Common stock offered by us:

6,000,000 shares (excluding option to purchase up to 900,000 additional shares to cover over-allotments)

Initial public offering price per share:

$18.00. This represents a price per share below the price range of $20.00 to $21.00 indicated in Amendment No. 5 to the Registration Statement filed on May 31, 2007 (“Amendment No. 5”) relating to this offering.

Net proceeds to us:

Approximately $98.1 million, or $113.2 million if the underwriters exercise their over-allotment option in full, based upon an initial public offering price of $18.00 per share, after deducting underwriting discounts and commissions and estimated offering expenses payable by us.

Use of proceeds:

The net proceeds that we will receive from this offering will be less than the estimated net proceeds set forth under the caption "Use of Proceeds" in Amendment No. 5.

We currently expect to use the net proceeds from this offering as follows:

between $80.0 and $90.0 million to fund the planned U.S. launch and commercialization of Luvox CR, including $41.0 million for development and commercial milestone payments to Solvay in connection with the acquisition of our U.S. rights to Luvox CR, between $30.0 and $40.0 million for activities related to our preparation for marketing, promotion and expansion of our specialty sales force and approximately $10.0 million for production of initial commercial quantities of Luvox CR; and

the remainder to continue to fund our Phase III pivotal clinical trials of
JZP-6.

We may also use a portion of the net proceeds to fund continued development of and feasibility activities for our portfolio of clinical and early-stage product candidates during the next 12 to 15 months, as well as working capital, capital expenditures and other general corporate purposes.

Pro forma as adjusted balance sheet data:

Based on an initial public offering price of $18.00 per share, as of March 31, 2007, on a pro forma as adjusted basis, cash and cash equivalents would have been approximately $165.8 million, working capital would have been approximately

$156.4 million, total assets would have been approximately $296.1 million and total stockholders’ equity would have been approximately $174.0 million.

Pro forma as adjusted capitalization:

Based on an initial public offering price of $18.00 per share, as of March 31, 2007, on a pro forma as adjusted basis, additional paid-in capital would have been approximately $371.2 million, total stockholders’ equity would have been approximately $174.0 million and total capitalization would have been approximately $261.3 million.

Dilution:

After giving effect to the sale of common stock offered in this offering at an initial public offering price of $18.00 per share, after deducting underwriting discounts and commissions and estimated offering expenses payable by us, our pro forma as adjusted net tangible book value as of March 31, 2007 would have been approximately $72.5 million, or approximately $2.95 per share of common stock. This represents an immediate increase in pro forma as adjusted net tangible book value of $4.33 per share to existing stockholders, and an immediate dilution of $15.05 per share to investors participating in this offering. Based on an initial public offering price of $18.00, the investors purchasing shares of common stock in this offering will have purchased approximately 24% of our outstanding common stock immediately following the completion of this offering and will have contributed approximately 29% of the total consideration paid for our common stock.

If the underwriters exercise their option in full to purchase 900,000 additional shares of common stock in this offering, the pro forma as adjusted net tangible book value per share after this offering would be $3.44 per share, the increase in the pro forma net tangible book value per share to existing stockholders would be $4.82 per share and the pro forma dilution to new investors purchasing common stock in this offering would be $14.56 per share.

Executive employment agreements:

The following table estimates the value of the executive put right provided by the executive employment agreements described in the Preliminary Prospectus, calculated assuming a price per share of $18.00, which is the initial public offering price, with respect to vested shares of common stock in the event of a termination by reason of death or disability, in each case as if the named executive officer’s employment had terminated on December 29, 2006, the last business day of our prior fiscal year. The actual amounts that would be paid out in any termination event can only be determined at the time of the termination of the named executive officer’s employment with us.

The following table estimates the value of the vesting acceleration provisions provided by the executive employment agreements described in the Preliminary

Prospectus with respect to each named executive officer in the event of a termination described in the Preliminary Prospectus, in each case as if the named executive officer’s employment had terminated on December 29, 2006, the last business day of our prior fiscal year. The actual value of vesting acceleration in any termination event can only be determined at the time of the termination of the named executive officer’s employment with us.

Outstanding equity awards at fiscal year-end:

The following table shows, for the fiscal year ended December 31, 2006, the market value of shares or units of stock that had not vested at fiscal year end for our named executive officers, calculated assuming a price per share of $18.00, which is the initial public offering price, multiplied by the number of unvested shares.

Value of stock vested:

The following table shows the value realized on stock vested during the year ended December 31, 2006 for our named executive officers, calculated assuming a price per share of $18.00, which is the initial public offering price, multiplied by the number of shares vested.