UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* INTRABIOTICS PHARMACEUTICALS, INC. ---------------------------------- (Name of Issuer) COMMON STOCK, PAR VALUE $.001 PER SHARE --------------------------------------- (Title of Class of Securities) 46116T100 --------- (CUSIP Number) DECEMBER 31, 2003 ----------------- (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is filed: [_] Rule 13d-1(b) [X] Rule 13d-1(c) [_] Rule 13d-1(d) *The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page. The information required on the reminder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes). CUSIP NO. 46116T100 Schedule 13G Page 2 of 7 -------------------------------------------------------------------------------- 1. Name of Reporting Person S.S. or I.R.S. Identifica- tion No. of Above Person Frank H. Pearl (in the capacity described herein) -------------------------------------------------------------------------------- 2. Check the Appropriate Box (a) [_] if a Member of a Group (b) [X] -------------------------------------------------------------------------------- 3. S.E.C. Use Only -------------------------------------------------------------------------------- 4. Citizenship or Place of Organization United States -------------------------------------------------------------------------------- Number of Shares (5) Sole Voting Power 0 Beneficially (6) Shared Voting Power 97,133 Owned by Each (7) Sole Dispositive Power 0 Reporting Person (8) Shared Dispositive Power 97,133 -------------------------------------------------------------------------------- 9. Aggregate Amount Beneficially Owned by Each Reporting Person 97,133 -------------------------------------------------------------------------------- 10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares [_] -------------------------------------------------------------------------------- 11. Percent of Class Represented by Amount in Row 9 1.8% -------------------------------------------------------------------------------- 12. Type of Reporting Person IN -------------------------------------------------------------------------------- CUSIP NO. 46116T100 Schedule 13G Page 3 of 7 Item 1. (a) NAME OF ISSUER IntraBiotics Pharmaceuticals, Inc. (the "Company"). (b) ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES 1245 Terra Bella Avenue Mountain View, CA 94043 Item 2. (a) NAMES OF PERSONS FILING Mr. Frank H. Pearl ("Mr. Pearl") (b) ADDRESS OF PRINCIPAL BUSINESS OFFICE The address of the principal business offices of Mr. Pearl is 2099 Pennsylvania Avenue, Suite 900, Washington, DC 20006-1813. (c) CITIZENSHIP United States (d) TITLE OF CLASS OF SECURITIES Common Stock, par value $.001 per share (the "Common Stock" or "Shares") (e) CUSIP NUMBER 46116T100 Item 3. This statement is not filed pursuant to either Rule 13d-1(b) or 13d-2(b) or (c). Item 4. OWNERSHIP. (a) AMOUNT BENEFICIALLY OWNED: Mr. Pearl may be deemed to beneficially own an aggregate of 97,133 shares of Common Stock. Mr. Pearl is the sole owner of Perseuspur, LLC, a member of Perseus EC, LLC, which is the managing member of Perseus BioTech Fund Partners, LLC, a managing member of Perseus-Soros Partners, LLC, the general partner of Perseus-Soros BioPharmaceutical Fund, L.P. ("PSBF"), and may be deemed to beneficially own the 97,133 shares of Common Stock owned by PSBF. CUSIP NO. 46116T100 Schedule 13G Page 4 of 7 (b) PERCENTAGE OWNED: Based on calculations made in accordance with Rule 13d-3(d), and there being 5,253,983 shares of Common Stock outstanding as of this date, Mr. Pearl may be deemed to beneficially own approximately 1.8% of the outstanding shares of Common Stock. (c) NUMBER OF SHARES AS TO WHICH SUCH PERSON HAS: Mr. Pearl may be deemed to share the power to direct the voting and disposition of the 97,133 Common Stock beneficially owned by PSBP. Item 5. OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following. [X] Item 6. OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON Not applicable. Item 7. IDENTIFICATION AND CLASSIFICATION OF SUBSIDIARY WHICH ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY Not applicable. Item 8. IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP Not applicable. Item 9. NOTICE OF DISSOLUTION OF GROUP Not applicable. Item 10. CERTIFICATION By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect. [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK] CUSIP NO. 46116T100 Schedule 13G Page 5 of 7 SIGNATURES After reasonable inquiry and to the best of our knowledge and belief, the undersigned certifies that the information set forth in this statement is true, complete and correct. Dated as of February 17, 2004 FRANK H. PEARL By: /s/ Rodd Macklin --------------------------------------- Name: Rodd Macklin Title: Attorney-in-Fact CUSIP NO. 46116T100 Schedule 13G Page 6 of 7 EXHIBIT INDEX Exhibit 1. Power of Attorney, dated April 9, 2003, appointing Rodd Macklin as Attorney-in-Fact for Frank H. Pearl.