Ownership Submission
FORM 3
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  Garbacz Stephen
 2. Date of Event Requiring Statement (Month/Day/Year)
10/01/2014		 3. Issuer Name and Ticker or Trading Symbol
Epizyme, Inc. [EPZM]
(Last)
(First)
(Middle)
C/O EPIZYME, INC., 400 TECHNOLOGY SQUARE		 4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
Principal Accounting Officer
 5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

CAMBRIDGE, MA 02139		 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)		 2. Amount of Securities Beneficially Owned
(Instr. 4)		 3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)		 4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock, par value $0.0001 per share 13,073
D
 

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)		 2. Date Exercisable and Expiration Date
(Month/Day/Year)		 3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)		 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)		 6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option (Right to Buy)   (1) 10/02/2022 Common Stock 23,438 $ 2.19 D  
Stock Option (Right to Buy)   (2) 01/24/2023 Common Stock 18,745 $ 3.54 D  
Stock Option (Right to Buy)   (3) 09/02/2023 Common Stock 15,000 $ 28.04 D  
Stock Option (Right to Buy)   (4) 01/27/2024 Common Stock 14,000 $ 31.2 D  

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
Garbacz Stephen
C/O EPIZYME, INC.
400 TECHNOLOGY SQUARE
CAMBRIDGE, MA 02139		       Principal Accounting Officer  

Signatures

/s/ Stephen Garbacz 10/01/2014
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) This option was granted on October 3, 2012 with respect to 41,666 shares of Common Stock, with 25% vesting on October 3, 2013 and the remaining 75% vesting in 36 substantially equal monthly installments thereafter.
(2) This option was granted on January 25, 2013 with respect to 25,700 shares of Common Stock, with 25% vesting on January 25, 2014 and the remaining 75% vesting in 36 substantially equal monthly installments thereafter.
(3) This option was granted on September 3, 2013 with respect to 15,000 shares of Common Stock, with 25% vesting on September 3, 2014 and the remaining 75% vesting in 36 substantially equal monthly installments thereafter.
(4) This option was granted on January 28, 2014 with respect to 14,000 shares of Common Stock, with 25% vesting on January 28, 2015 and the remaining 75% vesting in 36 substantially equal monthly installments thereafter.

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