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                            SCHEDULE 14A INFORMATION

PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934
                                (AMENDMENT NO. )

Filed by the Registrant [X]

Filed by a Party other than the Registrant [ ]

Check the appropriate box:

[ ] Preliminary Proxy Statement

[ ] Confidential, for Use of the Commission Only (as permitted by Rule
14a-6(e)(2))

[X] Definitive Proxy Statement

[ ] Definitive Additional Materials

[ ] Soliciting Material Pursuant to Section 240.14a-11(c) or Section  240.14a-12

                                  ZONAGEN, INC.
                ------------------------------------------------
                (NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER)

     -----------------------------------------------------------------------
     (NAME OF PERSON(S) FILING PROXY STATEMENT IF OTHER THAN THE REGISTRANT)

Payment of Filing Fee (Check the appropriate box):

[X] No fee required.

[ ] Fee computed on table below per Exchange Act Rules 14a-6(i)(4) and 0-11.

       1)     Title of each class of securities to which transaction applies:

              ------------------------------------------------------------------

       2)     Aggregate number of securities to which transaction applies:

              ------------------------------------------------------------------

       3)     Per unit price or other underlying value of transaction computed
              pursuant to Exchange Act Rule 0-11 (Set forth the amount on which
              the filing fee is calculated and state how it was determined):

              ------------------------------------------------------------------

       4)     Proposed maximum aggregate value of transaction:

              ------------------------------------------------------------------

       5)     Total fee paid:

              ------------------------------------------------------------------

[ ] Fee paid previously with preliminary materials.

[ ] Check box if any part of the fee is offset as provided by Exchange Act Rule
0-11(a)(2) and identify the filing for which the offsetting fee was paid
previously. Identify the previous filing by registration statement number, or
the Form or Schedule and the date of its filing.

       1)     Amount Previously Paid:

       2)     Form, Schedule or Registration Statement No.:

       3)     Filing Party:

       4)     Date Filed:



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                                  ZONAGEN, INC.
                        2408 TIMBERLOCH PLACE, SUITE B-4
                           THE WOODLANDS, TEXAS 77380



                                                      May 31, 2001


TO OUR STOCKHOLDERS:

       You are cordially invited to attend the 2001 Annual Meeting of
Stockholders of Zonagen, Inc. to be held on Tuesday, July 10, 2001, at 11:00
a.m., Central Daylight Time, at the Wyndham Greenspoint Hotel, 12400 Greenspoint
Drive, Houston, Texas. A Notice of the Annual Meeting, Proxy Statement and form
of proxy are enclosed with this letter.

       We encourage you to read the Notice of the Annual Meeting and Proxy
Statement so that you may be informed about the business to come before the
meeting. Your participation in the Company's business is important, regardless
of the number of shares that you hold. To ensure your representation at the
meeting, please promptly sign and return the accompanying proxy card in the
postage-paid envelope.

        We look forward to seeing you on July 10, 2001.


                                        Sincerely,

                                        /s/ Joseph S. Podolski

                                        Joseph S. Podolski
                                        President and Chief Executive Officer



   3

                           NOTICE OF ANNUAL MEETING OF
                                  STOCKHOLDERS
                            TO BE HELD JULY 10, 2001


To the Stockholders of Zonagen, Inc.:

         The Annual Meeting of Stockholders (the "Annual Meeting") of Zonagen,
Inc. (the "Company") will be held on Tuesday, July 10, 2001, at 11:00 a.m.,
Central Daylight Time, at the Wyndham Greenspoint Hotel, 12400 Greenspoint
Drive, Houston, Texas, for the following purposes:

                  1.       To elect a board of five directors of the Company,
                           each to serve until the Company's next Annual Meeting
                           of Stockholders or until their respective successors
                           have been duly elected and qualified;

                  2.       To ratify and approve the appointment of Arthur
                           Andersen LLP as the Company's independent public
                           accountants for its fiscal year ending December 31,
                           2001; and

                  3.       To act on such other business as may properly come
                           before the Annual Meeting or any adjournments
                           thereof.

         Only stockholders of record at the close of business on May 25, 2001
will be entitled to notice of and to vote at the Annual Meeting.

         It is important that your shares be represented at the Annual Meeting
regardless of whether you plan to attend. THEREFORE, PLEASE MARK, SIGN AND DATE
THE ENCLOSED PROXY AND RETURN IT IN THE ACCOMPANYING POSTPAID ENVELOPE AS
PROMPTLY AS POSSIBLE. If you are present at the Annual Meeting, and wish to do
so, you may revoke the proxy and vote in person.

                                        By Order of the Board of Directors,

                                        /s/ Louis Ploth

                                        Louis Ploth
                                        Secretary

The Woodlands, Texas
May 31, 2001



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                                  ZONAGEN, INC.
                        2408 TIMBERLOCH PLACE, SUITE B-4
                           THE WOODLANDS, TEXAS 77380

                                   ----------

                                 PROXY STATEMENT
                                       FOR
                         ANNUAL MEETING OF STOCKHOLDERS


                            TO BE HELD JULY 10, 2001



                    SOLICITATION AND REVOCABILITY OF PROXIES

         The accompanying Proxy is solicited by the Board of Directors of
Zonagen, Inc. (the "Company"), to be voted at the Annual Meeting of Stockholders
of the Company to be held on Tuesday, July 10, 2001 (the "Annual Meeting"), at
11:00 a.m., Central Daylight Time, at the Wyndham Greenspoint Hotel, 12400
Greenspoint Drive, Houston, Texas, for the purposes set forth in the
accompanying Notice of Annual Meeting of Stockholders, and at any adjournment(s)
of the Annual Meeting. If the accompanying Proxy is properly executed and
returned, the shares it represents will be voted at the Annual Meeting in
accordance with the directions noted thereon or, if no direction is indicated,
it will be voted in favor of the proposals described in this Proxy Statement. In
addition, the Proxy confers discretionary authority to the persons named in the
Proxy authorizing those persons to vote, in their discretion, on any other
matters properly presented at the Annual Meeting. The Board of Directors is not
currently aware of any such other matters.

         Each stockholder of the Company has the unconditional right to revoke
his Proxy at any time prior to its exercise, either in person at the Annual
Meeting or by written notice to the Company addressed to Secretary, Zonagen,
Inc., 2408 Timberloch Place, Suite B-4, The Woodlands, Texas 77380. No
revocation by written notice will be effective unless such notice has been
received by the Secretary of the Company prior to the day of the Annual Meeting
or by the inspector of election at the Annual Meeting.

         The principal executive offices of the Company are located at 2408
Timberloch Place, Suite B-4, The Woodlands, Texas 77380. This Proxy Statement
and the accompanying Notice of Annual Meeting of Stockholders and Proxy are
being mailed to the Company's stockholders on or about May 31, 2001.

         In addition to the solicitation of proxies by use of this Proxy
Statement, directors, officers and employees of the Company may solicit the
return of proxies by mail, personal interview, telephone or the Internet.
Officers and employees of the Company will not receive additional compensation
for their solicitation efforts, but they will be reimbursed for any
out-of-pocket expenses incurred. Brokerage houses and other custodians, nominees
and fiduciaries will be requested, in connection with the stock registered in
their names, to forward solicitation materials to the beneficial owners of such
stock.

         ALL COSTS OF PREPARING, PRINTING, ASSEMBLING AND MAILING THE NOTICE OF
ANNUAL MEETING OF STOCKHOLDERS, THIS PROXY STATEMENT, THE ENCLOSED FORM OF PROXY
AND ANY ADDITIONAL MATERIALS, AS WELL AS THE COST OF FORWARDING SOLICITATION
MATERIALS TO THE BENEFICIAL OWNERS OF STOCK AND ALL OTHER COSTS OF SOLICITATION,
WILL BE BORNE BY THE COMPANY.


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                             PURPOSES OF THE MEETING

         At the Annual Meeting, the Company's stockholders will be asked to
consider and act on the following matters:

                  1.       The election of a board of five directors of the
                           Company, each to serve until the Company's next
                           Annual Meeting of Stockholders or until their
                           respective successors have been duly elected and
                           qualified;

                  2.       A proposal to ratify and approve the appointment of
                           Arthur Andersen LLP as the Company's independent
                           public accountants for its fiscal year ending
                           December 31, 2001; and

                  3.       Such other business as may properly come before the
                           Annual Meeting or any adjournments thereof.

                                QUORUM AND VOTING

         The close of business on May 25, 2001 has been fixed as the record date
(the "Record Date") for the determination of stockholders entitled to vote at
the Annual Meeting and any adjournment(s) thereof. As of the Record Date, the
Company had issued and outstanding 11,331,856 shares of the Company's common
stock, par value $.001 share (the "Common Stock").

         Each stockholder of record of Common Stock will be entitled to one vote
per share on each matter that is called to vote at the Annual Meeting. Shares of
Common Stock may not be voted cumulatively.

         The presence, either in person or by proxy, of holders of shares
representing a majority of the Common Stock entitled to be cast at the Annual
Meeting is necessary to constitute a quorum at the Annual Meeting. Abstentions
and broker non-votes are counted for purposes of determining whether a quorum is
present. A plurality vote is required for the election of directors.
Accordingly, if a quorum is present at the Annual Meeting, the five persons
receiving the greatest number of votes will be elected to serve as directors.
Withholding authority to vote for a director nominee and broker non-votes in the
election of directors will not affect the outcome of the election of directors.
All other matters to be voted on will be decided by the vote of the holders of
shares representing a majority of the votes present or represented at the Annual
Meeting and entitled to vote on such matter. On any such matter, an abstention
will have the same effect as a negative vote but, because shares held by brokers
will not be considered entitled to vote on matters as to which the brokers
withhold authority, a broker non-vote will have no effect on such vote.

         All Proxies that are properly completed, signed and returned prior to
the Annual Meeting will be voted. Any Proxy given by a stockholder may be
revoked at any time before it is exercised by the stockholder (i) filing with
the Secretary of the Company an instrument revoking it, (ii) executing and
returning a Proxy bearing a later date or (iii) attending the Annual Meeting and
expressing a desire to vote his shares of Common Stock in person. Votes will be
counted by Computershare Investor Services, LLC, the Company's transfer agent
and registrar.

                               PROPOSAL NUMBER 1:
                              ELECTION OF DIRECTORS

         The Board of Directors has nominated and urges you to vote for the
election of the five nominees identified below, who have been nominated to serve
as directors until the next Annual Meeting of Stockholders or until their
successors are duly elected and qualified. Each of the nominees listed below is
a member of the Company's present Board of Directors. Proxies solicited hereby
will be voted for all nominees unless stockholders specify otherwise in their
Proxies.

         If, at the time of or prior to the Annual Meeting, any of the nominees
should be unable or decline to serve, the discretionary authority provided in
the Proxy may be used to vote for a substitute or substitutes designated by the
Board of Directors. The Board of Directors has no reason to believe that any
substitute nominee or nominees will be required.



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NOMINEES FOR ELECTION AS DIRECTORS

         The names of the nominees for election as directors, and certain
additional information with respect to each of them, are set forth below.



                                                                                                      YEAR FIRST
                                                                                                        BECAME
             NAME                     AGE                   POSITION WITH THE COMPANY                  DIRECTOR
             ----                     ---                   -------------------------                 ----------

                                                                                             
Martin P. Sutter............           45                      Chairman of the Board                     1987
Joseph S. Podolski..........           53              President and Chief Executive Officer             1992
                                                                   and Director
Lloyd M. Bentsen, III.......           56                            Director                            2000
Steven Blasnik..............           43                            Director                            1990
Timothy McInerney...........           40                            Director                            1996


         Martin P. Sutter. Mr. Sutter, a co-founder of the Company, has served
as Chairman of the Board of Directors since December 1987. Since July 1988, Mr.
Sutter has been the Managing General Partner of The Woodlands Venture Partners,
L.P., a venture capital firm based in Montgomery, Texas, and the General Partner
of The Woodlands Venture Fund, L.P. Since June 1998, Mr. Sutter has been
managing director of Essex Woodlands Health Ventures, L.L.C. Mr. Sutter is a
director of Aronex Pharmaceuticals, Inc., a biotechnology company based in The
Woodlands, Texas and several private health-care related companies. He has a
B.S. degree from Louisiana State University and an M.B.A. from the University of
Houston.

         Joseph S. Podolski. Mr. Podolski joined the Company in 1989 as Vice
President of Operations and has served as President and Chief Executive Officer
of the Company and as a director since 1992. Prior to joining the Company, Mr.
Podolski spent twelve years in various engineering, product development and
manufacturing positions at G.D. Searle, a subsidiary of Monsanto Company. Before
joining Monsanto, Mr. Podolski held positions in manufacturing, engineering,
quality control and development of fine chemicals, antibiotics, pharmaceuticals
and hospital products with Abbott Laboratories, Dearborn Chemical Company and
Baxter Pharmaceuticals. Mr. Podolski holds a M.S. in chemical engineering from
the Illinois Institute of Technology.

         Lloyd M. Bentsen, III. Mr. Bentsen has been a Director of the Company
since June 2000. Mr. Bentsen is a general partner and co-founder of Triad
Ventures, a group of venture capital funds with over $50 million of capital that
seeks to invest in Texas-based emerging growth companies. Prior to founding his
venture capital firm in 1979, Mr. Bentsen spent ten years with Rotan Mosle,
Inc., a regional investment banking firm, as a member of the corporate finance
department. Mr. Bentsen is also on the board of directors of Stewart Information
Services Corporation, one of the largest title insurance companies in the United
States and traded on the New York Stock Exchange. Mr. Bentsen is a graduate of
Princeton University with an M.B.A. from Stanford University.

         Steven Blasnik. Mr. Blasnik has served as a Director of the Company
since April 1990. Since 1987, Mr. Blasnik has been employed by the Perot Group
and is currently President of Perot Investments, Inc., an investment firm owned
by Ross Perot. He is also a director of Perot Systems Corporation. From 1983 to
1987, Mr. Blasnik was an attorney at Hughes & Luce in Dallas, Texas. Mr. Blasnik
has a B.S.E. from Princeton University and a J.D. from Harvard Law School.

         Timothy McInerney. Mr. McInerney has served as a Director of the
Company since December 1996. Since 1992, Mr. McInerney has been a Managing
Director of Paramount Capital, Inc. where he oversees the overall distribution
of Paramount's private equity product. Prior to 1992, Mr. McInerney was a
research analyst focusing on the biotechnology industry at Ladenburg, Thalman &
Co., and he held equity sales positions at Bear, Stearns & Co. and Shearson
Lehman Brothers, Inc. Mr. McInerney also has worked in sales and marketing for
Bristol-Myers Squibb. He received his B.S. in pharmacy from St. John's
University at New York. He also completed a post-graduate residency at the New
York University Medical Center in drug information systems.



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         THE BOARD OF DIRECTORS RECOMMENDS THAT STOCKHOLDERS VOTE "FOR" THE
ELECTION OF EACH OF THE ABOVE-NAMED NOMINEES.

DIRECTORS' MEETINGS AND COMPENSATION

         The Company's operations are managed under the broad supervision of the
Board of Directors, that has ultimate responsibility for the establishment and
implementation of the Company's general operating philosophy, objectives, goals
and policies. During 2000, the Board of Directors convened on four regularly
scheduled occasions and took certain additional actions by unanimous written
consent in lieu of meetings. All directors attended at least 75% of the meetings
held by the Board and any committee of the Board on which he served during his
tenure in 2000.

         Employee directors do not receive additional compensation for service
on the Board of Directors or its committees. The Company reimburses each
non-employee director for travel expenses incurred in connection with attendance
at Board meetings. For board meetings attended in person, certain non-employee
directors receive $1,000.00 per meeting in cash, stock awards, or options.
Employee directors are eligible to participate in the Company's 1994 Employee
and Consultant Stock Option Plan and the Amended and Restated 1993 Employee and
Consultant Stock Option Plan (the "Incentive Plans"). Non-employee directors are
entitled to participate in the Company's 2000 Non-employee Directors' Stock
Option Plan (the "2000 Director Plan").

         The Board terminated the 1996 Non-employee Directors' Stock Option Plan
(although all options previously granted will remain outstanding pursuant to
their original terms) in connection with the approval of the 2000 Director Plan.

         Under the 2000 Director Plan, (i) each non-employee director who is
first elected to the Board is entitled to receive an option to purchase 40,000
shares of Common Stock on the date on which he first becomes a non-employee
director, and (ii) each non-employee director in office on the date of the
Company's annual meeting of stockholders will receive an option to purchase
5,000 shares of Common Stock effective on such date. Additionally under the 2000
Director Plan, the chairman of the board who is first elected to the Board is
entitled to receive an option to purchase 10,000 shares of Common Stock on the
date on which he first becomes chairman, and the chairman in office on the date
of the Company's annual meeting of stockholders will receive an option to
purchase 10,000 shares of Common Stock effective on such date. Each non-employee
director in office on the date of the adoption of the 2000 Director Plan was
granted an option to purchase 40,000 shares of Common Stock on such date, and
the chairman of the board in office on the date of the adoption of the 2000
Director Plan was granted an option to purchase 10,000 shares of Common Stock on
such date. In 2000, the Company granted options to acquire an aggregate of
210,000 shares of Common Stock to non-employee directors under the 2000 Director
Plan. In March 2000, the Board of Directors approved paying each non-employee
director $1,000.00 per meeting attended in person, payable in cash, stock awards
or options, at the director's discretion. During 2000, the Company paid
$2,000.00 to one director, issued stock awards totaling 2,034 shares of Common
Stock to two directors, and granted options to purchase Common Stock totaling
1,419 to one director, for the attendance of board meetings in person.

BOARD COMMITTEES

         Pursuant to delegated authority, various Board functions are discharged
by the standing committees of the Board. The Board of Directors has appointed
four principal standing committees: the Executive Committee, the Compensation
and Option Committee, the Nominating Committee and the Audit Committee. The
Board of Directors has also appointed a subcommittee of the board to manage
efforts relating to a potential strategic transaction. The subcommittee of the
board, currently comprised of Messrs. Bentsen, Chairman and Blasnik, review and
screen potential candidates for a strategic transaction, together with the Board
of Directors and management of the Corporation, and conduct regular weekly
and/or biweekly meetings with each other and Deutsche Banc Alex. Brown. The
subcommittee convened 13 times in 2000. The Executive Committee, currently
comprised of Messrs. Sutter and Podolski, is authorized to exercise, to the
extent permitted by law, the power of the full Board of Directors when a meeting
of the full Board is not practicable or necessary. The Executive Committee
convened once in 2000. The Compensation and Option Committee, currently
comprised of Messrs. Blasnik and McInerney, selects the employees to whom stock
options are to be granted, determines the terms and conditions provided for in
each option grant and reviews and recommends to the Board of Directors the
amount of compensation to be paid to officers of the Company. The Compensation
and Option



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Committee convened on four occasions in 2000 and took certain additional actions
by unanimous written consent in lieu of meetings. The Nominating Committee is
currently comprised of Messrs. Sutter and Podolski, and did not meet during
2000. The Audit Committee, currently comprised of Messrs. Bentsen, Blasnik and
McInerney, provides assistance to the Board of Directors in fulfilling its
responsibilities relating to corporate accounting and reporting practices,
recommends to the Board of Directors the engagement by the Company of its
independent public accountants, approves services performed by the Company's
independent public accountants, including fee arrangements and the range of
audit and non-audit services, maintains a direct line of communication between
the Board of Directors and the Company's independent public accountants and
performs such other functions as may be prescribed with respect to audit
committees under applicable rules, regulations and policies of The Nasdaq Stock
Market, Inc. The Audit Committee meets quarterly and convened on four occasions
in 2000.

         As required by Nasdaq Stock Market and Securities and Exchange
Commission (the "Commission") rules regarding audit committees, the Board of
Directors has reviewed the qualifications of its Audit Committee and has
determined that none of the current members of the Audit Committee have a
relationship with the Company that might interfere with the exercise of their
independence from the Company or its management.

REPORT OF THE AUDIT COMMITTEE

         The Audit Committee includes three directors who are independent, as
defined by the standards of the Nasdaq Stock Market. The Audit Committee assists
the Board in overseeing matters relating to the Company's accounting and
financial reporting practices, the adequacy of its internal controls and the
quality and integrity of its financial statements. On May 23, 2000, the Audit
Committee adopted, and the Board of Directors ratified, a new Audit Committee
Charter which is attached hereto as Appendix A.

         The Audit Committee met four times during the year ended December 31,
2000. Also, the Audit Committee Chairman, on behalf of the Audit Committee,
reviewed with management and the independent auditors the interim financial
information included in the Company's quarterly reports on Form 10-Q for the
fiscal quarters ended March 31, June 30 and September 30, 2000 prior to their
being filed with the Commission.

         The independent auditors provided the Audit Committee with a written
statement describing all the relationships between the Company and its auditors
that might bear on the auditors' independence consistent with Independence
Standards Board Standard No. 1, "Independence Discussions with Audit
Committees." The Audit Committee also discussed with the auditors any
relationships that may impact their objectivity and independence and satisfied
itself as to the auditors' independence.

         The Audit Committee discussed and reviewed with the independent
auditors all communications required by generally accepted auditing standards,
including those described in Statement of Auditing Standards No. 61, as amended,
"Communication with Audit Committees."

         With and without management present, the Audit Committee discussed and
reviewed the results of the independent auditors' examination of the Company's
December 31, 2000 financial statements. The discussion included matters related
to the conduct of the audit, such as the selection of and changes in significant
accounting policies, the methods used to account for significant or unusual
transactions, the effect of significant accounting policies in controversial or
emerging areas, the process used by management in formulating particularly
sensitive accounting estimates and the basis for the auditors' conclusions
regarding the reasonableness of those estimates, significant adjustments arising
from the audit and disagreements, if any, with management over the application
of accounting principles, the basis for management's accounting estimates and
the disclosures in the financial statements.

         The Audit Committee reviewed the Company's audited financial statements
as of and for the year ended December 31, 2000, and discussed them with
management and the independent auditors. Based on such review and discussions,
the Audit Committee recommended to the Board that the Company's audited
financial statements be included in its Annual Report on Form 10-K for the
fiscal year ended December 31, 2000 for filing with the Commission.



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   9

FEES PAID TO PRINCIPAL ACCOUNTING FIRM

         The following table sets forth the aggregate fees billed to the Company
by its principal accounting firm, Arthur Andersen LLP, for the fiscal year ended
December 31, 2000:


                                                            
         Audit Fees                                            $ 83,800
         Financial Information Systems
             Design and Implementation Fees                           0
         All Other Fees                                          22,900
                                                               --------
                  Total Fees                                   $106,700


         The Audit Committee has considered whether the provision of the
services reflected under "All Other Fees" above might affect Arthur Andersen's
independence with respect to their audit of the Company's financial statements,
and the Audit Committee believes that such services do not affect, and are
compatible with, Arthur Andersen's independence.

         This report of the Audit Committee shall not be deemed incorporated by
reference by any general statement incorporating by reference this Proxy
Statement into any filing under the Securities Act of 1933, as amended (the
"Securities Act"), or the Securities Exchange Act of 1934, as amended (the
"Exchange Act"), except to the extent that the Company specifically incorporates
this information by reference, and shall not otherwise be deemed filed under
such Acts.

                  Steven Blasnik
                  Lloyd M. Bentsen, III
                  Timothy McInerney, Chairman

                               PROPOSAL NUMBER 2:
           RATIFICATION AND APPROVAL OF INDEPENDENT PUBLIC ACCOUNTANTS

         The Board of Directors has appointed the firm of Arthur Andersen LLP as
the Company's independent public accountants to make an examination of the
accounts of the Company for the fiscal year ending December 31, 2001, subject to
ratification by the Company's stockholders. Representatives of Arthur Andersen
LLP will be present at the Annual Meeting and will have an opportunity to make a
statement, if they desire to do so. They will also be available to respond to
appropriate questions from stockholders attending the Annual Meeting.

         THE BOARD OF DIRECTORS RECOMMENDS THAT STOCKHOLDERS VOTE "FOR"
RATIFICATION AND APPROVAL OF THE APPOINTMENT OF ARTHUR ANDERSEN LLP AS THE
COMPANY'S INDEPENDENT PUBLIC ACCOUNTANTS FOR THE FISCAL YEAR ENDED DECEMBER 31,
2001, AND PROXIES EXECUTED AND RETURNED WILL BE SO VOTED UNLESS CONTRARY
INSTRUCTIONS ARE INDICATED THEREON.



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   10

    REPORT OF THE COMPENSATION AND OPTION COMMITTEE OF THE BOARD OF DIRECTORS

         The Compensation and Option Committee (the "Committee") of the Board of
Directors of the Company currently consists of Steven Blasnik and Timothy
McInerney, neither of whom is an officer or employee of the Company. The
Committee is responsible for evaluating the performance of management and
determining the compensation for executive officers of the Company and for
administering the Company's Incentive Plans under which grants may be made to
employees of the Company. The Committee has furnished the following report on
executive compensation for 2000:

         Under the supervision of the Committee, the Company has developed a
compensation policy which is designated to attract and retain key executives
responsible for the success of the Company and motivate management to enhance
long-term stockholder value. The annual compensation package for executive
officers primarily consists of (i) a cash salary which reflects the
responsibilities relating to the position and individual performance, (ii)
variable performance awards payable in cash or stock and tied to the achievement
of certain personal and corporate goals or milestones and (iii) long-term
stock-based incentive awards which strengthen the mutuality of interests between
the executive officers and the Company's stockholders.

         In determining the level and composition of compensation of each of the
Company's executive officers, the Committee takes into account various
qualitative and quantitative indicators of corporate and individual performance.
Although no specific target has been established, the Committee generally seeks
to set salaries comparable to those of peer group companies. In setting such
salaries, the Committee considers its peer group to be certain companies in the
biotechnology industries with market capitalizations similar to that of the
Company. Such competitive group does not necessarily include the companies
comprising the indexes reflected in the performance graph in this Proxy
Statement. Because the Company is still in the development stage, the use of
certain traditional performance standards (e.g., profitability and return on
equity) is not currently appropriate in evaluating the performance of the
Company's executive officers. Consequently, in evaluating the performance of
management, the Committee takes into consideration such factors as the Company's
achieving specified milestones or goals in its clinical development programs. In
addition, the Committee recognizes performance and achievements that are more
difficult to quantify, such as the successful supervision of major corporate
projects and demonstrated leadership ability.

         Base compensation is established through negotiation between the
Company and the executive officer at the time the executive is hired, and then
subsequently adjusted when such officer's base compensation is subject to review
or reconsideration. While the Company has entered into employment agreements
with certain of its executive officers, such agreements provide that base
salaries after the initial year will be determined by the Committee after
review. When establishing or reviewing base compensation levels for each
executive officer, the Committee, in accordance with its general compensation
policy, considers numerous factors, including the responsibilities relating to
the position, the qualifications of the executive and the relevant experience
the individual brings to the Company, strategic goals for which the executive
has responsibility, and compensation levels of companies at a comparable stage
of development who compete with the Company for business, scientific and
executive talents. As stated above, such comparable companies are generally
those with similar market capitalizations and are not necessarily among the
companies comprising the industry or broad market indexes reflected in the
performance graph in this Proxy Statement. No pre-determined weights are given
to any one of such factors. The base salaries for the executive officers
generally, and the Chief Executive Officer specifically, for fiscal 2000 were
comparable to the Company's peer group companies.

         In addition to each executive officer's base compensation, the
Committee may award cash bonuses and the Committee may grant awards under the
Company's Incentive Plans to chosen executive officers depending on the extent
to which certain defined personal and corporate performance goals are achieved.
Such corporate performance goals are the same as discussed above.

         All employees of the Company, including its executive officers, are
eligible to receive long-term stock-based incentive awards under the Company's
Incentive Plans as a means of providing such individuals with a continuing
proprietary interest in the Company. Such grants further the mutuality of
interest between the Company's employees and its stockholders by providing
significant incentives for such employees to achieve and maintain high levels of
performance. The Company's Incentive Plans enhance the Company's ability to
attract and retain the services of qualified individuals. Factors considered in
determining whether such awards are granted to an executive officer of the
Company include the executive's position in the Company, his or her performance
and responsibilities, the amount of



                                       7
   11

stock options, if any, currently held by the officer, the vesting schedules of
any such options and the executive officer's other compensation. While the
Committee does not adhere to any firmly established formulas or schedules for
the issuance of awards such as options or restricted stock, the Committee will
generally tailor the terms of any such grant to achieve its goal as a long-term
incentive award by providing for a vesting schedule encompassing several years
or tying the vesting dates to particular corporate or personal milestones.

         Section 162(m) of the Internal Revenue Code of 1986, as amended (the
"Code"), added by the Revenue Reconciliation Act of 1993, places a $1.0 million
cap on the deductible compensation that can be paid to certain executives of
publicly-traded corporations. Amounts that qualify as "performance based"
compensation under Section 162(m)(4)(c) of the Code are exempt from the cap and
do not count toward the $1.0 million limit. Generally, stock options will
qualify as performance based compensation. The Committee has discussed and
considered and will continue to evaluate the potential impact of Section 162(m)
on the Company in making compensation determinations, but has not established a
set policy with respect to future compensation determinations.

COMPENSATION OF CHIEF EXECUTIVE OFFICER

         The annual base salary of Joseph S. Podolski, the Company's President
and Chief Executive Officer, was increased to $235,000 for 2000. In increasing
Mr. Podolski's annual base salary for 2000, the Committee evaluated a number of
factors, including Mr. Podolski's responsibilities, his general background and
qualifications, his achievement of various corporate and personal milestones set
by the Committee from time to time, and compensation levels for executives in
Mr. Podolski's position and with his background at peer group companies. The
Committee has not attached any particular relative weighting to the foregoing
factors (or any other factors which the Committee may also consider in reaching
compensation decisions for the Company's executive officers).

         On October 18, 1999, the Company's Compensation Committee of the Board
of Directors approved and granted stay bonuses aggregating $480,000 for all
existing employees, of which Mr. Podolski's bonus was $75,000. These bonuses
were to be payable on the first working day of January 2001, for employees who
received the grants and who are still employed by the Company on December 31,
2000, subject to acceleration upon the occurrence of certain defined
circumstances. On the last working day of December 2000, the Company paid the
remaining employees their respective bonuses and related expenses which totaled
$270,000. The Committee will retain discretion to determine the amount of any
future incentive bonus awards to be paid to Mr. Podolski under its general plan
of incentive bonus awards for the Company's executive officers. The Committee
expects that it will evaluate a number of factors in reaching this decision,
including the Company's strategic goals for which Mr. Podolski has
responsibility, his other responsibilities, his initiatives and contributions to
the Company's achievement of various corporate and strategic goals and his own
achievement of certain personal milestones as determined by the Committee from
time to time.

         Mr. Podolski was not granted any options to purchase shares under the
Company's Incentive Plans during 2000. Mr. Podolski participates in the
Company's Incentive Plans on the same general terms as other participants in the
Plan, although the amount of shares underlying option grants to Mr. Podolski has
historically been larger than for other employees as a result of his position.

         In first quarter 2001, the Committee amended Mr. Podolski's employment
agreement to provide that, in the event that he terminates his employment for
Good Reason (defined as a change in duties or pay or the like) or is terminated
by the Company without Cause, within 12 months of a Change of Control, that he
will receive, in lieu of any other severance payments payable to him under such
agreement, a lump sum bonus payment of $666,045, as consideration for past
services and services rendered in connection with the change of control. Such
payment will be deposited in the Joe Podolski Rabbi Trust, and paid to him in
installments over the six years following the event.

         The foregoing report is given by the following members of the
Committee:

                           Timothy McInerney, Chairman
                                 Steven Blasnik

         The report of the Committee shall not be deemed incorporated by
reference by any general statement incorporating by reference this Proxy
Statement into any filing under the Securities Act of 1933, as amended, or under



                                       8
   12

the Exchange Act, except to the extent that the Company specifically
incorporates this information by reference, and shall not otherwise be deemed
filed under such Acts.

                             EXECUTIVE COMPENSATION

EXECUTIVE OFFICERS

         Set forth below is certain information concerning the executive
officers of the Company, including the business experience of each during the
past five years.



               NAME                   AGE                           POSITION
               ----                   ---                           --------
                                       
  Joseph S. Podolski.............     53     President, Chief Executive Officer, and Director
  Paul Lammers M.D., M.Sc........     43     Senior Vice President, Clinical and Regulatory
                                             Affairs
  Louis Ploth, Jr................     46     Chief Financial Officer, Vice President, Business
                                             Development and Secretary


         Information pertaining to Mr. Podolski, who is both a director and an
executive officer of the Company, may be found in the section entitled
"Directors".

         Paul Lammers, M.D., M.Sc. Dr. Lammers joined the Company as Senior Vice
President, Clinical and Regulatory Affairs in 1998. Previously Dr. Lammers was
with Hoechst Marion Roussel where he managed the Medical Services Group as Head
of Medical Services in International Marketing. Prior to joining Hoechst, Dr.
Lammers was employed for eight years at Organon, Inc., serving most recently as
Medical Director and Director of Medical Services. Dr. Lammers holds M.Sc. and
M.D. degrees from Catholic University, Nijmegen, The Netherlands.

         Louis Ploth, Jr. Mr. Ploth has fifteen years experience in the
biotechnology industry. Since January 2001, Mr. Ploth has served as Chief
Financial Officer, Vice President, Business Development and Secretary. He served
as Vice President, Finance from March 1999 to January 2001. He had previously
served as Chief Financial Officer and Vice President, Business Development from
1993 to 1998 and as Chief Financial Officer from 1998 to March 1999. Previously
Mr. Ploth was employed by Unisyn Technologies where he served concurrently as
Chief Financial Officer and as Vice President of Finance and Administration. Mr.
Ploth was also Corporate Controller of Synbiotics Corporation. Mr. Ploth has a
B.S. degree from Montclair State College.



                                       9
   13

COMPENSATION OF EXECUTIVE OFFICERS

Summary Compensation Table

         The following table provides certain summary information concerning
compensation paid or accrued during the last three years to the Company's
President and Chief Executive Officer and to each of the four highest paid
executive officers of the Company, determined as of the end of the last fiscal
year, whose annual compensation exceeded $100,000 (the "Named Executive
Officers"):



                                                   ANNUAL COMPENSATION                   LONG-TERM COMPENSATION
                                                                                       RESTRICTED     SECURITIES
                                                                                         STOCK        UNDERLYING     ALL OTHER
NAME AND PRINCIPAL POSITION                  YEAR       SALARY         BONUS            AWARDS($)     OPTIONS(#)   COMPENSATION(1)
---------------------------                  ----     ----------     ----------        ----------     ----------   ---------------

                                                                                                 
Joseph S. Podolski .......................   2000     $  232,500     $   75,000(3)             --             --     $    6,000(4)
     President and Chief Executive           1999     $  225,000     $   13,680(2)             --         35,000     $    6,000(4)
       Officer                               1998     $  200,000     $  136,630                --             --     $    6,000(4)

Paul Lammers .............................   2000     $  190,258     $   57,500(3)             --         20,000             --
     Senior Vice President, Clinical         1999     $  181,248             --                --         35,000             --
     and Regulatory Affairs                  1998     $  122,724             --                --         40,000     $   42,029(5)

Louis Ploth, Jr ..........................   2000     $  129,600     $   57,500(3)             --         20,000             --
     Chief Financial Officer, Vice           1999     $  121,500     $   28,500                --         30,000             --
     President, Business Development         1998     $  112,250             --                --          5,000             --
     and Secretary

F. Scott Reding ..........................   2000     $  196,875     $   57,500(3)             --          5,000             --
     Former Senior Vice President,           1999     $  145,833             --                --         75,000     $    2,906(5)
     Chief Financial Officer and             1998             --             --                --             --             --
     Secretary(6)

Michael T. Redman ........................   2000     $  151,667     $   35,000(3)             --          5,000             --
     Former Vice President, Business         1999     $  131,250             --                --         25,000     $   19,470(5)
     Development (6)                         1998     $   18,750             --                --         25,000             --


----------

(1)  During the periods indicated, perquisites for each individual named in the
     Summary Compensation Table aggregated less than 10% of the total annual
     salary and bonus reported for such individual in the Summary Compensation
     Table. Accordingly, no such amounts are included in the Summary
     Compensation Table.

(2)  Performance bonus paid in 2000 but earned in 1999.

(3)  Stay bonus granted on October 18, 1999 and paid during 2000.

(4)  Represents car allowance.

(5)  Represents relocation allowance.

(6)  Resigned on July 27, 2000 with an effective date of January 31, 2001. In
     connection with Messrs. Reding's and Redman's resignations, the Company has
     entered into a Full and Complete Settlement Agreement and Release of all
     Claims, with each, dated July 27, 2000 pursuant to which each of Messrs.
     Reding and Redman received his full salary at the time of his termination
     for the period through January 31, 2001.



                                       10
   14

     Option Grants in 2000

         The following table provides certain information with respect to
options granted to the President and Chief Executive Officer and to each of the
Named Executive Officers during the fiscal year ended December 31, 2000 under
the Company's Incentive Plans:



                                                                                                   POTENTIAL REALIZABLE VALUE AT
                                                                                                   ASSUMED ANNUAL RATES OF STOCK
                                                 INDIVIDUAL GRANTS                             PRICE APPRECIATION FOR OPTION TERM(1)
                          -------------------------------------------------------------------  -------------------------------------
                                       PERCENT OF
                           NUMBER OF     TOTAL
                          SECURITIES    OPTIONS                      MARKET
                          UNDERLYING   GRANTED TO                   PRICE ON
                           OPTIONS    EMPLOYEES IN    EXERCISE       DATE OF       EXPIRATION
        NAME              GRANTED(#)  FISCAL YEAR      PRICE          GRANT           DATE         0%          5%            10%
        ----              ----------  ------------   ----------     ----------     ----------   --------   ----------     ----------
                                                                                                  

Joseph S. Podolski .....          --         --              --             --             --         --           --             --
Paul Lammers ...........       5,000        3.7%     $     4.31     $     4.31     04/17/2010         --   $   13,562     $   34,369
Paul Lammers ...........      15,000       11.0%     $     3.47     $     3.47     09/29/2010         --   $   32,725     $   82,930
Louis Ploth, Jr ........      20,000       14.7%     $     3.47     $     3.47     09/29/2010         --   $   43,633     $  110,574
F. Scott Reding ........       5,000        3.7%     $     4.31     $     4.31     04/17/2010         --   $   13,562     $   34,369
Michael T. Redman ......       5,000        3.7%     $     4.31     $     4.31     04/17/2010         --   $   13,562     $   34,369


----------

(1)  The Securities and Exchange Commission (the "SEC") requires disclosure of
     the potential realizable value or present value of each grant. The
     disclosure assumes the options will be held for the full ten-year term
     prior to exercise. Such options may be exercised prior to the end of such
     ten-year term. The actual value, if any, an executive officer may realize
     will depend on the excess of the stock price over the exercise price on the
     date the option is exercised. There can be no assurance that the stock
     price will appreciate at the rates shown in the table.

     Option Exercises and Holdings

         The following table sets forth information concerning option exercises
and the value of unexercised options held by the President and Chief Executive
Officer and each of the Named Executive Officers of the Company named in the
Summary Compensation Table as of the end of the last fiscal year:

                       AGGREGATED OPTION EXERCISES IN 2000
                     AND OPTION VALUES AT DECEMBER 31, 2000



                                                          NUMBER OF SECURITIES          VALUE OF UNEXERCISED
                                                         UNDERLYING UNEXERCISED             IN-THE-MONEY
                                                             OPTIONS HELD AT               OPTIONS HELD AT
                             SHARES                         DECEMBER 31, 2000            DECEMBER 31, 2000(1)
                          ACQUIRED ON       VALUE       ---------------------------   ---------------------------
        NAME              EXERCISE (#)   REALIZED ($)   EXERCISABLE   UNEXERCISABLE   EXERCISABLE   UNEXERCISABLE
        ----              ------------   ------------   -----------   -------------   -----------   -------------

                                                                                  
Joseph S. Podolski ...         15,189     $   58,979        184,360         88,000     $   54,310     $       --
Paul Lammers .........             --             --         28,000         67,000     $       --     $       --
Louis Ploth, Jr ......             --             --         64,100         57,600     $       --     $       --
F. Scott Reding ......             --             --         20,000         60,000     $       --     $       --
Michael T. Redman ....             --             --         24,000         41,000     $       --     $       --


----------

(1)  Computed based on the difference between aggregate fair market value and
     aggregate exercise price. The fair market value of the Company's Common
     Stock on December 31, 2000 was $2.625, based on the closing sales price on
     the Nasdaq Stock Market on December 31, 2000.

EMPLOYMENT AGREEMENTS

         The Company has employment agreements with Messrs. Podolski, Lammers,
and Ploth which provide for current annual salaries of $235,000, $192,938, and
$140,000, respectively. The agreements provide that the Company



                                       11
   15

will pay Messrs. Podolski, Lammers, and Ploth an annual incentive bonus as may
be approved by the Board of Directors and that they are entitled to participate
in all employee benefit plans sponsored by the Company. Mr. Podolski's
employment agreement provides for a primary term expiring in January 2002, with
automatic annual renewals unless terminated by either party. If terminated for
reasons other than cause, Mr. Podolski is entitled to receive his annual base
salary and certain employment benefits for one year following termination. In
the first quarter of 2001, the Board amended Mr. Podolski's employment agreement
to provide that in the event that he terminates his employment for Good Reason
(defined as a change in duties or pay or the like) or is terminated by the
Company without Cause, within 12 months of a Change of Control, that he will
receive, in lieu of any other severance payments payable to him under such
agreement, a lump sum bonus payment of $666,045, as consideration for past
services and services rendered in connection with the change of control. Such
payment will be deposited in the Joe Podolski Rabbi Trust, and paid to him in
installments over the six years following the event. The employment agreements
for Messrs. Lammers, and Ploth expire in April 2001 and October 2001,
respectively, with automatic annual renewals unless otherwise terminated by
either party. If terminated for reasons other than cause, Messrs. Lammers, and
Ploth are entitled to salary and certain employment benefits for six months
following termination.

         In addition, the Company amended the employment agreements with Messrs.
Lammers and Ploth in 2001. The amendments provide the following additional
benefits for Messrs. Lammers and Ploth provided they remain employed by the
Company at the date of a change of control:

o    a lump sum cash bonus payable upon the earlier of (i) a change in control
     (as defined therein) or (ii) the Board's termination of further action to
     facilitate a change in control;

o    upon a change in control, all outstanding options they hold shall
     accelerate in full and shall remain exercisable for two years following the
     change in control;

o    upon a change in control, the Company shall pay each of them a lump sum
     cash payment equal to one-half of their then current annual salary and

o    for a period of six months following a change in control, the Company shall
     continue to provide their fringe benefits, such as health and dental
     insurance.

         During 2000, the Company entered into a Full and Complete Settlement
Agreement and Release of all Claims (the "Settlement Agreement") with each of
Messrs. Reding and Redman. The agreements provide:

o    a lump sum cash payment equal to one-half of each of their annual salaries
     at termination;

o    all of their outstanding options remain exercisable for two years from the
     date of termination and

o    for six months following their respective terminations, the Company
     provided them with their fringe benefits, such as health and dental
     insurance.

         Except for the remaining period of exercisability for the options
mentioned above, the Company has satisfied all of its obligations under the
Settlement Agreements with Messrs. Reding and Redman.



                                       12
   16

PERFORMANCE GRAPH

         The following performance graph compares the performance of the
Company's Common Stock to the Nasdaq Combined Composite Index and to the Nasdaq
Index of Pharmaceutical Companies. The graph covers the fiscal years ending
December 31, 1995 to December 31, 2000. The graph assumes that the value of the
investment in the Company's Common Stock and each index was $100 at December 31,
1995 and that all dividends were reinvested.

                         COMPARISON OF CUMULATIVE RETURN
                              AMONG ZONAGEN, INC.,
                        NASDAQ COMBINED MARKET INDEX AND
                      NASDAQ PHARMACEUTICAL COMPANIES INDEX


                                    [GRAPH]




                                             12/31/95      12/31/96    12/31/97    12/31/98     12/31/99    12/31/00
                                             --------      --------    --------    --------     --------    --------

                                                                                          
Zonagen, Inc.                                     100         86.21      167.24      175.86        40.23       24.14
Nasdaq Combined Market Index                      100        122.43      149.45      206.99       385.90      233.03
Nasdaq Pharmaceutical Companies Index             100        100.13      103.19      130.23       246.87      307.90


         The foregoing stock price performance comparisons shall not be deemed
incorporated by reference by any general statement incorporating by reference
this Proxy Statement into any filing under the Securities Act or Exchange Act,
except to the extent that the Company specifically incorporates this graph by
reference, and shall not otherwise be deemed filed under such Acts.



                                       13
   17

COMPENSATION AND OPTION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION

         The Compensation and Option Committee currently consists of Messrs.
Blasnik and McInerney. During fiscal 2000, no executive officer of the Company
served as (i) a member of the compensation committee (or other board committee
performing equivalent functions) of another entity, one of whose executive
officers served on the Compensation Committee of the Board of Directors, (ii) a
director of another entity, one of whose executive officers served on the
Compensation Committee of the Board of Directors of the Company or (iii) a
member of the compensation committee (or other board committee performing
equivalent functions) of another entity, one of whose executive officers served
as a director of the Company.

         SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

         The following table presents certain information regarding the
beneficial ownership of the Company's Common Stock as of March 1, 2001 by (i)
each person who is known by the Company to own beneficially more than five
percent of the outstanding shares of Common Stock, (ii) each director of the
Company, (iii) the Company's chief executive officer and each of the other Named
Executive Officers and (iv) all directors and executive officers as a group.
Except as described below, each of the persons listed in the table has sole
voting and investment power with respect to the shares listed.



                                                                       AMOUNT AND
                                                                        NATURE OF
                                                                       BENEFICIAL
                                                                      OWNERSHIP OF            PERCENTAGE
                  NAME OF BENEFICIAL OWNER                           COMMON STOCK(1)          OF CLASS(2)
                  ------------------------                           ---------------          -----------
                                                                                      
Petrus Fund, L.P.
     12377 Merit Dr., Suite 1700
     Dallas, TX  75251......................................              755,793                6.7%
Steven Blasnik..............................................              797,974(3)             7.0%
Joseph S. Podolski..........................................              222,170(4)             1.9%
Martin P. Sutter ...........................................              206,570(5)             1.8%
Timothy McInerney...........................................              107,843(6)               *
Louis Ploth.................................................               68,500(7)               *
Paul Lammers, MD............................................               36,000(8)               *
F. Scott Reding.............................................               27,132(9)               *
Michael T. Redman...........................................               24,000(10)              *
All directors and executive officers
     As a group (8 persons).................................            1,490,189(3)-(10)       12.6%



*    Does not exceed one percent.

(1)  Unless otherwise noted, the Company believes that all persons named in the
     table have sole voting and investment power with respect to all shares of
     Common Stock beneficially owned by such persons.

(2)  In accordance with the rules of the Securities and Exchange Commission,
     each beneficial owner's percentage ownership assumes the exercise or
     conversion of all options, warrants and other convertible securities held
     by such person and that are exercisable or convertible within 60 days after
     March 1, 2001.

(3)  Includes (i) 755,793 shares of Common Stock which may be deemed to be
     beneficially owned by Mr. Blasnik by virtue of his affiliation with Petrus
     Fund, L.P. and (ii) 42,181 shares of Common Stock issuable upon the
     exercise of options. Mr. Blasnik disclaims beneficial ownership of the
     shares owned by Petrus Fund, L.P.

(4)  Includes (i) 300 shares of Common Stock which are held by certain of Mr.
     Podolski's family members and (ii) 184,360 shares of Common Stock issuable
     upon the exercise of options. Mr. Podolski disclaims beneficial ownership
     of the shares owned by his family members.

(5)  Includes (i) 115,029 shares of Common Stock which may be deemed to be
     beneficially owned by Mr. Sutter by virtue of his affiliation with
     Essex/Woodlands Health Ventures, L.P., (ii) 40,000 shares of Common Stock
     issuable upon the exercise of options and (iii) 524 shares of Common Stock
     which are held by certain of Mr. Sutter's family members. Mr. Sutter
     disclaims beneficial ownership of the shares owned by Essex/Woodlands
     Health Ventures, L.P. and by his family members.

(6)  Includes (i) 51,194 shares of Common Stock issuable upon the exercise of
     warrants, (ii) 27,500 shares of Common Stock issuable upon the exercise of
     options, and (iii) 3,131 shares of Common Stock which are held by certain
     of Mr. McInerney's family members. Mr. McInerney disclaims beneficial
     ownership of the shares owned by his family members.



                                       14
   18

(7)  Includes 66,100 shares of Common Stock issuable upon the exercise of
     options.

(8)  Represents 36,000 shares of Common Stock issuable upon the exercise of
     options.

(9)  Includes (i) 100 shares of Common Stock which are held by a certain of Mr.
     Reding's family members and (ii) 20,000 shares of Common Stock issuable
     upon the exercise of options. Mr. Reding disclaims beneficial ownership of
     the shares owned by his family member.

(10) Represents 24,000 shares of Common Stock issuable upon the exercise of
     options.

                          COMPLIANCE WITH SECTION 16(a)

         Section 16(a) of the Securities Exchange Act of 1934, as amended,
requires the Company's directors and officers, and persons who own more than 10%
of the Common Stock, to file initial reports of ownership and reports of changes
in ownership (Forms 3, 4, and 5) of Common Stock with the Securities and
Exchange Commission (the "SEC"). Officers, directors and greater than 10%
stockholders are required by SEC regulation to furnish the Company with copies
of all such forms that they file.

         To the Company's knowledge, based solely on the Company's review of the
copies of such reports received by the Company and on written representations by
certain reporting persons that no reports on Form 5 were required, the Company
believes that during the fiscal year ended December 31, 2000, all Section 16(a)
filing requirements applicable to its officers, directors and 10% stockholders
were complied with in a timely manner, except for one filing on Form 3 for Lloyd
M. Bentsen, III and one filing on Form 4 for each of Martin P. Sutter and
Timothy McInerney, all of which were filed late.

                            PROPOSALS OF STOCKHOLDERS

         Any proposal of a stockholder intended to be presented at the next
annual meeting must be received at the Company's principal executive offices no
later than January 31, 2002 if the proposal is to be considered for inclusion in
the Company's Proxy Statement relating to such meeting.

                              FINANCIAL INFORMATION

         A COPY OF THE COMPANY'S ANNUAL REPORT ON FORM 10-K, INCLUDING ANY
FINANCIAL STATEMENTS AND SCHEDULES AND EXHIBITS THERETO, MAY BE OBTAINED WITHOUT
CHARGE BY WRITTEN REQUEST TO SECRETARY, ZONAGEN, INC., 2408 TIMBERLOCH PLACE,
SUITE B-4, THE WOODLANDS, TEXAS 77380.

                                        By Order of the Board of Directors

                                        /s/ Louis Ploth

                                        Louis Ploth
                                        Secretary

May 31, 2001
The Woodlands, Texas




                                       15
   19

                                                                      APPENDIX A

                                  ZONAGEN, INC.
                             AUDIT COMMITTEE CHARTER


THE AUDIT COMMITTEE IS APPOINTED BY THE BOARD TO ASSIST THE BOARD IN MONITORING
(1) THE INTEGRITY OF THE FINANCIAL STATEMENTS OF THE COMPANY, (2) THE COMPLIANCE
BY THE COMPANY WITH LEGAL AND REGULATORY REQUIREMENTS AND (3) THE INDEPENDENCE
AND PERFORMANCE OF THE COMPANY'S INTERNAL AND EXTERNAL AUDITORS.

The members of the Audit Committee shall meet the independence and experience
requirements of the Nasdaq Stock Market, Inc. The members of the Audit Committee
shall be appointed by the Board on the recommendation of the Executive
Committee.

The Audit Committee shall have the authority to retain special legal, accounting
or other consultants to advise the Committee. The Audit Committee may request
any officer or employee of the Company or the Company's outside counsel or
independent auditor to attend a meeting of the Committee or to meet with any
members of, or consultants to, the Committee.

The Audit Committee shall make regular reports to the Board.

The Audit Committee shall:

         1.       Review and reassess the adequacy of this Charter annually and
                  recommend any proposed changes to the Board for approval.

         2.       Review the annual audited financial statements with
                  management, including major issues regarding accounting and
                  auditing principles and practices as well as the adequacy of
                  internal controls that could significantly affect the
                  Company's financial statements.

         3.       Review an analysis prepared by management and the independent
                  auditor of significant financial reporting issues and
                  judgments made in connection with the preparation of the
                  Company's financial statements.

         4.       Review with management and the independent auditor the
                  Company's quarterly financial statements prior to the filing
                  of its Form 10-Q.

         5.       Meet periodically with management to review the Company's
                  major financial risk exposures and the steps management has
                  taken to monitor and control such exposures.

         6.       Review major changes to the Company's auditing and accounting
                  principles and practices as suggested by the independent
                  auditor, internal auditors or management.

         7.       Recommend to the Board the appointment of the independent
                  auditor, which firm is ultimately accountable to the Audit
                  Committee and the Board.

         8.       Approve the fees to be paid to the independent auditor.

         9.       Receive periodic reports from the independent auditor
                  regarding the auditor's independence consistent with
                  Independence Standards Board Standard 1, discuss such reports
                  with the auditor, and if so determined by the Audit Committee,
                  take or recommend that the full Board take appropriate action
                  to oversee the independence of the auditor.

         10.      Evaluate together with the Board the performance of the
                  independent auditor and, if so determined by the Audit
                  Committee, recommend that the Board replace the independent
                  auditor.

         11.      Review the appointment and replacement of the senior internal
                  auditing executive.

         12.      Review the significant reports to management prepared by the
                  internal auditing department and management's responses.

         13.      Meet with the independent auditor prior to the audit to review
                  the planning and staffing of the audit.

         14.      Obtain from the independent auditor assurance that Section 10A
                  of the Securities Exchange Act of 1934 has not been
                  implicated.

         15.      Obtain reports from management, the Company's senior internal
                  auditing executive and the



                                       A-1
   20

                  independent auditor that the Company's subsidiary/foreign
                  affiliated entities are in conformity with applicable legal
                  requirements and the Company's Code of Conduct.

         16.      Discuss with the independent auditor the matters required to
                  be discussed by Statement on Auditing Standards No. 61
                  relating to the conduct of the audit.

         17.      Review with the independent auditor any problems or
                  difficulties the auditor may have encountered and any
                  management letter provided by the auditor and the Company's
                  response to that letter. Such review should include:

                  a.       Any difficulties encountered in the course of the
                           audit work, including any restrictions on the scope
                           of activities or access to required information.

                  b.       Any changes required in the planned scope of the
                           internal audit.

                  c.       The internal audit department responsibilities,
                           budget and staffing.

         18.      Prepare the report required by the rules of the Securities and
                  Exchange Commission to be included in the Company's annual
                  proxy statement.

         19.      Advise the Board with respect to the Company's policies and
                  procedures regarding compliance with applicable laws and
                  regulations and with the Company's Code of Conduct.

         20.      Review with the Company's General Counsel legal matters that
                  may have a material impact on the financial statements, the
                  Company's compliance policies and any material reports or
                  inquiries received from regulators or governmental agencies.

         21.      Meet at least annually with the chief financial officer, the
                  senior internal auditing executive and the independent auditor
                  in separate executive sessions.

While the Audit Committee has the responsibilities and powers set forth in this
Charter, it is not the duty of the Audit Committee to plan or conduct audits or
to determine that the Company's financial statements are complete and accurate
and are in accordance with generally accepted accounting principles. This is the
responsibility of management and the independent auditor. Nor is it the duty of
the Audit Committee to conduct investigations, to resolve disagreements, if any,
between management and the independent auditor or to assure compliance with laws
and regulations and the Company's Code of Conduct.



                                       A-2

   21
                                  ZONAGEN, INC.
   PLEASE MARK VOTE IN OVAL IN THE FOLLOWING MANNER USING DARK INK ONLY. [X]

[                                                                              ]


                                                        
1. Election of Directors -                                    For   Withhold    For All
   Nominee(s):                                                All      All     Except(*)
   01 Martin P. Sutter        02 Joseph S. Podolski
   03 Lloyd M. Bentsen III    04 Steven Blasnik               [ ]      [ ]        [ ]
   05 Timothy McInerney

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(*) INSTRUCTION: To withhold authority to vote for any individual nominee,
print that nominee's name on the line provided:

2. To ratify the election of Arthur Andersen LLP as           For    Against    Abstain
   independent accountants of the Company for
   the fiscal year ended December 31, 2001.                   [ ]      [ ]        [ ]

At their discretion, the proxies are authorized to vote on such other business
as may properly come before the meeting.





                       THIS SPACE RESERVED FOR ADDRESSING
                            (key lines do not print)



                                Date:                                     , 2001
                                     -------------------------------------

Signature(s)
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Please date, sign as name appears at the left, and return promptly. If the
Shares are registered in the names of two or more persons, each should sign.
When signing as Corporate Officer, President, Executor, Administrator, Trustee
or Guardian, please give full title. Please note any changes in your address
alongside the address as it appears in the proxy.

--------------------------------------------------------------------------------
                   o       FOLD AND DETACH HERE      o

                             YOUR VOTE IS IMPORTANT!

           PLEASE VOTE, SIGN, DATE AND RETURN THIS PROXY CARD PROMPTLY
                          USING THE ENCLOSED ENVELOPE.


                                                 
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          PROOF          NO. 3                           CONTACT
                                                      SCOTT SWANEY
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          DATE 5-25-01        ORDER #   4687            REQUISITION #   5296
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          REMARKS:                      2 of 2
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                              (PLEASE CHECK CAREFULLY!)

          It is most important to you that every section of this proof be
          checked for copy, spelling, position on the form, additions and/or
          deletions. Please make your corrections anywhere necessary on this
          proof, then sign as responsible party at the bottom. Return by mail,
          messenger or fax.

                                   CHANGES IN COPY
                                   ---------------

          If alterations or changes to original copy (or repeat orders) are
          made, you will be charged at a per hour rate.

            Approved AS IS  [ ]        WITH CORRECTIONS AS SHOWN  [ ]


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                             (ALL PROOFS MUST BE SIGNED)
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