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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 14A
Proxy Statement Pursuant to Section 14(a) of the Securities
Exchange Act of 1934 (Amendment No.)
Filed by the Registrant          þ
Filed by a Party other than the Registrant     o
Check the appropriate box:
o      Preliminary Proxy Statement
o      Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))
þ      Definitive Proxy Statement
o      Definitive Additional Materials
o      Soliciting Material Pursuant to §240.14a-12
ARADIGM CORPORATION
 
(Name of Registrant as Specified In Its Charter)
 
(Name of Person(s) Filing Proxy Statement, if other than the Registrant)
Payment of Filing Fee (Check the appropriate box):
þ   No fee required.
 
o   Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.
  (1)   Title of each class of securities to which transaction applies:
 
     
 
  (2)   Aggregate number of securities to which transaction applies:
 
     
 
  (3)   Per unit price or other underlying value of transaction computed pursuant to Exchange Act Rule a-II (set forth the amount on which the filing fee is calculated and state how it was determined):
 
     
 
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o   Fee paid previously with preliminary materials.
 
o   Check box if any part of the fee is offset as provided by Exchange Act Rule a-II(a)(2) and identify the filing for which the offsetting fee was paid previously. Identify the previous filing by registration statement number, or the Form or Schedule and the date of its filing.
  (6)   Amount Previously Paid:
 
  (7)   Form, Schedule or Registration Statement No.:
 
     
 
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  (9)   Date Filed:
 
     
 

 


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ARADIGM CORPORATION
3929 Point Eden Way
Hayward, California, 94545
 
NOTICE OF ANNUAL MEETING OF SHAREHOLDERS
To Be Held On May 15, 2009
 
Dear Shareholder:
 
You are cordially invited to attend the Annual Meeting of Shareholders of Aradigm Corporation, a California corporation (“Aradigm”). The meeting will be held on Friday, May 15, 2009, at 9:00 a.m. local time at Aradigm’s offices for the following purposes:
 
1. To elect the four nominees for director named herein to serve until the next annual meeting of shareholders and until their successors are duly elected and qualified.
 
2. To approve an amendment to Aradigm’s Employee Stock Purchase Plan to increase the aggregate number of shares of Common Stock authorized for issuance under such plan by 2,500,000 shares.
 
3. To ratify the selection of Odenberg, Ullakko, Muranishi & Co. LLP as Aradigm’s independent registered public accounting firm for the fiscal year ending December 31, 2009.
 
4. To conduct any other business properly brought before the meeting.
 
These items of business are more fully described in the Proxy Statement accompanying this Notice.
 
The record date for the annual meeting is March 31, 2009. Only shareholders of record at the close of business on that date may vote at the meeting or any adjournment thereof.
 
By Order of the Board of Directors
 
-s- IGOR GONDA
Igor Gonda, Ph.D.
President and Chief Executive Officer
 
Hayward, California
April 9, 2009
 
 
Important Notice Regarding the Availability of Proxy Materials for the Shareholders’ Meeting to Be Held on May 15, 2009 at 9:00 am at 3929 Point Eden Way, Hayward, California, 94545
 
The proxy statement and annual report to shareholders are available at www.aradigm.com.
 
 
You are cordially invited to attend the meeting in person. Whether or not you expect to attend the meeting, please complete, date, sign and return the enclosed proxy as promptly as possible in order to ensure your representation at the meeting. A return envelope (which is postage prepaid if mailed in the United States) has been provided for your convenience. Even if you have voted by proxy, you may still vote in person if you attend the meeting. Please note, however, that if your shares are held of record by a broker, bank or other nominee and you wish to vote at the meeting, you must obtain a proxy issued in your name from that record holder.


 

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ARADIGM CORPORATION
3929 Point Eden Way
Hayward, California, 94545
 
PROXY STATEMENT FOR ANNUAL MEETING OF SHAREHOLDERS
To Be Held On May 15, 2009
 
QUESTIONS AND ANSWERS ABOUT THIS PROXY MATERIAL AND VOTING
 
Why am I receiving these materials?
 
We have sent you these proxy materials because the Board of Directors of Aradigm Corporation is soliciting your proxy to vote at the 2009 Annual Meeting of Shareholders. You are invited to attend the annual meeting to vote on the proposals described in this proxy statement. However, you do not need to attend the meeting to vote your shares. Instead, you may simply complete, sign and return the enclosed proxy card.
 
We intend to mail these proxy materials on or about April 9, 2009 to all shareholders of record entitled to vote at the annual meeting.
 
Who can vote at the annual meeting?
 
Only shareholders of record at the close of business on March 31, 2009 will be entitled to vote at the annual meeting. On this record date, there were 99,899,455 shares of Common Stock outstanding and entitled to vote.
 
Shareholder of Record: Shares Registered in Your Name
 
If on March 31, 2009 your shares were registered directly in your name with our transfer agent, Computershare Trust Company, N.A., then you are a shareholder of record. As a shareholder of record, you may vote in person at the meeting or vote by proxy. Whether or not you plan to attend the meeting, we urge you to fill out and return the enclosed proxy card to ensure your vote is counted.
 
Beneficial Owner: Shares Registered in the Name of a Broker or Bank
 
If on March 31, 2009 your shares were held in an account at a brokerage firm, bank, dealer, or other similar organization, then you are the beneficial owner of shares held in “street name” and these proxy materials are being forwarded to you by that organization. The organization holding your account is considered the shareholder of record for purposes of voting at the annual meeting. As a beneficial owner, you have the right to direct your broker or other agent regarding how to vote the shares in your account. You are also invited to attend the annual meeting. However, since you are not the shareholder of record, you may not vote your shares in person at the meeting unless you request and obtain a valid proxy from your broker or other agent.
 
What am I voting on?
 
There are three matters scheduled for a vote:
 
  •  Election of four directors;
 
  •  Approval of an amendment to Aradigm’s Employee Stock Purchase Plan (the “Purchase Plan”) to increase the aggregate number of shares of Common Stock authorized for issuance under such plan by 2,500,000 shares; and
 
  •  Ratification of selection by the Audit Committee of the Board of Directors of Odenberg, Ullakko, Muranishi & Co. LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2009.


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How do I vote?
 
You may either vote “For” all the nominees for director or you may “Withhold” your vote for any nominee you specify. For each of the other matters to be voted on, you may vote “For” or “Against” or abstain from voting. The procedures for voting are fairly simple:
 
Shareholder of Record: Shares Registered in Your Name
 
If you are a shareholder of record, you may vote in person at the annual meeting or vote by proxy using the enclosed proxy card. Whether or not you plan to attend the meeting, we urge you to vote by proxy to ensure your vote is counted. You may still attend the meeting and vote in person even if you have already voted by proxy.
 
  •  To vote in person, come to the annual meeting and we will give you a ballot when you arrive.
 
  •  To vote using the proxy card, simply complete, sign and date the enclosed proxy card and return it promptly in the envelope provided. If you return your signed proxy card to us before the annual meeting, we will vote your shares as you direct.
 
Beneficial Owner: Shares Registered in the Name of Broker or Bank
 
If you are a beneficial owner of shares registered in the name of your broker, bank, or other agent, you should have received a proxy card and voting instructions with these proxy materials from that organization rather than from Aradigm. Simply complete and mail the proxy card to ensure that your vote is counted. To vote in person at the annual meeting, you must obtain a valid proxy from your broker, bank, or other agent. Follow the instructions from your broker or bank included with these proxy materials, or contact your broker or bank to request a proxy form.
 
How many votes do I have?
 
On each matter to be voted upon, you have one vote for each share of Common Stock you own as of March 31, 2009. However, you may be able to cumulate your votes for Proposal 1, the election of directors, if at least one shareholder gives notice at the meeting, before the voting, that he or she intends to cumulate votes. Under cumulative voting, you have four votes for each share of Common Stock you own. You may cast all of your votes for one candidate, or you may distribute your votes among different candidates as you choose. However, you may cumulate votes (cast more than one vote per share) for a candidate only if the candidate is nominated before the voting and at least one shareholder gives notice at the meeting, before the voting, that he or she intends to cumulate votes. If you do not specify how to distribute your votes, by giving your proxy you are authorizing the proxyholders (the individuals named on your proxy card) to cumulate votes in their discretion.
 
What if I return a proxy card or otherwise vote but do not make specific choices?
 
If you return a signed and dated proxy card or otherwise vote without marking any voting selections, your shares will be voted, as applicable “For” the election of all four nominees for director, “For” the amendment to the Purchase Plan and “For” the ratification of Odenberg, Ullakko, Muranishi & Co. LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2009. If any other matter is properly presented at the meeting, your proxyholder (one of the individuals named on your proxy card) will vote your shares using his or her best judgment.
 
Who is paying for this proxy solicitation?
 
We will pay for the entire cost of soliciting proxies. In addition to these proxy materials, our directors and employees and Georgeson Shareholder Communications, Inc. (“Georgeson”) may also solicit proxies in person, by telephone, or by other means of communication. Directors and employees will not be paid any additional compensation for soliciting proxies, but Georgeson, if retained, would be paid its customary fee, estimated to be $10,000 plus out-of-pocket expenses, if it solicits proxies.


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What does it mean if I receive more than one set of proxy materials?
 
If you receive more than one set of proxy materials, your shares may be registered in more than one name or in different accounts. Please follow the voting instructions on the proxy cards and proxy materials to ensure that all of your shares are voted.
 
Can I change my vote after submitting my proxy?
 
Yes. You can revoke your proxy at any time before the final vote at the meeting. If you are the record holder of the shares, you may revoke your proxy in any one of following ways:
 
  •  You may submit another properly completed proxy card with a later date.
 
  •  You may send a timely written notice that you are revoking your proxy to our Secretary at 3929 Point Eden Way, Hayward, California, 94545.
 
  •  You may attend the annual meeting and vote in person. Simply attending the meeting will not, by itself, revoke your proxy.
 
Your most current proxy card is the one that is counted.
 
If your shares are held by your broker or bank as a nominee or agent, you should follow the instructions provided by your broker or bank.
 
When are shareholder proposals due for next year’s annual meeting?
 
To be considered for inclusion in next year’s proxy materials, your proposal must be submitted in writing by December 21, 2009, to our Secretary at 3929 Point Eden Way, Hayward, California, 94545. If you wish to submit a proposal that is not to be included in next year’s proxy materials or nominate a director, you must do so no later than the close of business on March 16, 2010 and no earlier than the close of business on February 16, 2010. You are also advised to review our bylaws, which contain additional requirements about advance notice of shareholder proposals and director nominations. A copy of our bylaws is available via written request to our Secretary at 3929 Point Eden Way, Hayward, California, 94545, or by accessing EDGAR on the SEC’s website at www.sec.gov.
 
How are votes counted?
 
Votes will be counted by the inspector of election appointed for the meeting, who will separately count “For” and (with respect to proposals other than the election of directors) “Against” votes, abstentions and broker non-votes. Abstentions and broker non-votes will not be counted towards the vote total for any proposal.
 
If your shares are held by your broker as your nominee (that is, in “street name”), you will need to obtain a proxy form from the institution that holds your shares and follow the instructions included on that form regarding how to instruct your broker to vote your shares. If you do not give instructions to your broker, your broker can vote your shares with respect to “discretionary” items, but not with respect to “non-discretionary” items. On non-discretionary items for which you do not give your broker instructions, the shares will be treated as broker non-votes.
 
What are broker non-votes?
 
Broker non-votes occur when a beneficial owner of shares held in “street name” does not give instructions to the broker or nominee holding the shares as to how to vote on matters deemed “non-routine.” Generally, if shares are held in street name, the beneficial owner of the shares is entitled to give voting instructions to the broker or nominee holding the shares. If the beneficial owner does not provide voting instructions, the broker or nominee can still vote the shares with respect to matters that are considered to be “routine,” but not with respect to “non-routine” matters. Under the rules and interpretations of the New York Stock Exchange, “non-routine” matters are generally those involving a contest or a matter that may substantially affect the rights or privileges of shareholders, such as mergers or shareholder proposals.


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How many votes are needed to approve each proposal?
 
  •  For the election of directors, the four nominees receiving the most “For” votes (from the holders of votes of shares present in person or represented by proxy and entitled to vote on the election of directors) will be elected. Broker non-votes will have no effect.
 
  •  To be approved, Proposal 2 (approval of an amendment to our purchase plan to increase the aggregate number of shares of Common Stock authorized for issuance under such plan by 2,500,000 shares), must receive “For” votes from the holders of a majority of shares present either in person or by proxy and entitled to vote. Broker non-votes will have no effect.
 
  •  To be approved, Proposal 3 (ratifying the selection of Odenberg, Ullakko, Muranishi & Co. LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2009) must receive “For” votes from the holders of a majority of shares present either in person or by proxy and entitled to vote. Abstentions and broker non-votes will have no effect.
 
What is the quorum requirement?
 
A quorum of shareholders is necessary to hold a valid meeting. A quorum will be present if shareholders holding a majority of the outstanding shares are present at the meeting in person or represented by proxy. On the record date, there were 99,899,455 shares of Common Stock outstanding and entitled to vote. Thus, the holders of 49,949,728 shares must be present in person or represented by proxy at the meeting or by proxy to have a quorum.
 
Your shares will be counted towards the quorum only if you submit a valid proxy (or one is submitted on your behalf by your broker, bank or other nominee) or vote at the meeting. Abstentions and broker non-votes will be counted towards the quorum requirement. If there is no quorum, the holders of a majority of the shares present in person or represented by proxy at the meeting may adjourn the meeting to another date.
 
How can I find out the results of the voting at the annual meeting?
 
Preliminary voting results will be announced at the annual meeting. Final voting results will be published in our quarterly report on Form 10-Q for the second quarter of 2009.
 
What proxy materials are available on the internet?
 
The proxy statement and Form 10-K are available at www.aradigm.com.
 
PROPOSAL 1
 
ELECTION OF DIRECTORS
 
Our Board of Directors (the “Board”) currently consists of four directors. There are four nominees for director this year. Each director to be elected will hold office until the next annual meeting and until his successor is elected, or until the director’s death, resignation or removal. Each of the nominees listed below is currently a member of our Board who was previously elected by the shareholders. It is our policy to invite nominees to attend the annual meeting and to encourage attendance at meetings at which substantial shareholder attendance is expected. All of the nominees for election as a director at the 2008 Annual Meeting of Shareholders attended the 2008 Annual Meeting of Shareholders, with the exception of John M. Siebert.
 
The four candidates receiving the highest number of affirmative votes by the holders of shares entitled to be voted will be elected. Shares represented by executed proxies will be voted, if authority to do so is not withheld, for the election of the four nominees named below. If any nominee becomes unavailable for election as a result of an unexpected occurrence, your shares will be voted for the election of a substitute nominee proposed by us. Each person nominated for election has agreed to serve if elected. Our management has no reason to believe that any nominee will be unable to serve.


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Nominees
 
The following is a brief biography of each nominee for director and their ages as of March 31, 2009.
 
             
Name
 
Age
 
Principal Occupation/Position Held With Us
 
Frank H. Barker
    78     Director
Igor Gonda
    61     President, Chief Executive Officer and Director
John M. Siebert
    69     Director
Virgil D. Thompson
    69     Chairman and Director
 
Frank H. Barker has been a director since May 1999. From January 1980 to January 1994, Mr. Barker served as a company group chairman of Johnson & Johnson, Inc., a diversified health care company, and was Corporate Vice President from January 1989 to January 1996. Mr. Barker retired from Johnson & Johnson, Inc. in January 1996. Mr. Barker holds a B.A. in Business Administration from Rollins College, Winter Park, Florida. Mr. Barker is a director of Jenex Corporation, a Canadian medical devices company.
 
Igor Gonda, Ph.D. has served as our President and Chief Executive Officer since August 2006, and as a director since September 2001. From December 2001 to August 2006, Dr. Gonda was the Chief Executive Officer and Managing Director of Acrux Limited, a publicly traded specialty pharmaceutical company located in Melbourne, Australia. From July 2001 to December 2001, Dr. Gonda was our Chief Scientific Officer and, from October 1995 to July 2001, was our Vice President, Research and Development. From February 1992 to September 1995, Dr. Gonda was a Senior Scientist and Group Leader at Genentech, Inc. His key responsibilities at Genentech were the development of the inhalation delivery of rhDNase (Pulmozyme) for the treatment of cystic fibrosis and non-parenteral methods of delivery of biologics. Prior to that, Dr. Gonda held academic positions at the University of Aston in Birmingham, United Kingdom, and the University of Sydney, Australia. Dr. Gonda holds a B.Sc. in Chemistry and a Ph.D. in Physical Chemistry from Leeds University, United Kingdom. Dr. Gonda was the Chairman of our Scientific Advisory Board until August 2006.
 
John M. Siebert, Ph.D. has been a director since November 2006. From May 2003 to October 2008, Dr. Siebert was the Chairman and Chief Executive Officer of CyDex Pharmaceuticals, Inc., a privately held specialty pharmaceutical company. From September 1995 to April 2003, he was President and Chief Executive Officer of CIMA Labs Inc., a publicly traded drug delivery company, and from July 1995 to September 1995 he was President and Chief Operating Officer of CIMA Labs. From 1992 to 1995, Dr. Siebert was Vice President, Technical Affairs at Dey Laboratories, Inc., a privately held pharmaceutical company. From 1988 to 1992, he worked at Bayer Corporation. Prior to that, Dr. Siebert was employed by E.R. Squibb & Sons, Inc., G.D. Searle & Co. and The Procter & Gamble Company. Dr Siebert holds a B.S. in Chemistry from Illinois Benedictine University, an M.S. in Organic Chemistry from Wichita State University and a Ph.D. in Organic Chemistry from the University of Missouri.
 
Virgil D. Thompson has been a director since June 1995 and has been Chairman of the Board since January 2005. From November 2002 until July 2007, Mr. Thompson was President and Chief Executive Officer of Angstrom Pharmaceuticals, Inc., a privately held pharmaceutical company where he continues to serve as a director. From September 2000 to November 2002, Mr. Thompson was President, Chief Executive Officer and a director of Chimeric Therapies, Inc., a privately held biotechnology company. From May 1999 until September 2000, Mr. Thompson was the President, Chief Operating Officer and a director of Savient Pharmaceuticals, a publicly traded specialty pharmaceutical company. From January 1996 to April 1999, Mr. Thompson was the President and Chief Executive Officer and a director of Cytel Corporation, a publicly traded biopharmaceutical company that was subsequently acquired by IDM Pharma, Inc. From 1994 to 1996, Mr. Thompson was President and Chief Executive Officer of Cibus Pharmaceuticals, Inc., a privately held drug delivery device company. From 1991 to 1993, Mr. Thompson was President of Syntex Laboratories, Inc., a U.S. subsidiary of Syntex Corporation, a publicly traded pharmaceutical company. Mr. Thompson holds a B.S. in Pharmacy from Kansas University and a J.D. from The George Washington University Law School. Mr. Thompson is chairman of the board of directors of Questcor Pharmaceuticals, Inc., a publicly traded pharmaceutical company, and is a director of Savient Pharmaceuticals.
 
THE BOARD OF DIRECTORS RECOMMENDS
A VOTE IN FAVOR OF EACH NAMED NOMINEE.


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Independence of the Board of Directors
 
We have chosen to apply the listing standards of the Nasdaq Global Market (“Nasdaq”) in determining the independence of our directors. The Board consults with counsel to ensure that the Board’s determinations are consistent with all relevant securities and other laws and regulations regarding the definition of “independent,” including those set forth in pertinent listing standards of the Nasdaq, as in effect from time to time.
 
Consistent with these considerations, after review of all relevant transactions or relationships between each director and nominee for director, or any of his family members, and us, our senior management and our independent registered public accounting firm, the Board affirmatively has determined that the following three directors and nominees for directors are independent within the meaning of the applicable Nasdaq listing standards: Mr. Barker, Dr. Siebert, and Mr. Thompson. In making this determination, the Board found that none of these directors or nominees for director had a material or disqualifying relationship with the Company. Dr. Gonda, our President and Chief Executive Officer, is not an independent director within the meaning of the applicable Nasdaq standards by virtue of his employment with Aradigm. In addition, each person who served as a director for any portion of 2008 was independent within the meaning of the applicable Nasdaq listing standards, except for Dr. Gonda.
 
Meetings of the Board of Directors
 
The Board held 22 meetings during the last fiscal year. Each of our current Board members attended 75% or more of the aggregate of the meetings of the Board and of the committees on which he served, held during the period for which he was a director or committee member, respectively.
 
In fiscal 2008 our independent directors met or held telephonic Board meetings nine times in regularly scheduled executive sessions at which only independent directors were present. These meetings were chaired by Mr. Thompson, the Chairman of the Board. Persons interested in communicating with the independent directors with their concerns or issues may address correspondence to a particular director, or to the independent directors generally, in care of Aradigm at 3929 Point Eden Way, Hayward, California, 94545.
 
Shareholder Communications with the Board of Directors
 
We have implemented a process by which shareholders may communicate with the Board or any of its directors. Shareholders who wish to communicate with the Board may do so by sending written communications addressed to the Secretary of Aradigm at 3929 Point Eden Way, Hayward, California 94545. All communications will be compiled by our Secretary and submitted to the Board or the individual directors on a periodic basis. All communications directed to the Audit Committee in accordance with our whistleblower policy that relate to questionable accounting or auditing matters involving us will be forwarded directly to the Audit Committee.
 
Code of Ethics
 
We have adopted the Aradigm Corporation Code of Business Conduct and Ethics that applies to all of our officers, directors and employees. The Code of Business Conduct and Ethics is available on our website at www.aradigm.com. If we make any substantive amendments to the Code of Business Conduct and Ethics or grant any waiver from a provision of the Code to any executive officer or director, we will promptly disclose the nature of the amendment or waiver on our website.


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Information Regarding the Committees of our Board of Directors
 
The Board has three committees: an Audit Committee, a Compensation Committee and a Nominating and Corporate Governance Committee (formerly called the Nominating Committee). The following table provides membership information and meeting information for each of the Board committees during 2008:
 
                         
            Nominating and
            Corporate
Name
  Audit   Compensation   Governance
 
Frank H. Barker
    X               X *
Igor Gonda
                       
Stephen Jaeger(1)
    X *     X          
Timothy Lynch(2)
    X *     X          
John M. Siebert
            X       X  
Virgil D. Thompson
    X       X *     X  
Total meetings in fiscal year 2008
    5       7       3  
 
 
Committee Chairperson
 
(1) Mr. Jaeger did not stand for re-election at the 2008 Annual Meeting and his membership on the Audit Committee and Compensation Committee ended upon the election of the new Board at the meeting.
 
(2) Mr. Lynch resigned from the Board on February 17, 2009. He served on the Audit Committee and Compensation Committee from May 15, 2008 until his resignation.
 
Below is a description of each committee of the Board. The Board has determined that each member of each committee meets the applicable Nasdaq rules and regulations regarding “independence” and that each member is free of any relationship that would impair his individual exercise of independent judgment with regard to Aradigm.
 
Audit Committee
 
The Audit Committee of the Board was established by the Board in accordance with Section 3(a)(58)(A) of the Securities Exchange Act of 1934, as amended, to oversee our corporate accounting and financial reporting processes and audits of our financial statements. For this purpose, the Audit Committee performs several functions. The Audit Committee evaluates the performance of and assesses the qualifications of our independent registered public accounting firm; determines and approves the engagement of our independent registered public accounting firm; determines whether to retain or terminate the existing independent registered public accounting firm or to appoint and engage a new independent registered public accounting firm; reviews and approves the retention of the independent registered public accounting firm to perform any proposed permissible non-audit services; monitors the rotation of partners of the independent registered public accounting firm on our audit engagement team as required by law; confers with management and our independent registered public accounting firm regarding the effectiveness of internal controls over financial reporting; establishes procedures, as required under applicable law, for the receipt, retention and treatment of complaints received by us regarding accounting, internal accounting controls or auditing matters and the confidential and anonymous submission by employees of concerns regarding questionable accounting or auditing matters; reviews the financial statements to be included in our Annual Report on Form 10-K and our quarterly financial statements on Form 10-Q; and discusses with management and our independent registered public accounting firm the results of the annual audit. Currently, three directors comprise the Audit Committee: Messrs. Barker and Thompson and Dr. Siebert (chair). The Audit Committee is governed by a written charter that is available to shareholders on our website at www.aradigm.com.
 
The Board annually reviews the Nasdaq listing standards definition of independence for Audit Committee members and has determined that all members of our Audit Committee are independent (as independence is currently defined in Rule 4350(d)(2)(A)(i) and (ii) of the Nasdaq listing standards). The Board has determined that Dr. Siebert qualifies as an “audit committee financial expert,” as defined in applicable rules of the Securities and Exchange Commission (the “SEC”). The Board made a qualitative assessment of Dr. Siebert’s level of knowledge and experience based on a number of factors, including formal education and executive experience.


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Compensation Committee
 
The Compensation Committee of the Board reviews and recommends to the Board the overall compensation strategy and policies for us. The Compensation Committee reviews and recommends to the Board corporate performance goals and objectives relevant to the compensation of our executive officers and other senior management; reviews and recommends to the Board the compensation and other terms of employment of our Chief Executive Officer; reviews and recommends to the Board for approval the compensation and other terms of employment of the other officers; and oversees the administration of our stock option and purchase plans, pension and profit sharing plans, stock bonus plans, deferred compensation plans and other similar programs. Three directors currently comprise the Compensation Committee: Messrs. Barker and Thompson (chair) and Dr. Siebert. All members of our Compensation Committee are independent (as independence is currently defined in Rule 4200(a)(15) of the Nasdaq listing standards). The Compensation Committee is governed by a written charter that is available to shareholders on our website at www.aradigm.com.
 
Nominating and Corporate Governance Committee
 
The Nominating and Corporate Governance Committee of the Board is responsible for identifying, reviewing and evaluating candidates to serve as directors (consistent with criteria approved by the Board), recommending to the Board candidates for election and re-election to the Board, making recommendations to the Board regarding the membership of the committees of the Board, assessing the performance of the Board and its committees and monitoring compliance with our Code of Business Conduct and Ethics. Currently, the Nominating and Corporate Governance Committee consists of three directors: Dr. Siebert and Messrs. Barker (chair) and Thompson. All current members of the Nominating and Corporate Governance Committee are independent (as independence is currently defined in Rule 4200(a)(15) of the Nasdaq listing standards). The Nominating and Corporate Governance Committee is governed by a written charter that is available to shareholders on our website at www.aradigm.com.
 
Any potential candidates for director nominees, including candidates recommended by shareholders, are reviewed in the context of the current composition of the Board, our operating requirements and the long-term interests of shareholders. In conducting this assessment, the Committee considers such factors as it deems appropriate given our current needs and those of our Board, to maintain a balance of knowledge, experience and capability. The Nominating and Corporate Governance Committee reviews directors’ overall service during their term, including the number of meetings attended, level of participation and quality of performance. The Committee also determines whether the nominee would be independent, which determination is based upon applicable Nasdaq listing standards, applicable SEC rules and regulations and the advice of counsel, if necessary. The Committee then compiles a list of potential candidates from suggestions it may receive, but may also engage, if it deems appropriate, a professional search firm to generate additional suggestions. The Committee conducts any appropriate and necessary inquiries into the backgrounds and qualifications of possible candidates as it deems appropriate. The Committee meets to discuss and consider such candidates’ qualifications and then selects a nominee for recommendation to the Board by majority vote. In 2008 the Nominating and Corporate Governance Committee authorized the payment of a fee to a third party to assist in the process of identifying and evaluating director candidates. While the Committee and the Board have from time to time received and considered suggestions from shareholders for nominations to the Board, the Committee has received no suggestions for which disclosure is required in this proxy statement.
 
The Nominating and Corporate Governance Committee will consider director candidates recommended by shareholders. The Committee will consider candidates recommended by shareholders in the same manner as it considers recommendations from other sources. Shareholders who wish to recommend individuals for consideration by the Nominating and Corporate Governance Committee to become nominees for election to the Board may do so by delivering a written recommendation to the Nominating and Corporate Governance Committee at the following address: 3929 Point Eden Way, Hayward, California 94545 at least 60 days prior, but no more than 90 days prior, to the anniversary date of the last annual meeting of shareholders. Submissions should include the full name of the proposed nominee, a description of the proposed nominee’s business experience for at least the previous five years, complete biographical information, a description of the proposed nominee’s qualifications as a director and a representation that the nominating shareholder is a beneficial or record owner of our stock.


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REPORT OF THE AUDIT COMMITTEE OF THE BOARD OF DIRECTORS (*)
 
The Audit Committee has reviewed and discussed the audited financial statements for the fiscal year ended December 31, 2008 with our management. The Audit Committee has discussed with the independent registered public accounting firm the matters required to be discussed by Statement on Auditing Standards No. 114, The Auditor’s Communication with Those Charged with Governance, as adopted by the Public Company Accounting Oversight Board (“PCAOB”) in Rule 3200T. The Audit Committee has also received the written disclosures and the letter from the independent registered public accounting firm required by applicable requirements of the PCAOB regarding the independent registered public accounting firm’s communications with the audit committee concerning independence, and has discussed with the independent registered public accounting firm the independent registered public accounting firm’s independence. Based on the foregoing, the Audit Committee has recommended to the Board of Directors that the audited financial statements be included in the Company’s Annual Report on Form 10-K for the fiscal year ended December 31, 2008.
 
From the members of the Audit Committee of Aradigm Corporation:
 
Frank H. Barker
John M. Siebert, (Chair)
Virgil D. Thompson
 
PROPOSAL 2
 
APPROVAL OF EMPLOYEE STOCK PURCHASE PLAN, AS AMENDED
 
In April 1996, the Board of Directors adopted, and the shareholders subsequently approved, the Employee Stock Purchase Plan (“Purchase Plan”). A total of 2,050,000 shares of the Company’s Common Stock have previously been authorized for issuance under the Purchase Plan. At February 28, 2009, an aggregate of 1,110,084 shares had been issued under the Purchase Plan and 939,916 shares remained for the grant of future rights under the Purchase Plan.
 
During the last fiscal year, shares were purchased at prices ranging from $0.33 to $0.94 in the following amounts under the Purchase Plan: all current executive officers as a group (58,146 shares), and all employees (excluding current executive officers) as a group (242,378 shares).
 
In February 2009, the Board of Directors of the Company adopted an amendment to the Purchase Plan, subject to shareholder approval, to increase the number of shares authorized for issuance under the Purchase Plan by 2,500,000 to 4,550,000 shares. This amendment is intended to afford the Company greater flexibility in providing employees with stock incentives and ensures that the Company can continue to provide such incentives at levels determined appropriate by the Board.
 
The following summary description of the Purchase Plan, as amended, is qualified in its entirety by reference to the full text of the Purchase Plan that is attached as Appendix A to the proxy statement filed via EDGAR with the SEC, including all changes that this proposal would effect if approved by our shareholders at the annual meeting.
 
Shareholders are requested in this Proposal 2 to approve the Purchase Plan, as amended. The affirmative vote of the holders of a majority of the shares present in person or represented by proxy and voting at the meeting (which shares voting affirmatively also constitute at least a majority of the required quorum) will be required to approve the Purchase Plan, as amended. For purposes of this vote abstentions and broker non-votes will not be counted for any purpose in determining whether this matter has been approved.
 
THE BOARD OF DIRECTORS RECOMMENDS
A VOTE IN FAVOR OF PROPOSAL 2.
 
 
   (*) The material in this report is not “soliciting material,” is not deemed “filed” with the SEC, and is not to be incorporated by reference into any filing of the Company under the Securities Act of 1933, as amended, or the Securities Act of 1934, as amended, whether made before or after the date hereof and irrespective of any general incorporation language contained in such filing.


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The essential features of the Purchase Plan, as amended, are outlined below:
 
Purpose
 
The purpose of the Purchase Plan is to provide a means by which employees of the Company (and any parent or subsidiary of the Company designated by the Board of Directors to participate in the Purchase Plan) may be given an opportunity to purchase Common Stock of the Company through payroll deductions, to assist the Company in retaining the services of its employees, to secure and retain the services of new employees, and to provide incentives for such persons to exert maximum efforts for the success of the Company. At March 31, 2009, all of the Company’s approximately 36 employees were eligible to participate in the Purchase Plan.
 
The rights to purchase Common Stock granted under the Purchase Plan are intended to qualify as options issued under an “employee stock purchase plan” as that term is defined in Section 423(b) of the Code.
 
Administration
 
The Purchase Plan is administered by the Board of Directors, which has the final power to construe and interpret the Purchase Plan and the rights granted under it. The Board has the power, subject to the provisions of the Purchase Plan, to determine when and how rights to purchase Common Stock of the Company will be granted, the provisions of each offering of such rights (which need not be identical), and whether any parent or subsidiary of the Company shall be eligible to participate in such plan. The Board has the power, which it has not exercised, to delegate administration of such plan to a committee of not less than two Board members. The Board may abolish any such committee at any time and revest in itself the administration of the Purchase Plan.
 
Offerings
 
The Purchase Plan is implemented by offerings of rights to all eligible employees from time to time by the Board. Generally, each such offering is two years in duration. The Board may set the duration of an offering for a period of time not to exceed 27 months.
 
Eligibility
 
Any person who is customarily employed at least 20 hours per week and five months per calendar year by the Company (or by any parent or subsidiary of the Company designated from time to time by the Board) on the first day of an offering period is eligible to participate in that offering under the Purchase Plan, provided such employee has been in the continuous employ of the Company for at least 10 days preceding the first day of the offering period.
 
Notwithstanding the foregoing, no employee is eligible for the grant of any rights under the Purchase Plan if, immediately after such grant, the employee would own, directly or indirectly, stock possessing 5% or more of the total combined voting power or value of all classes of stock of the Company or of any parent or subsidiary of the Company (including any stock which such employee may purchase under all outstanding rights and options), nor will any employee be granted rights that would permit him or her to buy more than $25,000 worth of stock (determined at the fair market value of the shares at the time such rights are granted) under all employee stock purchase plans of the Company in any calendar year.
 
Participation in the Plan
 
Eligible employees become participants in the Purchase Plan by delivering to the Company, prior to the date selected by the Board as the offering date for the offering, an agreement authorizing payroll deductions of up to 15% of such employee’s total compensation during the purchase period.
 
Purchase Price
 
The purchase price per share at which shares are sold in an offering under the Purchase Plan is the lower of (i) 85% of the fair market value of a share of Common Stock on the date of commencement of the offering, or (ii) 85% of the fair market value of a share of Common Stock on any purchase date.


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Payment of Purchase Price; Payroll Deductions
 
The purchase price of the shares is accumulated by payroll deductions over the offering period. At any time during the purchase period, a participant may reduce or terminate his or her payroll deductions. A participant may not increase or begin such payroll deductions after the beginning of any purchase period, except, if the Board provides, in the case of an employee who first becomes eligible to participate as of a date specified during the purchase period. All payroll deductions made for a participant are credited to his or her account under the Purchase Plan and deposited with the general funds of the Company. A participant may not make any additional payments into such account.
 
Purchase of Stock
 
By executing an agreement to participate in the Purchase Plan, the employee is entitled to purchase shares under such plan. In connection with offerings made under the Purchase Plan, the Board specifies a maximum number of shares any employee may be granted the right to purchase and the maximum aggregate number of shares which may be purchased pursuant to such offering by all participants. If the aggregate number of shares to be purchased upon exercise of rights granted in the offering would exceed the maximum aggregate number, the Board would make a pro rata allocation of shares available in a uniform and equitable manner. Unless the employee’s participation is discontinued, his or her right to purchase shares is exercised automatically at the end of the purchase period at the applicable price. See “Withdrawal” below.
 
Withdrawal
 
While each participant in the Purchase Plan is required to sign an agreement authorizing payroll deductions, the participant may withdraw from a given offering by terminating his or her payroll deductions and by delivering to the Company a notice of withdrawal from the Purchase Plan. Such withdrawal may be elected at any time prior to the end of the applicable offering period.
 
Upon any withdrawal from an offering by the employee, the Company will distribute to the employee his or her accumulated payroll deductions without interest, less any accumulated deductions previously applied to the purchase of stock on the employee’s behalf during such offering, and such employee’s interest in the offering will be automatically terminated. The employee is not entitled to again participate in such offering. An employee’s withdrawal from an offering will not have any effect upon such employee’s eligibility to participate in subsequent offerings under the Purchase Plan.
 
Termination of Employment
 
Rights granted pursuant to any offering under the Purchase Plan terminate immediately upon cessation of an employee’s employment for any reason, and the Company will distribute to such employee all of his or her accumulated payroll deductions, without interest.
 
Restrictions on Transfer
 
Rights granted under the Purchase Plan are not transferable and may be exercised only by the person to whom such rights are granted.
 
Duration, Amendment and Termination
 
The Board may, in its discretion, suspend or terminate the Purchase Plan at any time.
 
The Board may amend the Purchase Plan at any time. Any amendment of the Purchase Plan must be approved by the shareholders within 12 months of its adoption by the Board if the amendment would (i) increase the number of shares of Common Stock reserved for issuance under the Purchase Plan, (ii) modify the requirements relating to eligibility for participation in the Purchase Plan, or (iii) modify any other provision of the Purchase Plan in a manner that would materially increase the benefits accruing to participants under the Purchase Plan, if such approval is required in order to comply with the requirements of Rule 16b-3 under the Exchange Act.


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Rights granted before amendment or termination of the Purchase Plan will not be altered or impaired by any amendment or termination of such plan without consent of the person to whom such rights were granted.
 
Effect of Certain Corporate Events
 
In the event of a dissolution, liquidation or specified type of merger of the Company, the surviving corporation either will assume the rights under the Purchase Plan or substitute similar rights, or the exercise date of any ongoing offering will be accelerated such that the outstanding rights may be exercised immediately prior to, or concurrent with, any such event.
 
Stock Subject to Purchase Plan
 
If rights granted under the Purchase Plan expire, lapse or otherwise terminate without being exercised, the Common Stock not purchased under such rights again becomes available for issuance under such plan.
 
Federal Income Tax Information
 
Rights granted under the Purchase Plan are intended to qualify for favorable federal income tax treatment associated with rights granted under an employee stock purchase plan which qualifies under provisions of Section 423 of the Code.
 
A participant will be taxed on amounts withheld for the purchase of shares as if such amounts were actually received. Other than this, no income will be taxable to a participant until disposition of the shares acquired, and the method of taxation will depend upon the holding period of the purchased shares.
 
If the stock is disposed of at least two years after the beginning of the offering period and at least one year after the stock is transferred to the participant, then the lesser of (i) the excess of the fair market value of the stock at the time of such disposition over the purchase price or (ii) the excess of the fair market value of the stock as of the beginning of the offering period over the purchase price (determined as of the beginning of the offering period) will be treated as ordinary income. Any further gain or any loss will be taxed as a capital gain or loss. Capital gains currently are generally subject to lower tax rates than ordinary income.
 
If the stock is sold or disposed of before the expiration of either of the holding periods described above, then the excess of the fair market value of the stock on the purchase date over the purchase price will be treated as ordinary income at the time of such disposition, and the Company may, in the future, be required to withhold income taxes relating to such ordinary income from other payments made to the participant. The balance of any gain will be treated as capital gain. Even if the stock is later disposed of for less than its fair market value on the purchase date, the same amount of ordinary income is attributed to the participant, and a capital loss is recognized equal to the difference between the sales price and the fair market value of the stock on such purchase date.
 
There are no federal income tax consequences to the Company by reason of the grant or purchase of rights under the Purchase Plan. The Company is entitled to a deduction to the extent amounts are taxed as ordinary income to a participant (subject to the requirement of reasonableness, the provisions of Section 162(m) and the satisfaction of a tax reporting obligation).


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Equity Compensation Plan Information
 
Equity Compensation Plan Information
 
The following table summarizes our equity compensation plan information as of December 31, 2008. Information is included for the equity compensation plans approved by our shareholders. There are no equity compensation plans not approved by our shareholders.
 
                         
            Common Stock
            Available for
            Future Issuance
    Common Stock to be
  Weighted-Average
  Under Equity
    Issued Upon Exercise of
  Exercise Price of
  Compensation Plans
    Outstanding Options
  Outstanding Options
  (Excluding Securities
Plan Category
  and Rights   and Rights   Reflected in Column(a))
    (a)   (b)   (c)
 
Equity compensation plans approved by Aradigm shareholders
    4,185,061 (1)   $ 4.14       4,927,515 (2)
Equity compensation plans not approved by Aradigm shareholders
                 
 
 
(1) Issued pursuant to the Company’s 1996 Equity Incentive Plan, the 1996 Non-Employee Directors’ Plan, and the 2005 Equity Incentive Plan.
 
(2) Shares available for future issuance includes 939,916 shares reserved under Employee Stock Purchase Plan.
 
PROPOSAL 3
 
RATIFICATION OF SELECTION OF INDEPENDENT REGISTERED
PUBLIC ACCOUNTING FIRM
 
The Audit Committee of the Board of Directors has selected Odenberg, Ullakko, Muranishi & Co. LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2009 and has further directed that management submit the selection of an independent registered public accounting firm for ratification by our shareholders at the annual meeting. Prior to the selection of Odenberg, Ullakko, Muranishi & Co. LLP as our independent registered public accounting firm in April 2007, Ernst & Young LLP had audited our financial statements, since 1995. Representatives of Odenberg, Ullakko, Muranishi & Co. LLP are expected to be present at the annual meeting. They will have an opportunity to make a statement if they so desire and will be available to respond to appropriate questions.
 
Neither our bylaws nor other governing documents or law require shareholder ratification of the selection of Odenberg, Ullakko, Muranishi & Co. LLP as our independent registered public accounting firm. However, the Audit Committee is submitting the selection of Odenberg, Ullakko, Muranishi & Co. LLP to the shareholders for ratification as a matter of good corporate practice. If the shareholders fail to ratify the selection, the Audit Committee will reconsider whether or not to retain that firm. Even if the selection is ratified, the Audit Committee in its discretion may direct the appointment of a different independent registered public accounting firm at any time during the year if they determine that such a change would be in the best interests of Aradigm and its shareholders.
 
The affirmative vote of the holders of a majority of the shares present in person or represented by proxy and voting at the annual meeting (which shares voting affirmatively also constitute a majority of the required quorum) will be required to ratify the selection of Odenberg, Ullakko, Muranishi & Co. LLP. For purposes of this vote, abstentions and broker non-votes will not be counted for any purpose in determining whether this matter has been approved.


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Principal Accountant Fees and Services
 
The following table represents aggregate fees billed to us for fiscal years ended December 31, 2008 and 2007, by Odenberg, Ullakko, Muranishi & Co. LLP, our independent registered public accounting firm since April 2007, and Ernst & Young LLP, our independent registered public accountant firm for the first four months of 2007. All services described below were pre-approved by the Audit Committee.
 
                 
    Fiscal Year Ended
 
    December 31,  
    2008     2007  
    (In thousands)  
 
Audit Fees(1)
  $ 271     $ 371  
Audit-related Fees
           
Tax Fees
    46        
All Other Fees
          28  
                 
Total Fees
  $ 317     $ 399  
                 
 
 
(1) Audit fees represent fees for professional services related to the performance of the audit of our annual financial statements, review of our quarterly financial statements and consents on SEC filings.
 
Pre-Approval Policies and Procedures
 
The Audit Committee pre-approves audit services, audit-related services and non-audit services provided by our independent registered public accounting firm, Odenberg, Ullakko, Muranishi & Co. LLP, and will not approve services that the Audit Committee determines are outside the bounds of applicable laws and regulations. Pre-approval may also be given as part of the Audit Committee’s approval of the scope of the engagement of the independent registered public accounting firm or on an individual explicit case-by-case basis before the independent registered public accounting firm is engaged to provide each service. The pre-approval of services may be delegated to one or more of the Audit Committee’s members, but the decision must be reported to the full Audit Committee at its next scheduled meeting.
 
The Audit Committee has determined that the rendering of the services, other than audit services, by Odenberg, Ullakko, Muranishi & Co. LLP is compatible with maintaining the principal accountant’s independence.
 
Change in Independent Registered Public Accounting Firm
 
Effective as of April 12, 2007, the Audit Committee dismissed Ernst & Young LLP as our independent registered public accounting firm. On the same date, the Audit Committee engaged Odenberg, Ullakko, Muranishi & Co. LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2007.
 
In connection with Ernst & Young LLP’s audits for the interim period between January 1, 2007 and April 12, 2007, there were no disagreements with Ernst & Young LLP on any matter of accounting principles or practices, financial statement disclosure, or auditing scope or procedure, which disagreements, if not resolved to the satisfaction of Ernst & Young LLP, would have caused Ernst & Young LLP to make reference to the subject matter of such disagreements in connection with its reports. In addition, no reportable events, as defined in Item 304(a)(1)(v) of Regulation S-K, occurred during our the interim period between January 1, 2007 and April 12, 2007.
 
Prior to April 12, 2007, neither we nor anyone on our behalf has consulted with Odenberg, Ullakko, Muranishi & Co. LLP regarding either (i) the application of accounting principles to a specified transaction, either completed or proposed; or the type of audit opinion that might be rendered on our financial statements, and neither a written report was provided to us nor oral advice was provided by Odenberg, Ullakko, Muranishi & Co. LLP that was an important factor considered by us in reaching a decision as to any accounting, auditing or financial reporting issue; or (ii) any matter that was the subject of a disagreement, as that term is defined in Item 304 (a)(1)(iv) of Regulation S-K and the related instructions to Item 304 of Regulation S-K, or a reportable event, as that term is defined in Item 304 (a)(1)(v) of Regulation S-K.
 
THE BOARD OF DIRECTORS RECOMMENDS
A VOTE IN FAVOR OF PROPOSAL 3.


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SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT
 
The following table sets forth certain information regarding the ownership of our common stock as of February 28, 2009 by: (i) each director and nominee for director; (ii) each of the executive officers named in the Summary Compensation Table (provided below); (iii) all of our executive officers and directors as a group; and (iv) all those known by us to be beneficial owners of more than five percent of our common stock.
 
                 
    Beneficial Ownership Common(1)  
    Number of
    Percent of
 
    Shares     Total (%)  
 
Arnhold and S. Bleichroeder Advisers, LLC. and related entities(2)
1345 Avenue of the Americas
New York, NY 10105
    38,064,005       38.18  
The Conus Fund LP and related entities(3)
49 West 38th Street, 11th Floor
New York, NY 10018
    9,458,491       9.49  
Highbridge International LLC and related entities(4)
9 West 57th Street, 27th Floor
New York, NY 10019
    9,087,991       9.11  
Laurence W. Lytton(5)
467 Central Park West, #17-A
New York, NY 10025
    5,829,303       5.85  
Igor Gonda, Ph.D.(6)
    715,476       *  
Nancy Pecota(7)
    47,500       *  
D. Jeffery Grimes(8)
    170,125       *  
Babatunde A. Otulana, M.D.(9)
    497,017       *  
Norman Halleen(10)
    0       *  
Virgil D. Thompson(11)
    151,250       *  
Frank H. Barker(12)
    127,543       *  
John M. Siebert, Ph.D.(13)
    69,000       *  
All executive officers and directors as a group (6 persons)(14)
    1,280,894       1.28  
 
 
Less than one percent
 
(1) This table is based upon information supplied by officers, directors and principal shareholders and Forms 4 and Schedules 13D and 13G filed with the Securities and Exchange Commission (“SEC”). Unless otherwise indicated in the footnotes to this table and subject to community property laws where applicable, we believe that each of the shareholders named in this table has sole voting and investment power with respect to the shares indicated as beneficially owned. Applicable percentages are based on 99,704,455 shares of common stock outstanding on February 28, 2009, adjusted as required by rules promulgated by the SEC. Unless otherwise indicated, the address of each person on this table is c/o Aradigm Corporation, 3929 Point Eden Way, Hayward, California, 94545.
 
(2) Based upon information contained in a Schedule 13G Amendment No. 4 and Form 3, each filed with the SEC on March 5, 2009, Arnhold and S. Bleichroeder, LLC (ASB), an investment adviser registered under Section 203 of the Investment Advisers Act of 1940, is deemed to be the beneficial owner of 38,064,005 shares or 38.18% of the Common Stock believed to be outstanding as a result of acting as investment advisor to various clients. Clients of ASB have the right to receive and the ultimate power to direct the receipt of dividends from, or the proceeds of the sale of, such securities. First Eagle Value in Biotechnology Master Fund, Ltd. (“FEVBM”), a Cayman Islands company for which ASB acts as investment adviser, may be deemed to beneficially own 14,298,624 of these 38,064,005 shares, which equates to 14.34% of the Common Stock. In addition, 21 April Fund, Ltd., a Cayman islands company for which ASB acts as investment adviser, may be deemed to beneficially own 9,870,442 of the 38,064,005 shares, which equates to 9.90% of the Common Stock. Finally, DEF Associates N.V., a Netherlands Antilles company for which ASB acts as investment


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adviser, may be deemed to beneficially own 5,000,000 of the 38,064,005 shares, or 5.01% of the Common Stock.
 
(3) The Conus Fund LP and related entities (“Conus”) have not yet made a filing under Section 13 of the Securities Exchange Act of 1934, as amended. The information reflected for Conus is as of February 28, 2009 and is based solely upon information contained in an Investor Questionnaire provided to us by Conus in connection with our registered direct offerings that were completed in February 2009.
 
(4) The information reflected for Highbridge International LLC and related entities (“Highbridge”) is as of February 28, 2009 and is based upon (i) information contained in an Investor Questionnaire provided to us by Highbridge in connection with our registered direct offerings that were completed in February 2009 and (ii) a Schedule 13G Amendment No. 1, as filed with the SEC on February 9, 2009.
 
(5) Based upon information contained in a Schedule 13G filed with the SEC on March 6, 2009, Laurence W. Lytton has sole voting and dispositive power over 5,829,303 shares.
 
(6) Includes 550,643 shares of common stock subject to options exercisable within 60 days of February 28, 2009. Does not include 300,000 shares that may be acquired only upon the occurrence of certain future events pursuant to a restricted stock bonus agreement between Dr. Gonda and Aradigm.
 
(7) Includes 12,500 shares of common stock subject to options exercisable within 60 days of February 28, 2009.
 
(8) Includes 67,812 shares of common stock subject to options exercisable within 60 days of February 28, 2009.
 
(9) Includes 488,999 shares of common stock subject to options exercisable within 60 days of February 28, 2009. Dr. Otulana ceased serving as our Chief Medical Officer on December 31, 2008. Does not include 150,000 shares that may be acquired only upon the occurrence of certain future events pursuant to a restricted stock bonus agreement between Dr. Otulana and Aradigm.
 
(10) Mr. Halleen ceased serving as our interim chief financial officer on September 30, 2008.
 
(11) Includes 147,350 shares of common stock subject to options exercisable within 60 days of February 28, 2009.
 
(12) Includes 87,543 shares of common stock subject to options exercisable within 60 days of February 28, 2009.
 
(13) Includes 65,000 shares of common stock subject to options exercisable within 60 days of February 28, 2009.
 
(14) See footnotes (6) through (8), (11) through (13) above.
 
Section 16(a) Beneficial Ownership Reporting Compliance
 
Section 16(a) of the 1934 Act requires our directors and executive officers, and persons who own more than ten percent of a registered class of our equity securities, to file with the SEC initial reports of ownership and reports of changes in ownership of our common stock and other equity securities. Officers, directors and greater than ten percent shareholders are required by SEC regulation to furnish us with copies of all Section 16(a) forms they file.
 
To our knowledge, based solely on a review of the copies of such reports furnished to us and written representations that no other reports were required, during the fiscal year ended December 31, 2008, all Section 16(a) filing requirements applicable to our officers, directors and greater than ten percent beneficial owners were complied with, other than two Forms 4, covering four transactions, were filed late for Mr. Barker, two Forms 4, covering two transactions, were filed late for Mr. Lynch and one Form 4, covering one transaction, was filed late for each of Dr. Siebert and Mr. Thompson.


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COMPENSATION
 
The policies of the Compensation Committee, or the Committee, with respect to the compensation of executive officers, including the Chief Executive Officer, or CEO, are designed to provide compensation sufficient to attract, motivate and retain executives of outstanding ability and potential and to establish an appropriate relationship between executive compensation and the creation of shareholder value. To meet these goals, the Committee recommends executive compensation packages to our board of directors that are based on a mix of salary, bonus and equity awards.
 
Overall, the board and the Committee seek to provide total compensation packages that are competitive in terms of total potential value to our executives, and that are tailored to the unique characteristics of our company in order to create an executive compensation program that will adequately reward our executives for their roles in creating value for our shareholders. The board and the Committee intend to provide executive compensation packages that are competitive with other similarly situated companies in our industry. Historically, the board and the Committee generally weighted executives’ compensation packages more heavily in favor of equity-based compensation versus salary, as they believe performance and equity-based compensation is important to maintain a strong link between executive incentives and the creation of shareholder value. The board and the Committee believe that performance and equity-based compensation are the most important component of the total executive compensation package for maximizing shareholder value while, at the same time, attracting, motivating and retaining high-quality executives. For 2009, the board and the Committee continued their emphasis on equity-based compensation. Given the company’s current financial situation and market capitalization , the state of the equity markets, the company’s proposed business plans and the recent reduction in headcount, the board and the Committee viewed the company as analogous to a “start-up” company and believed that a focus on equity-based compensation was even more important as a tool to motivate the company’s executive officers.
 
The board and the Committee have reviewed this Compensation Discussion and Analysis with the company’s management.
 
Benchmarking of Compensation Practices
 
The board and the Committee believe it is important when making compensation-related decisions to be informed as to current practices of similarly situated publicly held companies in the life sciences industry. Beginning in late 2008, given the board and Committee’s focus on equity-based compensation, the board and the Committee retained a consultant to review equity-based compensation of executives in the biotechnology industry. The consultant prepared a study reviewing the equity-based compensation practices of 120 publicly held biotechnology companies with market capitalizations of between $50 and $400 million. In addition to this benchmarking study, the board and the Committee take into account input from other sources, including past benchmarking studies, input from other independent members of the board of directors and publicly available data relating to the compensation practices and policies of other companies within and outside of our industry. For example, in late 2007, the board and the Committee reviewed several publicly available broad-based studies of cash and equity compensation paid to executives at up to 575 publicly held companies in the life sciences industry and, in late 2006, the Committee reviewed a special study of the compensation practices of 19 publicly held life sciences companies that were chosen based on business characteristics similar to ours.
 
Benchmarking studies were used primarily in making compensation decisions for Dr. Igor Gonda, our CEO, Ms. Nancy Pecota, our Vice President, Finance, and Chief Financial Officer, and Mr. D. Jeffery Grimes, our Vice President of Legal Affairs, General Counsel & Secretary. Given the company’s operating performance and continued need for capital, in 2009 the board and the Committee retained total cash compensation for these three executive officers at the same level as paid in 2008. Based on the board and Committee’s last annual review of total cash compensation, the board and Committee believe these salaries are substantially equivalent to the median cash compensation paid by comparable companies in the life sciences industry. Consistent with the board’s and the Committee’s greater emphasis on equity-based compensation, in 2009 they sought to establish equity compensation for these three executive officers at a level approximately equal to the equity-based compensation paid by 75% of comparable companies in the life sciences industry, based on the survey conducted in late 2008.


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While benchmarking may not always be appropriate as a stand-alone tool for setting compensation due to the aspects of our business and objectives that may be unique to us, the board and the Committee generally believe that gathering this information is an important part of their compensation-related decision-making process.
 
The Committee has in the past retained and may in the future retain the services of third-party executive compensation specialists, as the Committee sees fit, in connection with the establishment of compensation and related policies.
 
Compensation Components
 
Base Salary.  Generally, the board and the Committee believe that executive base salaries should be set near the median of the range of salaries for executives in similar positions and with similar responsibilities at comparable companies. The board and the Committee believe that maintaining base salary amounts at or near the industry median minimizes competitive disadvantage while conserving the company’s cash resources and avoiding paying amounts in excess of what they believe to be necessary to motivate executives to meet corporate goals. Base salaries are typically reviewed annually. In the past, management has presented the Committee with its initial recommendations for executive salary levels and the Committee and board have determined whether to adjust these base salary recommendations to realign such salaries with median market levels after taking into account individual responsibilities, performance, experience as well as the benchmarking data reviewed by the Committee.
 
For 2008, the board, upon recommendation of the Committee, established base salaries for Dr. Gonda, Ms. Pecota and Mr. Grimes of $380,000, $238,000 and $230,000, respectively. For 2009, management recommended to the board and Committee that base salaries for Dr. Gonda, Ms. Pecota and Mr. Grimes be retained at their 2008 levels. Given the company’s financial position, management felt, and the board agreed, that an increase in base salary for 2009 was not appropriate.
 
Annual Executive Bonus Plan.
 
In addition to base salaries, the board and the Committee believe that performance-based cash bonuses can play an important role in providing incentives to our executives to achieve defined annual corporate goals. Prior to or near the beginning of each year, the board, upon the recommendation of the Committee, reviews the target bonus amount (defined as a set percentage of base salary) for each executive. The target bonus amount is set at a level that, upon achievement of 100% of the target goals, will result in bonus payments that the board and the Committee believe to be at or near the median level for target bonus amounts for comparable companies included in the benchmark studies and that, upon achievement beyond the target goals, can result in bonuses of up to 150% of the target bonus amount.
 
The Committee also reviews a detailed set of overall corporate performance goals (target goals) prepared by management that are intended to apply to the executives’ bonus awards and, with some distinctions, to the bonus awards for all of our other employees. The Committee then works with management to develop final corporate performance goals that are set at a level the Committee believes management can reasonably achieve over the next year. For each individual corporate goal, the Committee establishes relative weights and then sets target performance for Level 1 satisfaction (50% of target payout for that goal), Level 2 satisfaction (100% of target payout for that goal) and Level 3 satisfaction (150% of target payout for that goal) of the corporate goal, with the attainment of each specified level of performance tied to a specific percentage payout of the target bonus amount for that goal. The relative weights for each individual corporate goal may be changed by the board during the year as a result of external and internal events and their impact upon the company.
 
The goals are designed to lead to results that will maximize shareholder value. For example, at the start of 2007, the board and Committee concluded that the company’s stock price undervalued the company. In response, the Committee developed a corporate goal and appropriately weighted the goal to reward management for a significant increase in the company’s stock price. Similarly, the board and Committee determined that the ARD-3100 program would likely drive the company’s value in 2007 and 2008, and so in those years they weighted the goal related to development of the ARD-3100 program higher than the other operational performance goals.


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At the end of each year, the board, upon the recommendation of the Committee, determines the level of achievement for each corporate goal, on a goal by goal basis, and awards credit for the achievement of goals as a percentage of the target bonus. Final determinations as to bonus levels are then based on the achievement of these corporate goals, which are the same for all executives, as well as the board’s and the Committee’s assessment as to the overall success of the company and the development of the business.
 
Actual bonuses are targeted to be paid to the executives at the end of each fiscal year and may be above or below target bonus levels, at the discretion of the board. While the board and Committee retain full discretion as to the amount, if any, of bonus compensation paid to executives, the Committee strives to develop corporate goals that are objective and reliably measurable to deemphasize the need for subjective discretion. The board and Committee strive to limit their discretionary authority to unusual circumstances. For example, in 2006, the Committee only awarded a partial bonus at the end of 2006 and awarded the remaining portion of the bonus in February 2007 after the successful completion of the company’s follow-on public offering. The board and Committee felt that given the company’s cash position and the overall development of its business in 2006, successful completion of the follow-on public offering was an essential component of the executives’ performance for the year.
 
Bonus payments under the annual bonus plan are contingent on continued employment with the company at the end of the year.
 
In 2008, the board, upon recommendation of the Committee, established 2008 target bonus awards (as a percentage of base salary) of 50% for Dr. Gonda, 40% for Ms. Pecota and 30% for Mr. Grimes. For 2008, the Committee determined that the executives’ bonus awards would be earned based on the achievement of specified corporate performance goals, including meeting various milestones related to the development of the inhaled liposomal ciprofloxacin, inhaled treprostinil, and inhaled combination products programs, reaching certain milestones for in- and out-licensing of products in support of the company’s product pipeline, reaching a certain level of manufacturing capabilities with a third-party contract manufacturer, and the amount of the Company’s cash burn for the 2008 fiscal year.
 
In January 2009, the board and Committee determined the executive team had satisfied corporate goals to a level that would have entitled them to a payout of 60% of their target bonus amounts. Management recommended to the board and Committee not to pay the executives a bonus for 2008. Management felt, and the board agreed, that given the company’s cash position, the recent reduction in force and the current economic climate, a bonus was not appropriate.
 
In January 2009, the board, upon recommendation of the Committee, established 2009 target bonus awards (as a percentage of base salary) of 50% for Dr. Gonda and 40% for Ms. Pecota and Mr. Grimes. For 2009, the Committee will determine the specific corporate performance goals to be achieved for the executives’ bonus awards to be earned.
 
Actual bonus awards for 2009 will be determined at the end of the year and may be above or below the target bonus levels, at the discretion of the board and the Committee.
 
Equity Awards.  The board and the Committee believe that providing a significant portion of our executives’ total compensation package in stock options and restricted stock awards aligns the incentives of our executives with the interests of our shareholders and with our long-term success. The board and the Committee develop their equity award determinations based on their judgments as to whether the complete compensation packages provided to our executives, including prior equity awards, are sufficient to retain, motivate and adequately award the executives. As discussed above, the primary component of this judgment is based on information provided by benchmarking studies. The board and the Committee seek to establish equity compensation for our three executive officers at a level approximately equal to the equity-based compensation paid by 75% of the companies in the surveys. Initial equity award grants are proposed to the Committee by management and the board and the Committee then work with management to ensure the award grants are at a level the board and the Committee feel are appropriate.
 
We grant equity awards through our 2005 Equity Incentive Plan, which was adopted by our board and shareholders to permit the grant of stock options, stock appreciation rights, restricted shares, restricted stock units, performance shares and other stock-based awards to our officers, directors, scientific advisory board members, employees and consultants. All of our employees, directors, scientific advisory board members and consultants are


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eligible to participate in the 2005 Equity Incentive Plan. The material terms of the 2005 Equity Incentive Plan are further described in note 7 to our financial statements included in our Annual Report that is enclosed with these proxy materials on Form 10-K. All options we grant have an exercise price equal to the fair market value of our common stock on the date of grant.
 
For 2009, the board and Committee decided to grant equity awards as a combination of stock options and restricted stock awards. The stock options vest quarterly over four years and the restricted stock awards vest annually over two years. The awards were allocated with roughly two-thirds of the target grant amount as stock options and one-third of the target grant amount as restricted stock. However, the board and Committee determined that the restricted stock award have a higher value to the executives, and as a rough approximation of the difference in value the board and Committee valued a restricted stock award for one share as three times the value of a stock option to purchase one share. Accordingly, if the board and Committee had determined to grant an executive an award with a value equivalent to an option to purchase 100,000 shares of our stock, the actual allocation of the award between stock options and restricted stock would have resulted in the grant of a stock option to purchase about 67,000 shares and a restricted stock award of about 11,000 shares.
 
In January 2009, the Committee granted Dr. Gonda, Ms. Pecota and Mr. Grimes options to purchase 350,000, 200,000 and 200,000 shares of our common stock, respectively, and restricted stock awards for 80,000, 35,000 and 35,000 shares of our common stock, respectively.
 
The Committee felt that the 2009 equity awards were necessary to bring our executives’ equity compensation levels at a level the Committee believes is necessary to retain a talented and capable management team. The Committee anticipates making future refresh equity award grants to executives annually, subject to its discretion. The Committee believes this award structure is consistent with our executive compensation policies.
 
Severance Benefits.  The board, upon recommendation of the Committee, previously adopted an Amended and Restated Executive Officer Severance Plan, dated as of December 31, 2008, and approved change of control agreements with each of our executive officers, the terms of which are more fully described below in the section entitled “Potential Payments Upon Termination or Change in Control.” The board and the Committee believe these severance and change in control benefits are an essential element of our executive compensation package and assist us in recruiting and retaining talented individuals. Our business is inherently risky and the board and the Committee believe the severance benefits encourage our executives to take necessary but reasonable business risks to increase shareholder value. The board and the Committee believe the change of control benefits align our executives’ interests more greatly in favor of corporate liquidity events that can be potentially valuable to our shareholders. They have established these severance and change of control benefits at levels that they feel are comparable to benefits offered to executives in similar positions and with similar responsibilities at comparable companies.
 
Other Compensation.  All of our executives are eligible to participate in our employee benefit plans, including medical, dental, life insurance and 401(k) plans. These plans are available to all employees and do not discriminate in favor of executive officers. It is generally our policy to not extend significant perquisites to our executives that are not available to our employees generally. We have no current plans to make changes to levels of benefits and perquisites provided to executives.


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Summary Compensation Table
 
The following table sets forth information regarding compensation earned in 2008, 2007, and 2006 by our CEO, Chief Financial Officer, Vice President of Legal Affairs, our former Chief Medical Officer and our former Interim Chief Financial Officer (these individuals are collectively referred to as our “named executive officers”):
 
                                                                 
                        Non-Equity
       
                Stock
  Option
  Incentive Plan
  All Other
   
        Salary
  Bonus
  Awards(1)
  Awards(1)
  Compensation
  Compensation
  Total
    Year   ($)   ($)   ($)   ($)   ($)   ($)   ($)
 
Igor Gonda, Ph.D(2)
    2008       380,000             53,002       266,197             25,101       724,300  
President and Chief
    2007       320,000             62,187       174,439       172,000       73,404       802,030  
Executive Officer
    2006       113,230       100,000       20,310       68,942       22,363       50,966       375,841  
Nancy Pecota(3)
    2008       66,823                   2,472             1,760       71,055  
Vice President and Chief
Financial Officer
                                                               
D. Jeffery Grimes(4)
    2008       226,716             15,464       18,358             15,233       275,771  
Vice President of Legal Affairs
                                                               
Former Executive Officer
                                                               
Norman Halleen(5)
    2008       202,500                               6,037       208,537  
Former Interim Chief
    2007       130,645                               3,837       134,482  
Financial Officer
                                                               
Babatunde A. Otulana, M.D.(6)
    2008       322,000             19,531       224,085             252,615       818,231  
Former Senior Vice President of
    2007       289,000             1,418       240,501       124,270       59,855       715,044  
Development and Chief Medical Officer
    2006       287,038                   183,319       45,352       22,980       538,689  
 
 
(1) The method of and assumptions used to calculate the value of stock awards and option awards granted to our named executive officers is discussed in Note 7 of the notes to our financial statements included in our Annual Report on Form 10-K.
 
(2) Dr. Gonda commenced his employment with us on August 10, 2006. Dr. Gonda’s bonus reflects a $100,000 signing bonus for accepting his offer of employment. In 2006, Dr. Gonda also received a stock bonus award for up to 100,000 shares of our common stock. We valued Dr. Gonda’s stock bonus on a Monte-Carlo simulation due to the path-dependency of the award. We believe that the Monte-Carlo simulation provides a more precise estimate for the grant date fair value of a market-based equity award as the simulation allows for vesting throughout the vesting period. In accordance with Securities and Exchange Commission regulations, the cost reflected in the table above only includes the portion of the award’s value that was amortized for 2006, 2007 and 2008. Dr. Gonda’s compensation includes $21,000 in director fees and options expense of $2,485 that were both attributable to his services as a director prior to his appointment as our CEO in August 2006. Dr. Gonda has not received any additional compensation for his services as a director since he was appointed CEO in August 2006.
 
(3) Ms. Pecota was appointed as an officer on September 22, 2008.
 
(4) Mr. Grimes was appointed as an officer on July 1, 2008.
 
(5) Mr. Halleen ceased serving as an officer effective September 30, 2008.
 
(6) Dr. Otulana ceased serving as an officer effective December 31, 2008.


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All Other Compensation in the summary compensation table above includes the following components:
 
                                                                                         
        Club
  Health
      Life
  401(k)
  Employee
  Vacation
           
        Member-
  Care
  Moving
  Insurance
  Matching
  Stock
  Benefits
  Director
  Severance
   
        ships
  Contribution
  Allowance
  Premiums
  Contributions
  Purchase
  Paid
  Fees
  Benefits
  Total
Name
  Year   ($)   ($)   ($)   ($)   ($)   ($)   ($)   ($)   ($)   ($)
 
Igor Gonda, Ph.D. 
    2008       350       11,933             2,100       7,750       2,968                         25,101  
      2007       300       12,117       46,286       1,815       6,889       5,997                         73,404  
      2006       350       3,386       23,304       595       2,331                   21,000             50,966  
Nancy Pecota
    2008             286             375       1,098                               1,760  
D. Jeffery Grimes
    2008       350       3,048             1,281       6,567       3,987                         15,233  
Former Executive Officers
                                                                                       
Norman Halleen
    2008             6,037                                                 6,037  
      2007             3,837                                                 3,837  
Babatunde A. Otulana, M.D. 
    2008             8,361             2,029       6,905             24,700             210,621       252,615  
      2007       350       18,102             1,642       6,415             33,346                   59,855  
      2006       350       14,855             1,613       6,162                               22,980  
 
2008 Grants of Plan-Based Awards
 
The following table sets forth information regarding plan-based awards to our named executive officers in 2008:
 
                                                                         
                            All Other
       
                            Option
      Grant
            Estimated Future
  Estimated Future
  Awards:
  Exercise
  Date Fair
            Payouts Under Non-
  Payouts Under
  Number of
  or Base
  Value of
            Equity Incentive
  Equity Incentive
  Securities
  Price of
  Stock and
            Plan Awards(1)   Plan Awards   Underlying
  Option
  Option
    Grant
  Approval
  Target
  Maximum
  Target
  Maximum
  Options
  Awards
  Awards(2)
Name
  Date   Date   ($)   ($)   (#)   (#)   (#)   ($/sh)   ($)
 
Igor Gonda, Ph.D. 
    1/1/2008       1/1/2008       190,000       285,000                                
Nancy Pecota
    9/30/2008       9/22/2008                               225,000       0.39       46,500  
      9/22/2008       9/22/2008       26,700       40,100                                
D. Jeffery Grimes
    7/1/2008       7/1/2008                                       225,000       0.80       95,600  
      1/1/2008       1/1/2008       69,000       103,500                                
Former Executive Officers
                                                                       
Norman Halleen
                                                     
Babatunde A. Otulana, M.D. 
    1/1/2008       1/1/2008       128,800       193,200                                
 
 
(1) Reflects each executive officer’s participation in our 2008 Executive Bonus Plan. The amount of bonus actually earned by each executive officer is reflected in the summary compensation table above.
 
(2) The method of and assumptions used to calculate the value of stock and option awards granted to our named executive officers is discussed in Note 7 of the notes to our financial statements included in our Annual Report on Form 10-K.


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Outstanding Equity Awards At December 31, 2008
 
The following table provides information regarding each unexercised stock equity awards held by each of our named executive officers as of December 31, 2008:
 
                                                         
        Option Awards   Stock Awards
                            Market or
                        Number of
  Payout Value
                        Unearned
  of Unearned
                        Shares, Units
  Shares, Units
                        or Other
  or Other
        Number of Securities
  Option
      Rights That
  Rights That
        Underlying Unexercised Options   Exercise
  Option
  Have Not
  Have Not
        Exercisable
  Unexercisable
  Price(1)
  Expiration
  Vested
  Vested
Name
      (#)   (#)   ($)   Date   (#)   ($)
 
Igor Gonda, Ph.D. 
    (2 )     125,000       375,000       1.60       12/04/2017              
      (3 )                       12/04/2017       300,000       75,000  
      (4 )     291,666       208,334       1.87       08/10/2016              
              4,000             1.52       05/18/2016              
              4,000             5.30       05/19/2015              
              4,000             5.30       05/20/2014              
              2,000             5.30       05/13/2014              
              4,000             6.50       05/15/2013              
              4,000             4.75       02/19/2013              
              2,000             17.25       05/21/2012              
              4,000             17.15       05/17/2012              
              3,000             24.10       02/11/2012              
              500             17.20       09/20/2011              
              1,312             30.00       03/15/2011              
              1,875             107.81       09/22/2000              
              2,624             112.50       02/15/2010              
              1,875             35.00       05/21/2009              
              2,062             60.00       02/02/2009              
Nancy Pecota
    (5 )           225,000       0.39       09/30/2018              
D. Jeffery Grimes
    (2 )     14,062       210,938       0.80       07/01/2018              
      (6 )     11,250       18,750       1.37       06/20/2017              
      (7 )                       10/11/2017       30,000       7,500  
Norman Halleen
                                           
Babatunde A. Otulana, M.D. 
    (2 )     25,000       75,000       1.60       12/04/2017              
      (3 )                       12/04/2017       150,000       37,500  
      (2 )     75,000       125,000       1.37       06/20/2017                  
      (2 )     187,500       112,500       1.70       06/08/2016              
      (6 )     41,250       18,750       3.77       03/07/2016              
      (6 )     23,437       1,563       5.90       02/22/2015              
      (6 )     22,000             12.00       02/27/2014              
              10,000             4.75       02/19/2013              
              26,000             24.10       02/11/2012              
              8,000             17.20       09/20/2011              
              12,000             30.00       03/15/2011              
              8,000             112.50       02/15/2010              
              3,000             35.00       05/21/2009              
              3,000             60.00       02/02/2009              
 
 
(1) Represents the fair market value of a share of our common stock on the grant date of the option.
 
(2) The option vests over four years with 1/16 of the shares of underlying common stock vesting every three months from the grant date.
 
(3) Each restricted stock grant award will vest in full if within three years following the grant of the award if the company achieves certain product and product-pipeline development milestones.


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(4) The option vests over four years with 1/4 of the shares of underlying common stock vesting on the first anniversary of the grant date and 1/48 of the shares of underlying common stock vesting each month thereafter.
 
(5) The option vests over four years with 1/4 of the shares of underlying common stock vesting on September 22, 2009 and 1/16 of the shares of underlying common stock vesting every three months thereafter.
 
(6) The option vests over four years with 1/4 of the shares of underlying common stock vesting on the first anniversary of the grant date and 1/16 of the shares of underlying common stock vesting every three months thereafter.
 
(7) Each restricted stock grant award will vest in full on the second anniversary of the grant date.
 
2008 Option Exercises and Stock Vested
 
None of our named executive officers exercised options or had shares of restricted stock vest in 2008.
 
Pension Benefits
 
None of our named executive officers participate in or have account balances in qualified or non-qualified defined benefit plans sponsored by us. The Committee may elect to adopt qualified or non-qualified defined benefit plans in the future if the Committee determines that doing so is in our best interests.
 
Nonqualified Deferred Compensation
 
None of our named executive officers participate in or have account balances in nonqualified defined contribution plans or other nonqualified deferred compensation plans maintained by us. The Committee may elect to provide our officers and other employees with non-qualified defined contribution or other nonqualified deferred compensation benefits in the future if the Committee determines that doing so is in our best interests.


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Potential Payments Upon Termination or Change in Control
 
The following table and summary set forth potential payments payable to our current executive officers upon termination of employment or a change in control. The Committee may in its discretion revise, amend or add to the benefits if it deems advisable. The table below reflects amounts payable to our executive officers assuming their employment was terminated on December 31, 2008:
 
                             
                Termination
                Without
                Cause or
                Constructive
        Termination Without
      Termination
        Cause Prior to a
  Change in
  Following a Change
        Change in Control
  Control
  in Control
Name
 
Benefit
  ($)   ($)   ($)
 
Igor Gonda, Ph.D. 
  Salary     380,000             760,000  
    Bonus     174,103             348,207  
    Option acceleration(1)                  
    Stock award acceleration(1)           75,000       75,000  
    Benefits continuation     13,471             26,942  
    Career transition assistance                 20,000  
                             
    Total value:     567,574       75,000       1,230,149  
                             
Nancy Pecota
  Salary     238,000             238,000  
    Bonus     87,235             87,235  
    Option acceleration(1)                  
    Stock award acceleration(1)                  
    Benefits continuation     670             670  
    Career transition assistance                 10,000  
                             
    Total value:     325,905             325,905  
                             
D. Jeffery Grimes
  Salary     230,000             230,000  
    Bonus     84,303             84,303  
    Option acceleration(1)                  
    Stock award acceleration(1)                 7,500  
    Benefits continuation     3,810             3,810  
    Career transition assistance                 10,000  
                             
    Total value:     318,113             325,613  
 
 
(1) The value of the stock and option award acceleration was calculated using a value of $0.25 per share of common stock, which was the last reported closing sale price of our common stock on December 31, 2008.
 
Termination without cause prior to a change in control.  If any of our executives is terminated by us without cause prior to a change in control, upon executing a general release and waiver, such executive is entitled to receive (less applicable withholding taxes) in a lump sum payment or in installments, at our discretion:
 
  •  an amount equal to such executive’s annual base salary;
 
  •  an amount equal to such executive’s current target bonus multiplied by the average annual percentage achievement of corporate goals for the three complete fiscal years preceding the termination date; and
 
  •  continuation of such executive’s health insurance benefits for 12 months.
 
Acceleration upon a change in control.  If we undergo a change in control on or prior to December 4, 2010, the restricted stock award granted to Dr. Gonda on December 4, 2007 will vest in full.
 
Termination without cause or constructive termination following a change in control.  If any of our executives is terminated by us without cause or constructively terminated (which includes a material reduction in title or duties, a material reduction in salary or benefits or a relocation of 50 miles or more) during the 18-month


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period following a change in control, upon executing a general release and waiver, such executive is entitled to receive (less applicable withholding taxes):
 
  •  a lump sum payment equal to twice such executive’s annual base salary, in the case of Dr. Gonda, and such executive’s annual base salary, in the case of Ms. Pecota and Mr. Grimes;
 
  •  a lump sum payment equal to such executive’s current target bonus multiplied by (i) twice the average annual percentage achievement of corporate goals for the three complete fiscal years preceding the termination date, in the case of Dr. Gonda, and (ii) the average annual percentage achievement of corporate goals for the three complete fiscal years preceding the termination date, in the case of Ms. Pecota and Mr. Grimes;
 
  •  continuation of such executive’s health insurance benefits for 24 months, in the case of Dr. Gonda, and 12 months, in the case of Ms. Pecota and Mr. Grimes;
 
  •  reimbursement of actual career transition assistance (outplacement services) incurred by such executive within six months of termination in an amount up to $20,000, in the case of Dr. Gonda, and $10,000, in the case of Ms. Pecota and Mr. Grimes; and
 
  •  acceleration of vesting of any stock options or restricted stock awards that remain unvested as of the date of such executive’s termination.
 
Compensation Committee Interlocks and Insider Participation
 
No interlocking relationship exists between our board or the Committee and the board of directors or the compensation committee of any other company, nor has any such interlocking relationship existed in the past.
 
Report of the Compensation Committee
 
The Committee reviewed and discussed with management the Compensation Discussion and Analysis required by Item 402(b) of Regulation S-K, which is contained in this Proxy Statement. Based on this review and discussion, the Committee recommended to the board that the Compensation Discussion and Analysis be included in this Proxy Statement.
 
Members of the Aradigm Corporation
Compensation Committee:
 
Frank H. Barker
John M. Siebert
Virgil D. Thompson, Chairman
 
Non-Employee Director Compensation
 
The following table sets forth a summary of the compensation we paid to our non-employee directors in 2008:
 
                         
    Fees Earned or
    Option
       
    Paid in Cash
    Awards(1)
    Total
 
Name
  ($)     ($)     ($)  
 
Frank H. Barker(2)
    61,000       12,518       73,518  
Stephen O. Jaeger(3)
    18,750       3,747       22,497  
Timothy P. Lynch(4)
    62,000       24,177       86,177  
John M. Siebert(5)
    58,000       12,518       70,518  
Virgil D. Thompson(6)
    99,500       21,908       121,408  
 
 
(1) The method of and assumptions used to calculate the value of the options granted to our directors is discussed in Note 7 of our notes to our financial statements included in our Annual Report on Form 10-K.
 
(2) Mr. Barker owns options to purchase up to 94,043 shares of our common stock as of December 31, 2008, of which 84,043 shares are vested as of December 31, 2008.


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(3) Mr. Jaeger did not stand for re-election to the Board of Directors in May 2008. Mr. Jaeger does not own any options to purchase shares of our common stock as of December 31, 2008.
 
(4) Mr. Lynch owns options to purchase up to 50,000 shares of our common stock as of December 31, 2008, of which 32,500 shares are vested as of December 31, 2008. Mr. Lynch resigned from the Board on February 17, 2009. He will have 90 days from the date of his resignation to exercise any vested options.
 
(5) Dr. Siebert owns options to purchase up to 70,000 shares of our common stock as of December 31, 2008, of which 60,000 shares are vested as of December 31, 2008.
 
(6) Mr. Thompson owns options to purchase up to 156,000 shares of our common stock as of December 31, 2008, of which 138,600 shares are vested as of December 31, 2008.
 
In 2009, the Chairman of the Board will receive an annual retainer of $50,000 and all other non-employee directors will receive an annual cash retainer of $30,000. Board members also receive additional annual retainers for serving on board committees. The additional annual retainer for the Chairman of the Audit Committee will be $15,000 and the additional annual retainer for all other members of the Audit Committee will be $5,000. The additional annual retainer for the Chairman of the Compensation Committee and the Chairman of the Nominating and Corporate Governance Committee will be $10,000 and the additional annual retainer for all other members will be $5,000. The board retainer covers six meetings in a year and, if exceeded, the Chairman of the Board will receive $1,500 for each additional meeting and the other board members will receive $1,000 for each additional meeting. If the number of meetings in a year for any given committee exceeds four, the chairman of the committee will receive $1,500 for each additional meeting and the other committee members will receive $1,000 for each additional meeting. Our directors are also entitled to receive reimbursement of reasonable out-of-pocket expenses incurred by them to attend board meetings.
 
In addition to the cash compensation, each non-employee director will be granted an annual stock option award. Each non-employee director will automatically receive an option to purchase up to 30,000 shares of our common stock upon election to the board. The Chairman of the Board will be granted automatically an option to purchase up to 35,000 shares of our common stock upon re-election to the board and the other members of the board will be granted automatically an option to purchase up to 20,000 shares of our common stock upon re-election to the board.
 
Limitation of Liability of Officers and Directors and Indemnification
 
Our articles of incorporation and bylaws include provisions to (i) eliminate the personal liability of our directors for monetary damages resulting from breaches of their fiduciary duty, to the extent permitted by California law and (ii) permit us to indemnify our directors and officers, employees and other agents to the fullest extent permitted by the California Corporations Code. Pursuant to Section 317 of the California Corporations Code, a corporation generally has the power to indemnify its present and former directors, officers, employees and agents against any expenses incurred by them in connection with any suit to which they are, or are threatened to be made, a party by reason of their serving in such positions so long as they acted in good faith and in a manner they reasonably believed to be in, or not opposed to, the best interests of a corporation and, with respect to any criminal action, they had no reasonable cause to believe their conduct was unlawful. We believe that these provisions are necessary to attract and retain qualified persons as directors and officers. These provisions do not eliminate liability for breach of the directors’ duty of loyalty to us or our shareholders, for acts or omissions not in good faith or involving intentional misconduct or knowing violations of law, for any transaction from which the director derived an improper personal benefit or for any willful or negligent payment of any unlawful dividend.
 
We entered into indemnification agreements with certain officers, including each of our named executive officers, and each of our directors that provide, among other things, that we will indemnify such officer or director, under the circumstances and to the extent provided for therein, for expenses, damages, judgments, fines and settlements such officer or director may be required to pay in actions or proceedings to which such officer or director is or may be made a party by reason of such officer’s or director’s position as an officer, director or other agent of us, and otherwise to the full extent permitted under California law and our bylaws.


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CERTAIN TRANSACTIONS
 
Review, Approval or Ratification of Transactions with Related Persons
 
The Board has adopted, in writing, a policy and procedures for the review of related person transactions. Any related person transaction we propose to enter into must be reported to our Chief Financial Officer or our Vice President of Legal Affairs and, unless otherwise reviewed and approved by the Board, shall be reviewed and approved by the Audit Committee in accordance with the terms of the policy, prior to effectiveness or consummation of any related person transaction, whenever practicable. The policy defines a “related person transaction” as any financial transaction, arrangement or relationship (including any indebtedness or guarantee of indebtedness), or any series of similar transactions, arrangements or relationships in which Aradigm (i) was or is to be a participant, (ii) the amount involved exceeds $120,000 and (iii) a Related Person (as defined therein) had or will have a direct or indirect material interest. In addition, any related person transaction previously approved by the Audit Committee or otherwise already existing that is ongoing in nature shall be reviewed by the Audit Committee annually to ensure that such related person transaction has been conducted in accordance with the previous approval granted by the Audit Committee, if any, and that all required disclosures regarding the related person transaction are made. Transactions involving compensation of executive officers shall be reviewed and approved by the Compensation Committee in the manner specified in the charter of the Compensation Committee. As appropriate for the circumstances, the Audit Committee shall review and consider the Related Person’s interest in the related person transaction, the approximate dollar value of the amount involved in the related person transaction, the approximate dollar value of the amount of the Related Person’s interest in the transaction without regard to the amount of any profit or loss, whether the transaction was undertaken in the ordinary course of business, whether the transaction with the Related Person is proposed to be, or was, entered into on terms no less favorable to the company than terms that could have been reached with an unrelated third party, the purpose of, and the potential benefits to us of the transaction and any other information regarding the related person transaction or the Related Person in the context of the proposed transaction that would be material to investors in light of the circumstances of the particular transaction.
 
HOUSEHOLDING OF PROXY MATERIALS
 
The SEC has adopted rules that permit companies and intermediaries (e.g., brokers) to satisfy the delivery requirements for proxy statements and annual reports with respect to two or more shareholders sharing the same address by delivering a single proxy statement addressed to those shareholders. This process, which is commonly referred to as “householding, “potentially means extra convenience for shareholders and cost savings for companies.
 
This year, a number of brokers with account holders who are our shareholders will be “householding” our proxy materials. A single proxy statement will be delivered to multiple shareholders sharing an address unless contrary instructions have been received from the affected shareholders. Once you have received notice from your broker that they will be “householding” communications to your address, “householding “will continue until you are notified otherwise or until you revoke your consent. If, at any time, you no longer wish to participate in “householding” and would prefer to receive a separate proxy statement and annual report, please notify your broker, direct your written request to Aradigm Corporation, Secretary, 3929 Point Eden Way, Hayward, CA 94545 or contact our Secretary at (510) 265-9000. Shareholders who currently receive multiple copies of the proxy statement at their address and would like to request “householding “of their communications should contact their broker.


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OTHER MATTERS
 
The Board of Directors knows of no other matters that will be presented for consideration at the annual meeting. If any other matters are properly brought before the meeting, it is the intention of the persons named in the accompanying proxy to vote on such matters in accordance with their best judgment.
 
By Order of the Board of Directors
 
-s- IGOR GONDA
Igor Gonda, Ph.D.
President and Chief Executive Officer
 
April 9, 2009
 
A copy of our Annual Report on Form 10-K for the fiscal year ended December 31, 2008 is available without charge upon written request to: Secretary, Aradigm Corporation, 3929 Point Eden Way, Hayward, CA 94545. Copies may also be obtained without charge through the SEC’s website at http://www.sec.gov.


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Appendix A
 
ARADIGM CORPORATION
 
Employee Stock Purchase Plan
 
Adopted April 16, 1996
Approved by the Shareholders on June 5, 1996
Amended by the Board of Directors on April 7, 1998
Approved by the Shareholders on May 15, 1998
Amended by the Board of Directors on February 2, 1999
Approved by the Shareholders on May 21, 1999
Amended by the Board of Directors on April 3, 2000
Approved by the Shareholders on May 19, 2000
Amended by the Board of Directors on April 2, 2001
Approved by the Shareholders on May 18, 2001
Amended by the Board of Directors on December 17, 2001
Approved by the Shareholders on February 8, 2002
Amended by the Board of Directors on February 19, 2003
Approved by the Shareholders on May 15, 2003
Amended by the Board of Directors on March 21, 2005
Approved by the Shareholders on May 19, 2005
Amended by the Board of Directors on April 4, 2008
Approved by the Shareholders on May 15, 2008
Amended by the Board of Directors on February 25, 2009
 
Purpose
 
The purpose of the Employee Stock Purchase Plan (the “Plan”) is to provide a means by which employees of Aradigm Corporation, a California corporation (the “Company”), and its Affiliates, as defined in subparagraph 1(b), which are designated as provided in subparagraph 2(b), may be given an opportunity to purchase stock of the Company.
 
The word “Affiliate” as used in the Plan means any parent corporation or subsidiary corporation of the Company, as those terms are defined in Sections 424(e) and (f), respectively, of the Internal Revenue Code of 1986, as amended (the “Code”).
 
The Company, by means of the Plan, seeks to retain the services of its employees, to secure and retain the services of new employees, and to provide incentives for such persons to exert maximum efforts for the success of the Company.
 
The Company intends that the rights to purchase stock of the Company granted under the Plan be considered options issued under an “employee stock purchase plan” as that term is defined in Section 423(b) of the Code.
 
Administration
 
The Plan shall be administered by the Board of Directors (the “Board”) of the Company unless and until the Board delegates administration to a Committee, as provided in subparagraph 2(c). Whether or not the Board has delegated administration, the Board shall have the final power to determine all questions of policy and expediency that may arise in the administration of the Plan.


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The Board shall have the power, subject to, and within the limitations of, the express provisions of the Plan:
 
To determine when and how rights to purchase stock of the Company shall be granted and the provisions of each offering of such rights (which need not be identical).
 
To designate from time to time which Affiliates of the Company shall be eligible to participate in the Plan.
 
To construe and interpret the Plan and rights granted under it, and to establish, amend and revoke rules and regulations for its administration. The Board, in the exercise of this power, may correct any defect, omission or inconsistency in the Plan, in a manner and to the extent it shall deem necessary or expedient to make the Plan fully effective.
 
To amend the Plan as provided in paragraph 13.
 
Generally, to exercise such powers and to perform such acts as the Board deems necessary or expedient to promote the best interests of the Company and its Affiliates and to carry out the intent that the Plan be treated as an “employee stock purchase plan” within the meaning of Section 423 of the Code.
 
The Board may delegate administration of the Plan to a Committee composed of not fewer than two (2) members of the Board (the “Committee”) constituted in accordance with the requirements of Rule 16b-3 under the Exchange Act. If administration is delegated to a Committee, the Committee shall have, in connection with the administration of the Plan, the powers theretofore possessed by the Board, subject, however, to such resolutions, not inconsistent with the provisions of the Plan, as may be adopted from time to time by the Board. The Board may abolish the Committee at any time and revest in the Board the administration of the Plan.
 
Shares Subject to the Plan
 
Subject to the provisions of paragraph 12 relating to adjustments upon changes in stock, the stock that may be sold pursuant to rights granted under the Plan shall not exceed in the aggregate four million five hundred fifty thousand (4,550,000) shares of the Company’s common stock (the “Common Stock”). If any right granted under the Plan shall for any reason terminate without having been exercised, the Common Stock not purchased under such right shall again become available for the Plan.
 
The stock subject to the Plan may be unissued shares or reacquired shares, bought on the market or otherwise.
 
Grant of Rights; Offering
 
The Board or the Committee may from time to time grant or provide for the grant of rights to purchase Common Stock of the Company under the Plan to eligible employees (an “Offering”) on a date or dates (the “Offering Date(s)”) selected by the Board or the Committee. Each Offering shall be in such form and shall contain such terms and conditions as the Board or the Committee shall deem appropriate, which shall comply with the requirements of Section 423(b)(5) of the Code that all employees granted rights to purchase stock under the Plan shall have the same rights and privileges. The terms and conditions of an Offering shall be incorporated by reference into the Plan and treated as part of the Plan. The provisions of separate Offerings need not be identical, but each Offering shall include (through incorporation of the provisions of this Plan by reference in the document comprising the Offering or otherwise) the period during which the Offering shall be effective, which period shall not exceed twenty-seven (27) months beginning with the Offering Date, and the substance of the provisions contained in paragraphs 5 through 8, inclusive.
 
Eligibility
 
Rights may be granted only to employees of the Company or, as the Board or the Committee may designate as provided in subparagraph 2(b), to employees of any Affiliate of the Company. Except as provided in subparagraph 5(b), an employee of the Company or any Affiliate shall not be eligible to be granted rights under the Plan, unless, on the Offering Date, such employee has been in the employ of the Company or any Affiliate for such continuous period preceding such grant as the Board or the Committee may require, but in no event shall the required period of continuous employment be equal to or greater than two (2) years. In addition, unless otherwise determined by the Board or the Committee and set forth in the terms of the applicable Offering, no employee of the Company or any


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Affiliate shall be eligible to be granted rights under the Plan, unless, on the Offering Date, such employee’s customary employment with the Company or such Affiliate is for at least twenty (20) hours per week and at least five (5) months per calendar year.
 
The Board or the Committee may provide that, each person who, during the course of an Offering, first becomes an eligible employee of the Company or designated Affiliate will, on a date or dates specified in the Offering which coincides with the day on which such person becomes an eligible employee or occurs thereafter, receive a right under that Offering, which right shall thereafter be deemed to be a part of that Offering. Such right shall have the same characteristics as any rights originally granted under that Offering, as described herein, except that:
 
the date on which such right is granted shall be the “Offering Date” of such right for all purposes, including determination of the exercise price of such right;
 
the period of the Offering with respect to such right shall begin on its Offering Date and end coincident with the end of such Offering; and
 
the Board or the Committee may provide that if such person first becomes an eligible employee within a specified period of time before the end of the Offering, he or she will not receive any right under that Offering.
 
No employee shall be eligible for the grant of any rights under the Plan if, immediately after any such rights are granted, such employee owns stock possessing five percent (5%) or more of the total combined voting power or value of all classes of stock of the Company or of any Affiliate. For purposes of this subparagraph 5(c), the rules of Section 424(d) of the Code shall apply in determining the stock ownership of any employee, and stock which such employee may purchase under all outstanding rights and options shall be treated as stock owned by such employee.
 
An eligible employee may be granted rights under the Plan only if such rights, together with any other rights granted under “employee stock purchase plans” of the Company and any Affiliates, as specified by Section 423(b)(8) of the Code, do not permit such employee’s rights to purchase stock of the Company or any Affiliate to accrue at a rate which exceeds twenty five thousand dollars ($25,000) of fair market value of such stock (determined at the time such rights are granted) for each calendar year in which such rights are outstanding at any time.
 
Officers of the Company and any designated Affiliate shall be eligible to participate in Offerings under the Plan, provided, however, that the Board may provide in an Offering that certain employees who are highly compensated employees within the meaning of Section 423(b)(4)(D) of the Code shall not be eligible to participate.
 
Rights; Purchase Price
 
On each Offering Date, each eligible employee, pursuant to an Offering made under the Plan, shall be granted the right to purchase up to the number of shares of Common Stock of the Company purchasable with a percentage designated by the Board or the Committee not exceeding fifteen percent (15%) of such employee’s Earnings (as defined by the Board or the Committee in each Offering) during the period which begins on the Offering Date (or such later date as the Board or the Committee determines for a particular Offering) and ends on the date stated in the Offering, which date shall be no later than the end of the Offering. The Board or the Committee shall establish one or more dates during an Offering (the “Purchase Date(s)”) on which rights granted under the Plan shall be exercised and purchases of Common Stock carried out in accordance with such Offering.
 
In connection with each Offering made under the Plan, the Board or the Committee may specify a maximum number of shares that may be purchased by any employee as well as a maximum aggregate number of shares that may be purchased by all eligible employees pursuant to such Offering. In addition, in connection with each Offering that contains more than one Purchase Date, the Board or the Committee may specify a maximum aggregate number of shares which may be purchased by all eligible employees on any given Purchase Date under the Offering. If the aggregate purchase of shares upon exercise of rights granted under the Offering would exceed any such maximum


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aggregate number, the Board or the Committee shall make a pro rata allocation of the shares available in as nearly a uniform manner as shall be practicable and as it shall deem to be equitable.
 
The purchase price of stock acquired pursuant to rights granted under the Plan shall be not less than the lesser of:
 
an amount equal to eighty-five percent (85%) of the fair market value of the stock on the Offering Date; or
 
an amount equal to eighty-five percent (85%) of the fair market value of the stock on the Purchase Date.
 
Participation; Withdrawal; Termination
 
An eligible employee may become a participant in the Plan pursuant to an Offering by delivering a participation agreement to the Company within the time specified in the Offering, in such form as the Company provides. Each such agreement shall authorize payroll deductions of up to the maximum percentage specified by the Board or the Committee of such employee’s Earnings during the Offering (as defined by the Board or Committee in each Offering). The payroll deductions made for each participant shall be credited to an account for such participant under the Plan and shall be deposited with the general funds of the Company. A participant may reduce (including to zero) or increase such payroll deductions, and an eligible employee may begin such payroll deductions, after the beginning of any Offering only as provided for in the Offering. A participant may make additional payments into his or her account only if specifically provided for in the Offering and only if the participant has not had the maximum amount withheld during the Offering.
 
At any time during an Offering, a participant may terminate his or her payroll deductions under the Plan and withdraw from the Offering by delivering to the Company a notice of withdrawal in such form as the Company provides. Such withdrawal may be elected at any time prior to the end of the Offering except as provided by the Board or the Committee in the Offering. Upon such withdrawal from the Offering by a participant, the Company shall distribute to such participant all of his or her accumulated payroll deductions (reduced to the extent, if any, such deductions have been used to acquire stock for the participant) under the Offering, without interest, and such participant’s interest in that Offering shall be automatically terminated. A participant’s withdrawal from an Offering will have no effect upon such participant’s eligibility to participate in any other Offerings under the Plan but such participant will be required to deliver a new participation agreement in order to participate in subsequent Offerings under the Plan.
 
Rights granted pursuant to any Offering under the Plan shall terminate immediately upon cessation of any participating employee’s employment with the Company and any designated Affiliate, for any reason, and the Company shall distribute to such terminated employee all of his or her accumulated payroll deductions (reduced to the extent, if any, such deductions have been used to acquire stock for the terminated employee) under the Offering, without interest.
 
Rights granted under the Plan shall not be transferable by a participant otherwise than by will or the laws of descent and distribution, or by a beneficiary designation as provided in paragraph 14 and, otherwise during his or her lifetime, shall be exercisable only by the person to whom such rights are granted.
 
Exercise
 
On each Purchase Date specified therefor in the relevant Offering, each participant’s accumulated payroll deductions and other additional payments specifically provided for in the Offering (without any increase for interest) will be applied to the purchase of whole shares of stock of the Company, up to the maximum number of shares permitted pursuant to the terms of the Plan and the applicable Offering, at the purchase price specified in the Offering. No fractional shares shall be issued upon the exercise of rights granted under the Plan. The amount, if any, of accumulated payroll deductions remaining in each participant’s account after the purchase of shares which is less than the amount required to purchase one share of stock on the final Purchase Date of an Offering shall be held in each such participant’s account for the purchase of shares under the next Offering under the Plan, unless such participant withdraws from such next Offering, as provided in subparagraph 7(b), or is no longer eligible to be granted rights under the Plan, as provided in paragraph 5, in which case such amount shall be distributed to the participant after such final Purchase Date, without interest. The amount, if any, of accumulated payroll deductions


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remaining in any participant’s account after the purchase of shares which is equal to the amount required to purchase whole shares of stock on the final Purchase Date of an Offering shall be distributed in full to the participant after such Purchase Date, without interest.
 
No rights granted under the Plan may be exercised to any extent unless the shares to be issued upon such exercise under the Plan (including rights granted thereunder) are covered by an effective registration statement pursuant to the Securities Act of 1933, as amended (the “Securities Act”) and the Plan is in material compliance with all applicable state, foreign and other securities and other laws applicable to the Plan. If on a Purchase Date in any Offering hereunder the Plan is not so registered or in such compliance, no rights granted under the Plan or any Offering shall be exercised on such Purchase Date, and the Purchase Date shall be delayed until the Plan is subject to such an effective registration statement and such compliance, except that the Purchase Date shall not be delayed more than twelve (12) months and the Purchase Date shall in no event be more than twenty-seven (27) months from the Offering Date. If on the Purchase Date of any Offering hereunder, as delayed to the maximum extent permissible, the Plan is not registered and in such compliance, no rights granted under the Plan or any Offering shall be exercised and all payroll deductions accumulated during the Offering (reduced to the extent, if any, such deductions have been used to acquire stock) shall be distributed to the participants, without interest.
 
Covenants of the Company
 
During the terms of the rights granted under the Plan, the Company shall keep available at all times the number of shares of stock required to satisfy such rights.
 
The Company shall seek to obtain from each federal, state, foreign or other regulatory commission or agency having jurisdiction over the Plan such authority as may be required to issue and sell shares of stock upon exercise of the rights granted under the Plan. If, after reasonable efforts, the Company is unable to obtain from any such regulatory commission or agency the authority which counsel for the Company deems necessary for the lawful issuance and sale of stock under the Plan, the Company shall be relieved from any liability for failure to issue and sell stock upon exercise of such rights unless and until such authority is obtained.
 
Use of Proceeds from Stock
 
Proceeds from the sale of stock pursuant to rights granted under the Plan shall constitute general funds of the Company.
 
Rights as a Shareholder
 
A participant shall not be deemed to be the holder of, or to have any of the rights of a holder with respect to, any shares subject to rights granted under the Plan unless and until the participant’s shareholdings acquired upon exercise of rights under the Plan are recorded in the books of the Company.
 
Adjustments upon Changes in Stock
 
If any change is made in the stock subject to the Plan, or subject to any rights granted under the Plan (through merger, consolidation, reorganization, recapitalization, reincorporation, stock dividend, dividend in property other than cash, stock split, liquidating dividend, combination of shares, exchange of shares, change in corporate structure or other transaction not involving the receipt of consideration by the Company), the Plan and outstanding rights will be appropriately adjusted in the class(es) and maximum number of shares subject to the Plan and the class(es) and number of shares and price per share of stock subject to outstanding rights. Such adjustments shall be made by the Board or the Committee, the determination of which shall be final, binding and conclusive. (The conversion of any convertible securities of the Company shall not be treated as a “transaction not involving the receipt of consideration by the Company.”)
 
In the event of: (1) a dissolution or liquidation of the Company; (2) a merger or consolidation in which the Company is not the surviving corporation; (3) a reverse merger in which the Company is the surviving corporation but the shares of the Company’s Common Stock outstanding immediately preceding the merger are converted by virtue of the merger into other property, whether in the form of securities, cash or otherwise; or (4) the acquisition by


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any person, entity or group within the meaning of Section 13(d) or 14(d) of the Exchange Act or any comparable successor provisions (excluding any employee benefit plan, or related trust, sponsored or maintained by the Company or any Affiliate of the Company) of the beneficial ownership (within the meaning of Rule 13d-3 promulgated under the Exchange Act, or comparable successor rule) of securities of the Company representing at least fifty percent (50%) of the combined voting power entitled to vote in the election of directors, then, as determined by the Board in its sole discretion (i) any surviving or acquiring corporation may assume outstanding rights or substitute similar rights for those under the Plan, (ii) such rights may continue in full force and effect, or (iii) participants’ accumulated payroll deductions may be used to purchase Common Stock immediately prior to the transaction described above and the participants’ rights under the ongoing Offering terminated.
 
Amendment of the Plan
 
The Board at any time, and from time to time, may amend the Plan. However, except as provided in paragraph 12 relating to adjustments upon changes in stock, no amendment shall be effective unless approved by the shareholders of the Company within twelve (12) months before or after the adoption of the amendment, where the amendment will:
 
Increase the number of shares reserved for rights under the Plan;
 
Modify the provisions as to eligibility for participation in the Plan (to the extent such modification requires shareholder approval in order for the Plan to obtain employee stock purchase plan treatment under Section 423 of the Code or to comply with the requirements of Rule 16b-3 promulgated under the Exchange Act as amended (“Rule 16b-3”)); or employee stock purchase plan treatment under Section 423 of the Code or to comply with the requirements of Rule 16b-3 promulgated under the Exchange Act as amended (“Rule 16b-3”)); or
 
Modify the Plan in any other way if such modification requires shareholder approval in order for the Plan to obtain employee stock purchase plan treatment under Section 423 of the Code or to comply with the requirements of Rule 16b-3.
 
It is expressly contemplated that the Board may amend the Plan in any respect the Board deems necessary or advisable to provide eligible employees with the maximum benefits provided or to be provided under the provisions of the Code and the regulations promulgated thereunder relating to employee stock purchase plans and/or to bring the Plan and/or rights granted under it into compliance therewith.
 
Rights and obligations under any rights granted before amendment of the Plan shall not be impaired by any amendment of the Plan, except with the consent of the person to whom such rights were granted, or except as necessary to comply with any laws or governmental regulations, or except as necessary to ensure that the Plan and/or rights granted under the Plan comply with the requirements of Section 423 of the Code.
 
Designation of Beneficiary
 
A participant may file a written designation of a beneficiary who is to receive any shares and cash, if any, from the participant’s account under the Plan in the event of such participant’s death subsequent to the end of an Offering but prior to delivery to the participant of such shares and cash. In addition, a participant may file a written designation of a beneficiary who is to receive any cash from the participant’s account under the Plan in the event of such participant’s death during an Offering.
 
Such designation of beneficiary may be changed by the participant at any time by written notice. In the event of the death of a participant and in the absence of a beneficiary validly designated under the Plan who is living at the time of such participant’s death, the Company shall deliver such shares and/or cash to the executor or administrator of the estate of the participant, or if no such executor or administrator has been appointed (to the knowledge of the Company), the Company, in its sole discretion, may deliver such shares and/or cash to the spouse or to any one or


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more dependents or relatives of the participant, or if no spouse, dependent or relative is known to the Company, then to such other person as the Company may designate.
 
Termination or Suspension of the Plan
 
The Board in its discretion, may suspend or terminate the Plan at any time. No rights may be granted under the Plan while the Plan is suspended or after it is terminated.
 
Rights and obligations under any rights granted while the Plan is in effect shall not be impaired by suspension or termination of the Plan, except as expressly provided in the Plan or with the consent of the person to whom such rights were granted, or except as necessary to comply with any laws or governmental regulation, or except as necessary to ensure that the Plan and/or rights granted under the Plan comply with the requirements of Section 423 of the Code.
 
Effective Date of Plan
 
The Plan shall become effective on the same day that the Company’s initial public offering of shares of common stock becomes effective (the “Effective Date”), but no rights granted under the Plan shall be exercised unless and until the Plan has been approved by the shareholders of the Company within twelve (12) months before or after the date the Plan is adopted by the Board or the Committee, which date may be prior to the Effective Date.


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PROXY
ARADIGM CORPORATION
PROXY SOLICITED BY THE BOARD OF DIRECTORS
FOR THE ANNUAL MEETING OF SHAREHOLDERS
TO BE HELD ON MAY 15, 2009
     The undersigned hereby appoints IGOR GONDA and D. JEFFERY GRIMES, and each of them, as attorneys and proxies of the undersigned, with full power of substitution, to vote all shares of stock of Aradigm Corporation that the undersigned may be entitled to vote at the 2009 Annual Meeting of Shareholders of Aradigm Corporation to be held at Aradigm Corporation’s offices located at 3929 Point Eden Way, Hayward, California on Friday, May 15, 2009 at 9:00 a.m. local time, and at any and all postponements, continuations and adjournments thereof, with all powers that the undersigned would possess if personally present, upon and in respect of the following matters and in accordance with the following instructions, with discretionary authority as to any and all other matters that may properly come before the meeting.
     þ Please mark votes as in this example.
     MANAGEMENT RECOMMENDS A VOTE FOR THE NOMINEES FOR DIRECTOR LISTED BELOW AND A VOTE “FOR” PROPOSALS 2 AND 3
     UNLESS A CONTRARY DIRECTION IS INDICATED, THIS PROXY WILL BE VOTED FOR ALL NOMINEES LISTED IN PROPOSAL 1 AND FOR PROPOSALS 2 AND 3, AS MORE SPECIFICALLY DESCRIBED IN THE PROXY STATEMENT. IF SPECIFIC INSTRUCTIONS ARE INDICATED, THIS PROXY WILL BE VOTED IN ACCORDANCE THEREWITH.
             
1.
  To elect (01) Frank H. Barker, (02) Igor Gonda, (03) John M. Siebert and (04) Virgil D. Thompson as directors to hold office until the next annual meeting of shareholders and until their successors are elected.   FOR ALL NOMINEES
WITHHELD FROM ALL NOMINEES
FOR ALL NOMINEES EXCEPT:                     
  o
o
o
                 
2.
  To approve an amendment to the Aradigm Corporation Employee Stock Purchase Plan to increase the aggregate number of shares of Common Stock authorized for issuance under such plan by 2.500,000 shares.   FOR
o
  AGAINST
o
  ABSTAIN
o
 
               
3.
  To ratify the selection of Odenberg, Ullakko, Muranishi & Co. LLP as Aradigm’s independent registered public accounting firm for the fiscal year ending December 31, 2009.   FOR
o
  AGAINST
o
  ABSTAIN
o
     Please vote, date and promptly return this proxy in the enclosed return envelope which is postage prepaid if mailed in the United States.
     Please sign exactly as your name appears hereon. If stock is registered in the names of two or more persons, each should sign. Executors, administrators, trustees, guardians and attorneys-in-fact should add their titles. If signer is a corporation, please give full corporate name and have a duly authorized officer sign. If signer is a partnership, please sign in partnership name and by authorized person.
                     
Signature:
          Date:        
 
                   
 
                   
Signature:
          Date: