1. Title of Derivative Security (Instr. 4) |
2. Date Exercisable and Expiration Date (Month/Day/Year) |
3. Title and Amount of Securities Underlying Derivative Security (Instr. 4) |
4. Conversion or Exercise Price of Derivative Security |
5. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 5) |
6. Nature of Indirect Beneficial Ownership (Instr. 5) |
Date Exercisable |
Expiration Date |
Title |
Amount or Number of Shares |
Series B Preferred Shares
|
Â
(1)
|
Â
(2)
|
Common Shares
|
967
(3)
|
$
0
|
I
|
See Footnote
(4)
|
Series E Preferred Shares
|
Â
(5)
|
Â
(2)
|
Common Shares
|
1,038,964
(3)
|
$
0
|
I
|
See Footnote
(6)
|
Stock Option (Right to Buy)
|
Â
(7)
|
06/29/2016 |
Common Shares
|
4,115
(3)
|
$
3.35
(8)
|
D
|
Â
|
Stock Option (Right to Buy)
|
Â
(9)
|
12/31/2016 |
Common Shares
|
1,028
(3)
|
$
3.21
(8)
|
D
|
Â
|
Stock Option (Right to Buy)
|
Â
(10)
|
12/31/2017 |
Common Shares
|
1,028
(3)
|
$
3.77
(8)
|
D
|
Â
|
Stock Option (Right to Buy)
|
Â
(10)
|
12/31/2018 |
Common Shares
|
1,028
(3)
|
$
3.07
(8)
|
D
|
Â
|
Stock Option (Right to Buy)
|
Â
(11)
|
12/31/2021 |
Common Shares
|
1,028
(3)
|
$
3.67
(8)
|
D
|
Â
|
Stock Option (Right to Buy)
|
Â
(12)
|
12/31/2022 |
Common Shares
|
1,028
(3)
|
$
2.68
(13)
|
D
|
Â
|
Stock Option (Right to Buy)
|
Â
(14)
|
01/13/2024 |
Common Shares
|
1,028
(3)
|
$
9.85
(15)
|
D
|
Â
|
* |
If the form is filed by more than one reporting person, see Instruction 5(b)(v). |
** |
Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a). |
(1) |
Reflects the automatic conversion of each share of Series B Preferred Shares into one share of Common Shares to occur upon the closing of the Issuer's initial public offering. |
(2) |
Each share has no expiration date. |
(3) |
Reflects a 1-for-4.86 reverse stock split of the Issuer's outstanding shares effected October 1, 2014 (the "Reverse Stock Split"). |
(4) |
These shares are held by the Stein Family LLC, for which the Reporting Person serves as the managing member. |
(5) |
Reflects the automatic conversion of each share of Series E Preferred Shares into 1.2 shares of Common Shares to occur upon the closing of the Issuer's initial public offering. |
(6) |
These shares are held by Lipoterx, Ltd. ("Lipoterx"). Lipoterx Holdings, LLC, the general partner of Lipoterx, has sole voting and investment power with respect to the shares held by Lipoterx. The Reporting Person, the managing partner of Lipoterx Holdings, LLC has sole voting and investment power with respect to the shares held by Lipoterx. |
(7) |
The shares subject to the option fully vested on June 30, 2008. |
(8) |
The exercise price was converted from $3.74 CAD using the closing rate of exchange of the Bank of Canada on the date of grant, after giving effect to the Reverse Stock Split. The actual exercise price is the Canadian dollar amount regardless of the exchange rate on the date of exercise. |
(9) |
The shares subject to the option fully vested on January 1, 2010. |
(10) |
The shares subject to the option fully vested on January 1, 2011. |
(11) |
1/3 of the shares subject to the Option vested on January 1, 2013 (the "2012 Vesting Commencement Date") and thereafter the remaining 2/3 of the shares subject to the Option vest each monthly anniversary of the 2012 Vesting Commencement Date over the following 2 years. |
(12) |
1/3 of the shares subject to the Option vested on January 1, 2014 (the "2013 Vesting Commencement Date") and thereafter the remaining 2/3 of the shares subject to the Option vest each monthly anniversary of the 2013 Vesting Commencement Date over the following 2 years. |
(13) |
The exercise price was converted from $2.67 CAD using the closing rate of exchange of the Bank of Canada on the date of grant, after giving effect to the Reverse Stock Split. The actual exercise price is the Canadian dollar amount regardless of the exchange rate on the date of exercise. |
(14) |
1/3 of the shares subject to the Option vest on January 1, 2015 (the "2014 Vesting Commencement Date") and thereafter the remaining 2/3 of the shares subject to the Option vest each monthly anniversary of the 2014 Vesting Commencement Date over the following 2 years. |
(15) |
The exercise price was converted from $10.78 CAD using the closing rate of exchange of the Bank of Canada on the date of grant, after giving effect to the Reverse Stock Split. The actual exercise price is the Canadian dollar amount regardless of the exchange rate on the date of exercise. |