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Foundation Medicine to Share 14 Abstracts at the 2022 European Society for Medical Oncology (ESMO) Congress Demonstrating the Power of Genomic Profiling to Advance Cancer Care

Data further reinforces the value of Foundation Medicine’s proprietary homologous recombination deficiency (HRD) signature

Foundation Medicine, Inc., a pioneer in molecular profiling for cancer, today announced that the company and its collaborators will present 14 abstracts at the 2022 European Society for Medical Oncology Congress being held virtually and in person in Paris from September 9-13, 2022.

Highlights from the presentations include:

  • Two studies leveraging Foundation Medicine’s novel homologous recombination deficiency signature (HRDsig) to explore whether this biomarker is associated with FOLFIRINOX benefit in patients with metastatic pancreatic cancer via the Flatiron Health-Foundation Medicine Clinico-Genomic Database (CGDB), and to understand the prevalence of HRDsig positivity in non-small cell lung cancer using FoundationOne®CDx.



  • A real-world analysis of 447 men in the CGDB with de novo metastatic prostate cancer treated in standard of care settings, found that the subgroup with SPOP mutations had much more favorable time to castration resistance and overall survival if treated with second generation hormonal agents versus docetaxel. Another study using Foundation Medicine’s tissue-based comprehensive genomic profiling (CGP) test found that SPOP mutations occur in a moderate number of Clinically Advanced Prostate Cancer (CAPC) cases and are associated with lower frequencies of TMPRSS2: ERG fusions, AR amplifications, cell cycle genomic alterations (GA) and MTOR pathway GA and higher frequencies of immunotherapy drug efficacy biomarkers including microsatellite instability-high (MSI-H), tumor mutational burden high (TMB-H) and PD-L1 status.



  • A large-scale analysis of lung cancer cases, sequenced using FoundationOne CDx, to identify genomic alterations associated with loco-regional lesions, extracranial metastases and brain metastases to determine their functional roles and downstream pathways, providing a foundation for the development of RICTOR-targeted therapeutic strategies for the treatment and/or prevention of lung cancer brain metastases.

  • A characterization of the genomic landscapes of TMB-H versus TMB-low (TMB-L) in patients with intrahepatic cholangiocarcinomas (iCCA) using FoundationOne CDx. Findings support the clinical development of immunotherapy approaches for the treatment of TMB-H iCCA patients.

“This data demonstrates the power of our tissue- and liquid-based comprehensive genomic profiling tests for enabling critical research on complex genomic signatures and emerging biomarkers,” said Priti Hegde, PhD, Chief Scientific Officer at Foundation Medicine. “We’re proud to be working across the cancer research community to deepen our collective understanding of cancer biology and ultimately support better care for patients in the future.”

The following is a list of abstracts that will be presented at the meeting. To access all abstracts being presented at ESMO, please visit: https://oncologypro.esmo.org/meeting-resources/esmo-congress

Follow Foundation Medicine on Twitter and LinkedIn for more updates from #ESMO22 and visit us in person at booth #306.

Abstract #

Title

Product*

Collaborators

Proffered Paper Session

 

Sunday, September 11, 2022,

4:40 - 4:50 PM CET

 

#1696O

 

Genomic profiling and molecular targeting of lung cancer brain metastases



FoundationOne CDx

 

Montefiore Einstein Cancer Center

Mini Oral Sessions

 

Saturday, September 10, 2022,

11:15 - 11:20 AM CET

 

#660MO

 

Molecular targets in salivary gland cancers: A comprehensive genomic analysis of 1,666 cases

FoundationOne CDx

 

Upstate Medical University

 

Monday, September 12, 2022,

3:35 - 3:40 PM CET

 

#1487MO

 

A pan-sarcoma investigation of genetic alterations associated with high telomeric content

FoundationOne Heme

Omico (Australian genomic Cancer Medicine), Garvan Institute of Medical Research; St Vincent’s Clinical School, University of New South Wales, Australia

Posters



Saturday, September 10, 2022

 

#97P

 

 

 

 

Pan-cancer landscape of clonal tumor mutational burden (cTMB)

 

 

FoundationOne CDx

 

Massachusetts General Cancer Center, MA, USA; Harvard Medical School, MA, USA; Georgia Institute of Technology, GA, USA; Massachusetts General Hospital, MA, US



Saturday, September 10, 2022

 

#100P

 

 

 

Co-mutational landscape of key fibroblast growth factor receptor (FGFR) alterations in intra-hepatic cholangiocarcinoma (iCCA), bladder cancer (BC) and glioma

FoundationOne CDx

 

Ospedale San Raffaele,

Vita-Salute San Raffaele University, Milan, Italy; Tyra Biosciences, Carlsbad, CA, USA; F. Hoffmann-La Roche Ltd, Basel, Switzerland; Jefferson Health, Philadelphia, PA, USA; Ohio State University, Columbus, OH, USA; Repare Therapeutics, Cambridge, MA, USA; Hannover Medical School, Hannover, Germany



Sunday, September 11, 2022

 

#1373P

 

SPOP mutations (mtSPOP) are a treatment-selection biomarker in patients (pts) with de novo metastatic castration-sensitive prostate cancer (dn-mCSPC).

Clinico-Genomic Database (CGDB)

 

Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah; University of Minnesota Masonic Cancer Center, Minneapolis, MN



Sunday, September 11, 2022

 

#1393P

 

Comparison of genomic alterations (GA) landscape in SPOP mutated (SPOPmut) and SPOP wild type (SPOPwt) clinically advanced prostate cancer (CAPC)

FoundationOne CDx

 

Ospedale San Raffaele,

Vita-Salute San Raffaele University, Milan, Italy/Moffitt Cancer Center/SUNY Upstate Medical University

Sunday, September 11, 2022



#1368P



TALAPRO-1: Talazoparib monotherapy in metastatic castration-resistant prostate cancer (mCRPC) with DNA damage response alterations (DDRm)—Exploration of tumor genetics associated with prolonged benefit



 

FoundationOne CDx

 

The Institute of Cancer Research and The Royal Marsden Hospital, London, UK; various other institutions; Pfizer

 



Sunday, September 11, 2022

 

#1521P

 

Comprehensive genomic profiling (CGP) of epithelioid hemangioendothelioma (EHE) and liver angiosarcomas (LAS)

FoundationOne CDx

 

Medical College of Wisconsin

 

 

Sunday, September 11, 2022

 

#1710P

 

Genomic landscape (GL) with potential of methylthioadenosine phosphorylase (MTAP) loss in clinically advanced breast cancer (CABC)

 

FoundationOne CDx

Upstate Medical University



Monday, September 12, 2022

 

#1046P

 

Homologous recombination deficiency (HRD) and genomic associations in non-small cell lung cancer (NSCLC) using a novel HRD signature (HRDsig)

FoundationOne CDx

 

UC Davis Health



Monday, September 12, 2022

 

#1300P

 

 

Exploration of a novel HRD signature (HRDsig) as a biomarker of first line FOLFIRINOX benefit in metastatic pancreatic cancer

Clinico-Genomic Database (CGDB)

UPMC Hillman Cancer Center, Pittsburgh, PA

 



Monday, September 12, 2022

 

#63P

 

Intrahepatic cholangiocarcinoma (iCCA) genomic findings with high versus low tumor mutational burdens

FoundationOne CDx

 

University of Texas MD Anderson Cancer Center

Monday, September 12, 2022

 

#1778P

Comparative genomic alterations (GA) landscape in urothelial carcinoma of the bladder (UCB) in patients of South Asian ancestry (SAS)

FoundationOne CDx

Ospedale San Raffaele,

Vita-Salute San Raffaele University, Milan, Italy; Moffitt Cancer Center

*May include previous versions of Foundation Medicine’s assays

About Foundation Medicine: Your Essential Partner in Cancer Care

Foundation Medicine is a pioneer in molecular profiling for cancer, working to shape the future of clinical care and research. We collaborate with a broad range of partners across the cancer community and strive to set the standard for quality, scientific excellence, and regulatory leadership. Our deep understanding of cancer biology helps physicians make informed treatment decisions for their patients and empowers researchers to develop new medicines. Every day, we are driven to help our partners find answers and take action, enabling more people around the world to benefit from precision cancer care. For more information, please visit us on www.FoundationMedicine.com and follow us on Twitter and LinkedIn.

About FoundationOne®CDx

FoundationOne CDx is a next-generation sequencing based in vitro diagnostic device for detection of substitutions, insertion and deletion alterations (indels), and copy number alterations (CNAs) in 324 genes and select gene rearrangements, as well as genomic signatures including microsatellite instability (MSI) and tumor mutational burden (TMB) using DNA isolated from formalin-fixed, paraffin-embedded (FFPE) tumor tissue specimens. FoundationOne CDx is for prescription use only and is intended as a companion diagnostic to identify patients who may benefit from treatment with certain targeted therapies in accordance with their approved therapeutic product labeling. Additionally, FoundationOne CDx is intended to provide tumor mutation profiling to be used by qualified health care professionals in accordance with professional guidelines in oncology for patients with solid malignant neoplasms. Use of the test does not guarantee a patient will be matched to a treatment. A negative result does not rule out the presence of an alteration. Some patients may require a biopsy. For a full list of targeted therapies for which FoundationOne CDx is indicated as a companion diagnostic, please visit www.F1CDxLabel.com.

About FoundationOne®Liquid CDx

FoundationOne Liquid CDx is a qualitative next generation sequencing based in vitro diagnostic test for prescription use only that uses targeted high throughput hybridization-based capture technology to analyze 324 genes utilizing circulating cell-free DNA (cfDNA) isolated from plasma derived from anti-coagulated peripheral whole blood of advanced cancer patients. The test is FDA-approved to report short variants in over 300 genes and is a companion diagnostic to identify patients who may benefit from treatment with specific therapies (listed in Table 1 of the Intended Use) in accordance with the approved therapeutic product labeling. Additional genomic findings may be reported and are not prescriptive or conclusive for labeled use of any specific therapeutic product. Use of the test does not guarantee a patient will be matched to a treatment. A negative result does not rule out the presence of an alteration. Patients who are negative for companion diagnostic mutations should be reflexed to tumor tissue testing and mutation status confirmed using an FDA-approved tumor tissue test, if feasible. For the complete label, including companion diagnostic indications and complete risk information, please visit www.F1LCDxLabel.com.

Foundation Medicine®, FoundationOne® and FoundationCore® are a registered trademark of Foundation Medicine, Inc.

Source: Foundation Medicine

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