SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13G

                    Under the Securities Exchange Act of 1934
                               (Amendment No. 1)*

                           CIPHERGEN BIOSYSTEMS, INC.
                                (Name of Issuer)

                          Common Stock, $.001 Par Value
                         (Title of Class of Securities)

                                   17252Y 10 4
                                 (CUSIP Number)


Check the following box if a fee is being paid with this statement [ ]. (A fee
is not required only if the filing person: (1) has a previous statement on the
file reporting beneficial ownership of more than five percent of the class of
securities described in Item 1; and (2) has no amendment subsequent thereto
reporting beneficial ownership of five percent or less of such class.) (See Rule
13d-7.)

*The remainder of this cover page shall be filled our for a reporting person's
initial filing of this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).

                        (Continued on following page(s))

                             CUSIP NO. 17252Y 10 4

17252Y 10 4                         13G

1        NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
         GlaxoSmithKline plc

2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

                                                 (a)  [  ]
                                                 (b)  [  ]

3        SEC USE ONLY

4        CITIZENSHIP OR PLACE OF ORGANIZATION
         England and Wales

                                            5        SOLE VOTING POWER
  NUMBER OF                                          1,941,162

  SHARES
BENEFICIALLY                                6       SHARED VOTING POWER
 OWNED BY
   EACH
 REPORTING                                  7       SOLE DISPOSITIVE POWER
  PERSON                                            1,941,162
  WITH

                                            8        SHARED DISPOSITIVE POWER

9        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         1,941,162

10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
         [  ]

11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

         7.2%

12       TYPE OF REPORTING PERSON*
         CO

                      *SEE INSTRUCTION BEFORE FILLING OUT!

CUSIP NO. 17252Y 10 4                       13G

Item 1.           (a).     Name of Issuer:


                  (b).     Address of Issuer's Principal Executive Offices:



Item 2.           (a).     Names of Person Filing:

                           GlaxoSmithKline plc

                  (b).     Address of Principal Business Office:

                           980 Great West Road
                           Brentford
                           Middlesex
                           TW8 9GS  ENGLAND

                  (c).     Citizenship:

                           England and Wales

                  (d).     Title of Class of Securities:


                  (e).     CUSIP Number:


Item 3.                    Not Applicable.


Item 4.                    Ownership.

                           The information in items 1 and 5 through 11 on the
                           cover pages (page 2) on Schedule 13G is hereby
                           incorporated by reference.

Item 5.                    Ownership of Five Percent or Less of a Class:

                           If this statement is being filed to report the fact
                           that as of the date hereof the reporting person has
                           ceased to be the beneficial owner of more than five
                           percent of the class of securities, check the
                           following [ ].

Item 6.                    Ownership of More Than Five Percent on Behalf of
                           Another Person:

                           S.R. One, Limited ("SRO") is an indirect,
                           wholly-owned subsidiary of Reporting Person and owner
                           of record of 1,941,162 Ciphergen shares:

                           SRO sold 9,675 shares on March 12, 2001. In July
                           2001, SRO exercised stock options to acquire 6,450
                           shares. Options over another 2,150 shares lapsed as
                           those options were not vested on the date that the
                           SRO representative resigned from the Issuer's Board
                           of Directors.

Item 7.                    Identification and Classification of Subsidiaries
                           Which Acquired the Security Being Reported on by the
                           Parent Holding Company:

                           Not applicable.

Item 8.                    Identification and Classification of Members of the
                           Group:

                           Not applicable.

Item 9.                    Notice of Dissolution of Group:

                           Not Applicable

Item 10.                   Certification:

                           By signing below I certify that, to the best of my
                           knowledge and belief, the securities referred to
                           above were acquired and are not held for the purpose
                           of or with the effect of changing or influencing the
                           control of the issuer of such securities and were not
                           acquired in connection with or as a participant in
                           any transaction having such purpose or effect.

                           Signature:

                           After reasonable inquiry and to the best of my
                           knowledge and belief, I certify that the information
                           set

                           forth in this statement is true, complete and
                           correct.

                                                GLAXOSMITHKLINE PLC

                                                By:   /s/ S.M. Bicknell
                                                    -------------------
                                                         S.M. Bicknell
                                                         Company Secretary

Dated:  February 13, 2002