemed an original, but all of which together shall constitute
one and the same instrument.

Dated: May 9, 2006

MILLENNIUM PARTNERS, L.P.                   MILLENCO, L.P.

By: Millennium Management, L.L.C.           By: Millennium Management, L.L.C.
    its general partner                         its general partner


By:  /s/ Terry Feeney                       By:  /s/ Terry Feeney
   ----------------------------------          ---------------------------------
   Name:  Terry Feeney                         Name:  Terry Feeney
   Title: Chief Operating Officer              Title: Chief Operating Officer


                                            MILLENNIUM MANAGEMENT, L.L.C.
   /s/ Israel A. Englander by Simon
Lorne pursuant to Power of Attorney
filed with SEC on June 6, 2005              By:  /s/ Terry Feeney
-------------------------------------          ---------------------------------
ISRAEL A. ENGLANDER                            Name:  Terry Feeney
                                               Title: Chief Operating Officer