Ownership Submission
FORM 3
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  Rudio Daniel
2. Date of Event Requiring Statement (Month/Day/Year)
04/01/2011
3. Issuer Name and Ticker or Trading Symbol
ENDO PHARMACEUTICALS HOLDINGS INC [ENDP]
(Last)
(First)
(Middle)
C/O ENDO PHARMACEUTICALS, 100 ENDO BLVD.
4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
Vice President, Controller
5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

CHADDS FORD, PA 19317
6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)
2. Amount of Securities Beneficially Owned
(Instr. 4)
3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)
4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock, par value, $.01 per share 907
D
 
2007 Stock Incentive Plan Restricted Stock Units (RSUs) (1) 350
D
 
2007 Stock Incentive Plan Restricted Stock Units (RSUs) (2) 1,040
D
 
2007 Stock Incentive Plan Restricted Stock Units (RSUs) (3) 1,446
D
 
2010 Stock Incentive Plan Restricted Stock Units (RSUs) (4) 1,288
D
 

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)
2. Date Exercisable and Expiration Date
(Month/Day/Year)
3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)
4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)
6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
2004 Stock Incentive Plan Stock Options (NQ)   (5) 02/21/2018 Common Stock 851 $ 25.19 D  
2004 Stock Incentive Plan Stock Options (NQ)   (6) 02/26/2019 Common Stock 2,698 $ 19.93 D  
2007 Stock Incentive Plan Stock Options (NQ)   (7) 02/19/2020 Common Stock 4,105 $ 20.61 D  
2010 Stock Incentive Plan Stock Options (NQ)   (8) 02/23/2021 Common Stock 4,017 $ 33.98 D  

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
Rudio Daniel
C/O ENDO PHARMACEUTICALS
100 ENDO BLVD.
CHADDS FORD, PA 19317
      Vice President, Controller  

Signatures

/s/ Caroline B. Manogue, by Power of Attorney 04/11/2011
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) These restricted stock units (RSUs) vest over a four-year period, 25% on February 21, 2009, 25% February 21, 2010, 25% on February 21, 2011 and 25% on February 21, 2012.
(2) These restricted stock units (RSUs) vest over a four-year period, 25% on February 26, 2010, 25% February 26, 2011, 25% on February 26, 2012 and 25% on February 26, 2013.
(3) These restricted stock units (RSUs) vest over a four-year period, 25% on February 19, 2011, 25% February 19, 2012, 25% on February 19, 2013 and 25% on February 19, 2014.
(4) These restricted stock units (RSUs) vest over a four-year period, 25% on February 23, 2012, 25% February 23, 2013, 25% on February 23, 2014 and 25% on February 23, 2015.
(5) These stock options are exercisable 25% per year on each of February 21, 2009, February 21, 2010, February 21, 2011 and February 21, 2012.
(6) These stock options are exercisable 25% per year on each of February 26, 2010, February 26, 2011, February 26, 2012 and February 26, 2013.
(7) These stock options are exercisable 25% per year on each of February 19, 2011, February 19, 2012, February 19, 2013 and February 19, 2014.
(8) These stock options are exercisable 25% per year on each of February 23, 2012, February 23, 2013, February 23, 2014 and February 23, 2015.

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